Clinical trials: Sepsis, completed
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Sepsis, Septic Shock
Epidemiology of Sepsis in Turkish ICUs.
The prevalence and mortality of sepsis in Turkey is not know at large. Turkish Society of Intensive Care Medicine, Sepsis Study Group conducted a multi-centre,point prevalence survey to determine the prevalence, causative…
- Conditions
- Sepsis, Septic Shock, Severe Sepsis
- Trial name
- NCT03249246
- Testing
- No intervention
- Volunteers
- 1,499 people
- Sponsor
- Nur Baykara
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock
Septicemia
Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device
This is a matched, open label study to evaluate the Initial Specimen Diversion Device (ISDD) in reducing the contamination rate in blood culture analysis.
- Trial name
- NCT02102087
- Testing
- Initial Specimen Diversion Device (ISDD), Lab standard practice (LSP)
- Where
- United States
- Volunteers
- 971 people
- Sponsor
- Magnolia Medical Technologies, Inc.
Sepsis, Shock, Septic
Medical Education for Sepsis Source Control and Antibiotics
Patients with severe sepsis or septic shock suffer from life-threatening infections. Fast and adequate therapy with antibiotics is crucial for survival.
- Trial name
- MEDUSA (NCT01187134)
- Testing
- Change Management
- Where
- 42 sites in Germany
- Volunteers
- 4,138 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Severe Sepsis
End-of-life Decision-making in Patients With Sepsis-related Organ Failure
The care of patients with sepsis-related organ failure on the intensive care unit (ICU) often includes end-of-life decision (EOL-D) and communication of such decisions to relatives.
- Trial name
- EIDECS (NCT01247792)
- Testing
- SOPs for decision-making and communication
- Where
- Germany
- Volunteers
- 174 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Sepsis
Effect of SRT2379 on Endotoxin-Induced Inflammation
SRT2379 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice.
- Trial name
- NCT01262911
- Testing
- SRT2379
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Sirtris, a GSK Company
Septic Shock, Sepsis
Examination of ADMA Serum Level and DDAH II
Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value.
- Trial name
- ADSeS (NCT01632059)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Multiple Organ Failure, Sepsis
Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients
The purpose of this study is to determine the pharmacokinetic properties of two different dosage regimens of intravenous vitamin C in patients admitted to the Intensive Care Unit with life-threatening illness.
- Conditions
- Multiple Organ Failure, Sepsis, Systemic Inflammatory Response Syndrome, Trauma
- Trial name
- NCT02455180
- Testing
- Ascorbic Acid
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Neonatal Sepsis, Neonatal Mortality
Prevention of Nosocomial Bacteremia Among Zambian Neonates
The purpose of this study is to estimate the burden of disease, identify risk factors associated with nosocomial bacteremia among neonates and assess the efficacy of low-cost measures targeted to known and suspected nosocomial…
- Trial name
- NCT02386592
- Testing
- Chlorhexidine gluconate (CHG), Hand hygiene (HH), Infection control training
- Where
- Zambia
- Volunteers
- 9,410 people
- Sponsor
- Boston University
Severe Sepsis
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
The purpose of this study is to compare eritoran tetrasodium and placebo in patients with severe sepsis and to demonstrate a reduction of mortality from all causes.
- Trial name
- NCT00334828
- Testing
- eritoran tetrasodium
- Where
- 251 sites in United States, Argentina and 22 more
- Volunteers
- 2,000 people
- Sponsor
- Eisai Inc.
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Sepsis
Effect of SRT2104 on Endotoxin-induced Inflammation
SRT2104 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice.
- Trial name
- NCT01014117
- Testing
- SRT2104
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Salmonella Infections, Infection of Bloodstream
Reservoir of Invasive Salmonellosis in Children, DRC
Bloodstream infections caused by non-typhoid Salmonella (NTS) are a major killing disease in Sub-Saharan Africa. Despite the high case fatality rate, the main reservoir -human, zoonotic or environmental- for invasive NTS rests…
- Trial name
- NCT03073707
- Testing
- Sample collection
- Where
- Democratic Republic of the Congo
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Sepsis
Prevention of Infection in Indian Neonates - Phase II Probiotics Study
India, with one of the world's largest populations, continues to struggle with extremely high infant and neonatal mortality rates.
- Trial name
- NCT00518596
- Testing
- Probiotic supplementation (Lactobacillus plantarum)
- Where
- 3 sites in India
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sepsis
Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation
SRT2379 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice.
- Trial name
- NCT01416376
- Testing
- SRT2379
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sirtris, a GSK Company
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Septic Shock
Statin Therapy in the Treatment of Sepsis
Simvastatin will attenutat IL-6 levels and lead to a more rapid shock reversal than placebo
- Trial name
- NCT00676897
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Beth Israel Deaconess Medical Center
Newborn; Infection, Newborn Sepsis
New Protocol for Febrile Neonate Management
The objective of present study was to evaluate clinical and laboratory characteristics of febrile neonate and describe the incidence of SBI in febrile neonates.
- Trial name
- NCT03183531
- Testing
- C reactive protein
- Where
- Turkey (Türkiye)
- Volunteers
- 328 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Toxic-Shock Syndrome, Sepsis
Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- NCT02971670
- Testing
- rTSST-1 Variant Candidate Vaccine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH