Clinical trials: Sepsis Biomarker
Neonatal Late Onset Sepsis
Validation of Biomarkers Performance to Reduce Antibiotics overUse in newBorns With Suspected Clinical Signs of InfectionS
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- RUBIS (NCT06058819)
- Testing
- Newborns suspected of Infections
- Where
- 3 sites in France
- Volunteers
- 285 people
- Sponsor
- Hospices Civils de Lyon
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Infection Systemic
Duration of Antibiotic Therapy in Critically Ill Patients: C-reactive Protein-guided Therapy Versus Best Practice
The judicious use of antibiotics is one of the main measures to limit the emergence of multidrug-resistant pathogen related to excessive antimicrobial use.
- Trial name
- NCT02987790
- Testing
- C-reactive protein
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Federal University of Minas Gerais
Sepsis, Acute Lung Injury(ALI)
Outer Membrane Vesicle and Ferroptosis-Related Signatures in Sepsis-Associated Acute Lung Injury Caused by Extra-Pulmonary Hypervirulent Klebsiella Pneumoniae
This prospective observational translational cohort study will investigate whether extra-pulmonary infection caused by hypervirulent Klebsiella pneumoniae (hvKP) is associated with an increased risk of sepsis-associated acute…
- Conditions
- Sepsis, Acute Lung Injury(ALI), Klebsiella Pneumoniae Infection, Hypervirulent Klebsiella Pneumoniae Infection
- Trial name
- OMV-FERRO-ALI (NCT07686887)
- Volunteers
- 120 people
- Sponsor
- Southeast University, China
Glucose Fluctuations in Sepsis
Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
To determine whether glucose fluctuations prior to antibiotic administration are associated with sepsis severity and poor clinical outcomes.
- Trial name
- NCT07234526
- Volunteers
- 105 people
- Sponsor
- Assiut University
Chronic Periodontitis, Bacteremia
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment.
- Trial name
- AMX-Perio (NCT03354338)
- Testing
- Amoxicillin
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Sepsis, Multiple Organ Failure
Microcirculatory Alteration and Biomarkers: New Approach for Early Assessment of Septic Multi-organ Dysfunction
The aim of this study is to investigate associations between early structural cellular injury and microvascular alteration with progression of septic organ dysfunction according to total SOFA-Score (an ICU-scoring system - the…
- Trial name
- NCT02426645
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Prof. Dr. Marc-H. Dahlke, Ph. D.
Sepsis
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
The goal of this clinical trial is to determine if vancomycin dosing in children with sepsis can be improved by using updated, personalized dosing models that account for new markers of an individual's kidney function.
- Trial name
- VAST-i (NCT07084129)
- Testing
- personalized dosing adjustment of vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
LRTI, UTI
Observational, Prospective Clinical Study to Evaluate Biomarkers as Indicators of Acute Bacterial or Viral Infections
This is an observational prospective study of an in-vitro diagnostic (IVD) assay planned to enroll 632 subjects. The study will be conducted in two stages: Stage A is aimed at identifying individual biomarkers and constructing a…
- Conditions
- LRTI, UTI, Gastroenteritis, Systemic Infections/Bacteremia/Meningitis
- Trial name
- CURIOSITY (NCT01917461)
- Where
- 2 sites in Israel
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Congenital Heart Disease, Sepsis
Pro-Calcitonin Levels Following Pediatric Cardiac Surgery
First, we, the researchers, hope to find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery.
- Conditions
- Congenital Heart Disease, Sepsis, Infection
- Trial name
- NCT00284570
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Sepsis, Septic Shock
Ionized Calcium as a Severity Marker in Septic Shock Patients
Sepsis is a serious condition where the body has an extreme, dysregulated response to an infection, often leading to life-threatening organ dysfunction.
- Conditions
- Sepsis, Septic Shock, Hypocalcemia
- Trial name
- NCT07812051
- Volunteers
- 160 people
- Sponsor
- Assiut University
Septic Shock, Acute Kidney Injury
Renin and Renal Biomarker Response to Angiotensin II
Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study.
- Trial name
- NCT04558359
- Testing
- Standard of Care, Angiotensin II
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Flannery
Intensive Care Units, Infection
Citrulline and Arginase Activity in Severe Sepsis and Septic Shock
Sepsis is an acute pathology defined as an inappropriate response of the host to infection, resulting in the onset of organ failure (Quick SOFA ≥2, or SOFA ≥2).
- Conditions
- Intensive Care Units, Infection, Biomarkers, Sepsis
- Trial name
- CARS (NCT03837730)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Infections, Sepsis
A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children
A case-control cohort study to develop and validate the performance of a whole blood gene expression test to distinguish sepsis infection from uninfected systemic inflammatory response syndrome cases in symptomatic adults and…
- Conditions
- Infections, Sepsis, SIRS
- Trial name
- NCT05142813
- Testing
- Diagnostic Test: Blood specimen collection
- Volunteers
- 1,100 people
- Sponsor
- mProbe Inc.
Sepsis, Severe Sepsis
Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)
This is a randomized controlled trial comparing standard-of-care therapy of infections in critically ill patients with a procalcitonin-guided approach evaluating efficacy (antibiotics consumption) and safety (mortality).
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- SAPS (NCT01139489)
- Testing
- procalcitonin-guidance
- Where
- Netherlands
- Volunteers
- 1,575 people
- Sponsor
- Amsterdam UMC, location VUmc
Sepsis, Burn
Sepsis Biomarker Monitoring in Burn Patients
The goal of this clinical trial is to learn if using pancreatic stone protein (PSP) test results helps doctors find and treat sepsis earlier in adults with serious burn injuries.
- Conditions
- Sepsis, Burn, Inflammation, Burn Infection
- Trial name
- NCT07866521
- Testing
- PSP Monitoring
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Texas Tech University Health Sciences Center
Sepsis, Acute Kidney Injury
A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis)
Biomarkers that provide an early indicator of kidney stress could be useful in clinical practice to detect silent episodes of acute kidney injury (AKI) or for early identification of subjects at risk of AKI.
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock
- Trial name
- LAPIS (NCT04434209)
- Testing
- Subject management guided by NephroCheck® test, Standard of Care
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 19 people
- Sponsor
- BioMérieux
Multiple Trauma
Inflammatory Response After Muscle and Skeleton Trauma
The purpose of this study is to determine the inflammatory response after multiple trauma in humans.
- Trial name
- IRAMST (NCT00710411)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Immunology of Septic Shock
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological Restoration (IMMUNOSEPSIS)
Septic syndromes (systemic inflammatory response associated with infection) remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units.
- Trial name
- IMMUNOSEPSIS (NCT02803346)
- Testing
- Circulating blood (leukocytes)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Shock
The high ratio of "central venous to arterial carbon dioxide" to "arterial to central venous oxygen content " is associated with elevated lactate in patients with septic shock.
- Trial name
- NCT04425161
- Testing
- Fluid challenge (0.9 % NaCl)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University