Clinical trials: Sepsis, completed
Septic Shock
Proadrenomedullin and Copeptin in Patients With Septic Shock
This study evaluates the usefulness of pro-adrenomedullin (precursor of a vasodilatory peptide involved in septic shock pathogenesis) and copeptin (a stable peptide of the arginine vasopressin precursor) to predict, at the moment…
- Trial name
- proADM (NCT03104933)
- Where
- Spain
- Volunteers
- 103 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Sepsis, Severe Sepsis
TRIAGE: TRIage of Sepsis At emerGency dEpartment
Sepsis is a serious systemic disease defined as a combination of Systemic Inflammation Response Syndrome (SIRS) plus a confirmed or suspected infection.
- Trial name
- TRIAGE (NCT02739152)
- Where
- 14 sites in Belgium, France
- Volunteers
- 602 people
- Sponsor
- BioMérieux
Bloodstream Infections, Enterobacteriaceae Infections
ANTIBIOTIC-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTIONS AND RISK FACTORS IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT
In this study, we first aimed to reveal the resistance profile of Enterobacteriales bloodstream infections at our center. We evaluated data from patients with ESBL, colistin, and carbapenem resistance and identified resistance…
- Conditions
- Bloodstream Infections, Enterobacteriaceae Infections, Intensive Care (ICU), Antibiotic Resistant Infection
- Trial name
- NCT07172932
- Where
- Turkey (Türkiye)
- Volunteers
- 314 people
- Sponsor
- Ankara City Hospital Bilkent
Glucose, High Blood, Inflammatory Response
Foodprint 1.0: Physiological Acute Responses After Consumption of Confectionary Products
The composition of a food or a meal consumed plays an important role in the rate of postprandial endocrine and metabolic response, especially if high in fats, sugars and total energy content and a reduction in its entity is…
- Conditions
- Glucose, High Blood, Inflammatory Response, Oxidative Stress, Endotoxemia
- Trial name
- FP1 (NCT03972878)
- Testing
- control snack, control cream, cream version 1
- Where
- Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Parma
Hepatitis B Infection, Chronic Infection
Nucleoside Analogue Prevent Vertical Transmission of Hepatitis B Virus
To explore the antiviral effect of nucleoside analogue in late pregnancy and the safety of the antiviral drug to fetus.To establish the best therapy strategy to pregnant women with high level of HBV DNA.
- Conditions
- Hepatitis B Infection, Chronic Infection, Viremia
- Trial name
- NCT01788371
- Testing
- Telbivudine, Lamivudine
- Volunteers
- 700 people
- Sponsor
- Hua Zhang
Systemic Inflammatory Process, Anemia
Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia
Iron affects immunity. However, the exact effect of iron on the innate immune response is not known. Animal data suggest that iron administration induced oxidative stress which enhances the innate immune response, whereas iron…
- Trial name
- NCT01349699
- Testing
- iron sucrose, Deferasirox, endotoxin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients.
This study will directly compare meropenem with standard first line antibiotic therapies in subjects entering an ICU with secondary nosocomial sepsis, or who contract sepsis while resident in an ICU.
- Trial name
- NCT00318552
- Testing
- Meropenem
- Where
- 12 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Pfizer
Internal Jugular Vein, Inferior Vena Cava
Internal Jugular Vein and Inferior Vena Cava Collapsibility Indices as a Guidance of Fluid Responsiveness in Septic Shock Cancer Patients
This study aimed to compare between internal jugular vein and inferior vena cava collapsibility indices as a guidance of fluid responsiveness in septic shock cancer patients.
- Conditions
- Internal Jugular Vein, Inferior Vena Cava, Collapsibility Indices, Fluid Responsiveness
- Trial name
- NCT07879287
- Testing
- Ultrasonographic assessment of internal jugular vein (IJV) collapsibility, Ultrasonographic assessment of inferior vena cava (IVC) collapsibility
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Malaria,Falciparum, Malaria
Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
This is an open-label, adaptive study that will utilise the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile of pyronaridine.
- Conditions
- Malaria,Falciparum, Malaria, Malaria Recrudescence, Parasitemia
- Trial name
- NCT05287893
- Testing
- Pyronaridine, P. falciparum IBSM infection
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Sepsis .
Serum STREM and MNDA Mointoring in ICU
A total of 120 patients will be included in the study. Sixty patients are critically ill with evidence of sepsis during ICU stay (sepsis group) and sixty patients are critically ill without evidence of infectious organism (SIRS…
- Trial name
- NCT02120521
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Late Onset Neonatal Sepsis, Necrotizing Enterocolitis
Effects of Oral Probiotic Supplementation on the Clinical Status of Very-low-birth-weight Preterm Neonates.
The purpose of this study was to evaluate the safety of a probiotic foodstuff and its influence on emergence and development of natural intestinal flora and the clinical status of premature very low birth weight neonates.
- Conditions
- Late Onset Neonatal Sepsis, Necrotizing Enterocolitis, Infant, Very Low Birth Weight
- Trial name
- NCT02073214
- Testing
- Probiotic
- Volunteers
- 182 people
- Sponsor
- IBSS Biomed S.A.
Septic Shock
Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients
1. Assess the impact of midodrine administration on weaning of IV vasopressors 2. Assess the cost effectiveness of using midodrine in critically ill patients
- Trial name
- NCT03911817
- Testing
- Midodrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Sepsis, ARDS (Acute Respiratory Distress Syndrome)
Research on Risk Assessment and Early Warning Models for Adverse Clinical Outcomes in Critically Ill Patients
This is a medical research study that uses information from past patient hospital records. It focuses on three serious conditions that often affect critically ill patients: sepsis (a life-threatening body-wide infection), ARDS (a…
- Conditions
- Sepsis, ARDS (Acute Respiratory Distress Syndrome), AKI - Acute Kidney Injury
- Trial name
- NCT07317817
- Testing
- No intervention (Observational study)
- Where
- China
- Volunteers
- 55,940 people
- Sponsor
- Chongqing Medical University
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
IMproved PREdiction of Severe Sepsis in the Emergency Department
The purposes of this study is to determine whether Heparin Binding Protein (HBP) can be used as a marker of severe sepsis (including septic shock) in patients presenting to the emergency department with suspected infection.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- IMPRESSED (NCT01392508)
- Where
- 5 sites in United States, Sweden
- Volunteers
- 759 people
- Sponsor
- Axis Shield Diagnostics Ltd
Sepsis, Infections
TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections
A pre/post interventional use trial, with ED patients who are initially triaged to locations other than a dedicated patient room in the main ED (e.g., waiting room, hallway bed, and/or the staging area/fast track area) with…
- Conditions
- Sepsis, Infections, Tachycardia, Fever
- Trial name
- TIMED (NCT06637904)
- Testing
- TriVerity Test
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Inflammatix
Sepsis Syndrome
Diagnostic Accuracy in Sepsis
The sepsis syndrome has recently been more stringently defined as "a life-threatening organ dysfunction caused by a dysregulated host response to infection".
- Trial name
- NCT03956043
- Where
- Norway
- Volunteers
- 1,989 people
- Sponsor
- Oslo University Hospital
Endotoxemia
Blockade of Vascular Potassium Channels During Human Endotoxemia
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine.
- Trial name
- NCT00185003
- Testing
- endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
Ethnic Differences in the Inflammatory Response in Systemic Inflammation
The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.
- Trial name
- NCT00284869
- Testing
- LPS
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sepsis, Septic Shock
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
Sepsis and septic shock patients are considered to have a high risk of complications and death. Appropriate antimicrobial therapy plays an important role in determining outcomes in septic patients.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Carbapenem
- Trial name
- NCT03344627
- Testing
- Meropenem standard dose, Meropenem high dose
- Where
- Thailand
- Volunteers
- 76 people
- Sponsor
- Mahidol University
All Conditions Causing Sepsis, Pneumonia - Bacterial
Comparison Between the Progostic Value of the Procalcitonin and the Platelet/Total Leukocytic Count Ratio in Sepsis
What is already known on this subject? AND What does this study add? Sepsis is a complicated condition caused by a malfunction of the host's immune response to infection, which results in an uncontrollable inflammatory response…
- Conditions
- All Conditions Causing Sepsis, Pneumonia - Bacterial, Urinary Tract Infection Bacterial
- Trial name
- NCT06991686
- Testing
- Blood samples, blood sample
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
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