Clinical trials: Sepsis Bacteremia
Respiratory Infections in Old Age, Bacteremia
Infectious Diseases in Aged Population
The increasing number of persons >65 years of age form a special population at risk for nosocomial and other health care-associated infections.
- Trial name
- AEQUI (NCT04825132)
- Testing
- Geriatric assessment tools
- Where
- 22 sites in France, Italy and 1 more
- Volunteers
- 521 people
- Sponsor
- University Hospital, Grenoble
Sepsis, Bacteremia
Clinical Evaluation of Novel Biomarkers in Patients With Septicemia
The protein ST2 is a member of the interleukin-1 receptor family. Blood concentrations of the soluble isoform of ST2 (sST2) are increased in inflammatory and heart diseases and are considered a prognostic marker in both.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NOBIS (NCT01359891)
- Where
- Austria
- Volunteers
- 750 people
- Sponsor
- Medical University of Graz
Bacteremia, Tooth Extraction Status Nos
Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols
The first time the American Heart Association (AHA) suggested that disinfection of the gingival sulcus be performed as a complement to antibiotic prophylaxis in patients considered to be at risk of Infective endocarditis (IE) was…
- Trial name
- NCT02150031
- Testing
- 0.2% Chlorhexidine, 1% Chlorhexidine, Blood extraction
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Sepsis, Procalcitonin
Predictive Value of Procalcitonin for Bacteremia in the ICU
Association between plasma procalcitonin levels and positive blood cultures in critical illness patients in the ICU.
- Trial name
- NCT03497741
- Testing
- procalcitonin measurement
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Rijnstate Hospital
Klebsiella Pneumonia, Bacteremia
Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremia
Carbapenem-resistant Klebsiella pneumonia (CRKp) blood stream infections (BSI) cause substantial mortality among hospitalized patients.
- Trial name
- THREAT (NCT03597841)
- Testing
- Combination therapy
- Where
- 15 sites in Turkey (Türkiye)
- Volunteers
- 278 people
- Sponsor
- Koç University
Bacteremia
Hub Cleansing to Prevent Hub Infection
Central venous catheter infections are common preventable adverse events among hospital patients. Microbes may enter catheter hubs, also known as needleless connectors, and result in downstream contamination.
- Trial name
- HUC-PHIN (NCT01563406)
- Testing
- 15 second scrub, 5 second scrub, 3.15% chlorhexidine/70% isopropyl alcohol
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Rush University Medical Center
Bacteremia
Design of a Predictive Score for Contamination of Pediatric Blood Cultures
The contamination rate for blood cultures is high in pediatrics, due to different sampling techniques and the difficulty of sampling small-weight children, thus favoring contamination of the devices at the time of sampling.
- Trial name
- HEPIC (NCT06300736)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Staph Aureus Methicillin Resistant Bacteremia
Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia
To demonstrate that the combination of daptomycin and fosfomycin is superior to daptomycin alone in the treatment of methicillin resistant Staphylococcus aureus (MRSA) bacteremia.
- Trial name
- NCT01898338
- Testing
- Fosfomycin 2gr/6h iv, Daptomycin 10mg/kg/24h iv
- Where
- 18 sites in Spain
- Volunteers
- 167 people
- Sponsor
- Miquel Pujol
Pneumonia, Meningitis
Lebanese Interhospital Pneumococcal Surveillance Program
Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection.
- Conditions
- Pneumonia, Meningitis, Sepsis, Bacteremia
- Trial name
- LIPSP (NCT00901602)
- Where
- Lebanon
- Volunteers
- 700 people
- Sponsor
- American University of Beirut Medical Center
Bile Duct Stricture, Choledocholithiasis
Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography).
The aim of this study is to prospectively evaluate the frequency of bacteremia after ERCP/cholangioscopy using the Spyglass Direct Visualization System.
- Trial name
- NCT01414400
- Testing
- Blood draw for culture
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Neonatal Sepsis
Improved Detection of Neonatal Sepsis Using a Targeted Biomarker Assay
The purpose of this study is to determine whether analysis of specific serum biomarkers will improve the diagnosis of late onset neonatal sepsis and to determine the correlation between plasma levels of specific cytokines and…
- Trial name
- NCT01120678
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Virginia
Bacteremia, Sepsis
Fast Assay for Pathogen Identification and Characterization
Sepsis is a life-threatening disease caused by a dysregulated host response to infection. This can lead to organ-dysfunction and septic shock, which is a subset of sepsis where underlying abnormalities increase mortality…
- Conditions
- Bacteremia, Sepsis, Septic Shock
- Trial name
- FAPIC (NCT03841162)
- Where
- Belgium
- Volunteers
- 1,957 people
- Sponsor
- Hasselt University
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteremia, Endocarditis
Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections
Before Daptomycin (Cubicin ®) approved by the U.S. FDA in 2003, There were large-scale clinical trials conducted that included more than 1,000 subjects and than Daptomycin got complicated skin and soft tissue infections (CSSSI)…
- Conditions
- Bacteremia, Endocarditis, Serious Gram-positive Infections
- Trial name
- NCT01301638
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital
Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria.
- Conditions
- Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection
- Trial name
- AB-care (NCT06919068)
- Testing
- Colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital