Clinical trials: Sepsis, completed
Septic Shock, Volume Status
Thermodilution - Controlled Management of Volume Therapy in Septic Shock
Septic shock and multi-organ failure are among the most frequent causes of death in the ICU. Patients with septic shock require early implementation of hemodynamic therapy to keep the duration of shock state and with it…
- Trial name
- THEMIS (NCT01263977)
- Testing
- Picco- thermodilution catheter
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Claudia Spies
Severe Sepsis, Septic Shock
Procalcitonin Monitoring Sepsis Study
The purpose of this study is to investigate the relationship between a procalcitonin decrease over 72 hours and outcome in patients who have severe sepsis or septic shock.
- Trial name
- MOSES (NCT01523717)
- Where
- 13 sites in United States
- Volunteers
- 858 people
- Sponsor
- Brahms AG
Sepsis
TREM-1 Gene Polymorphisms
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the…
- Trial name
- NCT01490424
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Sepsis, Need of Cardiac Surgery
International Registry on the Use of the CytoSorb Adsorber
Registry on the use of the CytoSorb® adsorber in ICU patients.
- Trial name
- CytoSorb (NCT02312024)
- Testing
- Use of CytoSorb adsorber
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,434 people
- Sponsor
- Jena University Hospital
Bloodstream Infections, Short Bowel Syndrome
Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
The purpose of this research study is to evaluate the effects (good and bad) of supplementation with Glutamine to that of a placebo (L-alanine), on your child and their Short Bowel Syndrome.
- Conditions
- Bloodstream Infections, Short Bowel Syndrome, Development, Nutrition
- Trial name
- NCT01576003
- Testing
- Glutamine, L-alanine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Septic Shock
Methylene Blue for the Treatment of Septic Shock
The purpose of this study is to evaluate the efficacy and safety of methylene blue among adult patients with septic shock.
- Trial name
- NCT06532240
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Northern Jiangsu People's Hospital
Pleural Empyema, Tuberculosis (TB)
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion.
- Conditions
- Pleural Empyema, Tuberculosis (TB), Bacterial Sepsis
- Trial name
- NCT07167823
- Testing
- Decortication
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- University of Health Sciences Lahore
Device Related Sepsis
Novel Device for Rapid Fluid Administration
The aim of the study is to determine if a new device is more effective in fluid administration than devices currently used when resuscitating pediatric patients in septic shock.
- Trial name
- NCT03074682
- Testing
- Lifeflow, Push/Pull, Pressure Bag
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Septic Shock
Evaluation of the Role of Hydrocortisone Either Alone or Combined With Fludrocortisone in the Outcome of Septic Shock in Adults
During Infection, oflfending microbes interact with the host immune system producing a downstream inflammatory cascade involving cytokines and other mediators, which in turn triggers a systemic response.
- Trial name
- NCT04492280
- Testing
- Hydrocortisone
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Cytokine Release Syndrome, Sepsis
Cytokine Removal With CVVHD Compared to CVVH
Septic patients with acute kidney injury (SA-AKI) requiring continuous renal replacement therapies (CRRT) present high mortality due to systemic inflammatory response, cytokine liberation, and finally multiorgan dysfunction.
- Conditions
- Cytokine Release Syndrome, Sepsis, AKI
- Trial name
- NCT04048525
- Testing
- CVVHD, CVVH
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari de Bellvitge
Sepsis, Hip Fractures
The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery
The worldwide occurrence of hip fracture is high with an annual incidence of approximately 100 per 100.000 people. Mortality for patients undergoing hip fracture surgery is high with a 30-day mortality rate varying between 4.5…
- Trial name
- NCT03201679
- Testing
- Repair of hip fracture
- Volunteers
- 1,967 people
- Sponsor
- Bispebjerg Hospital
Sepsis, Acute Kidney Injury Due to Sepsis
Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury
In our study, 17 septic, 43 sepsis-related acute kidney injury and 24 control patients were enrolled. Blood and urine samples were collected at the intensive care unit from acutely diagnosed septic and sepsis-related acute kidney…
- Trial name
- NCT04968262
- Testing
- Sepsis therapy, Sepsis-related acute kidney injury therapy
- Where
- Hungary
- Volunteers
- 84 people
- Sponsor
- University of Pecs
Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome
Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes
The purpose of this study is to examine whether the value of vaginal fluid cytokine levels as well as computerized fetal ECG analysis are suitable clinical parameters to detect an imminent intra-amniotic inflammation with a high…
- Conditions
- Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome, Early Onset Neonatal Sepsis, Infection of Amniotic Cavity
- Trial name
- MuMFI-PPROM (NCT02702297)
- Testing
- single arm
- Where
- 4 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Cancer, Heart Failure
Study to Determine Therapeutic Massage Dosing to Improve Quality of Life in Hospitalized Patients Receiving Palliative Care
Therapeutic massage is the most common non-traditional treatment option offered to improve quality of life, provide comfort and decrease pain in hospice and palliative care settings outside the hospital.
- Conditions
- Cancer, Heart Failure, COPD, Sepsis
- Trial name
- NCT04916223
- Testing
- Therapeutic massage
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Medstar Health Research Institute
Acute Kidney Injury Due to Sepsis
Plasma Endostatin Predicts Outcome of Septic AKI
Introduction: Acute kidney injury (AKI) occurs up to 50% of patients admitted to intensive care unit. Plasma Endostatin, released from basement membrane of Bowman's capsule, rises early during AKI.
- Trial name
- NCT04633746
- Testing
- measuring plasma Endostatin level
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sepsis-associated Encephalopathy
Optic Nerve Sheath Diameter / Eyeball Transverse Diameter Ratio and Prognosis of Sepsis Associated Encephalopathy
Sepsis is associated with a mortality rate of 20-25%, with significant increase in case of associated comorbidities or shock. SAE is one of the most common forms of encephalopathy encountered in critically ill patients, with…
- Trial name
- NCT05918705
- Testing
- Ultrasound optic nerve sheath diameter / eyeball transverse diameter ratio
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Zagazig University
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Critically Ill Children, Sepsis
Influencing Factors of Vancomycin Trough Level in Critically Ill Children With Sepsis
The aim of the work will be to measure the vancomycin trough concentration in critically ill children with sepsis in pediatric intensive care unit and its influencing factors.
- Trial name
- NCT06661772
- Testing
- Vancomycin trough concentration method
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Benha University
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