Clinical trials: Sepsis Biomarker
Sepsis, Bacteremia
Clinical Evaluation of Novel Biomarkers in Patients With Septicemia
The protein ST2 is a member of the interleukin-1 receptor family. Blood concentrations of the soluble isoform of ST2 (sST2) are increased in inflammatory and heart diseases and are considered a prognostic marker in both.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NOBIS (NCT01359891)
- Where
- Austria
- Volunteers
- 750 people
- Sponsor
- Medical University of Graz
Sepsis
Pro-adrenomedullin as a Prognostic Marker in Neonatal Sepsis
The aim of this study was to clarify the prognostic value of serum pro-Adrenomedullin level in neonatal sepsis. Eighty term and preterm neonates with sepsis were enrolled in this study.
- Trial name
- NCT01362504
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Sepsis, Autonomic Nervous System
Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children
The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions.
- Trial name
- DysREAped (NCT05807555)
- Testing
- Ambulatory ECG, Blood sample
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Critically Ill, Sepsis
Early Diagnostic Biomarkers of Sepsis
A Comparison between CRP, ferritin, and serum zinc as early diagnostic biomarkers of sepsis in critically ill patients
- Trial name
- NCT05112406
- Volunteers
- 70 people
- Sponsor
- Assiut University
Late-Onset Neonatal Sepsis
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- EMERAUDE (NCT03299751)
- Testing
- Diagnostic performances of biomarkers combination
- Where
- 2 sites in France
- Volunteers
- 233 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Intensive Care
Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU
The adequacy of early empiric antimicrobial therapy is an important factor in determining the outcome in patients with severe sepsis. The duration of adequate antibiotic therapy in these patients however is less clear.
- Trial name
- NCT00987818
- Testing
- Procalcitonin measurement
- Where
- Netherlands
- Sponsor
- Rijnstate Hospital
Infections, Infections - Bacterial
Human Neutrophil Lipocalin as an Aid in the Diagnosis of Bacterial Infection in the Emergency Department
The aim of this study is to improve the medical care of patients with infections for which the cause cannot be clearly identified as bacterial or viral.
- Conditions
- Infections, Infections - Bacterial, Viral Infection, Sepsis
- Trial name
- BEDS (NCT07796945)
- Where
- Switzerland
- Volunteers
- 516 people
- Sponsor
- University Hospital, Basel, Switzerland
Normal Control, SIRS
Sepsis Metabolomics
The occurrence of sepsis and its relevant multiple organ dysfunction remain a major problem in intensive care units with high morbidity and mortality.
- Conditions
- Normal Control, SIRS, Sepsis, Severe Sepsis
- Trial name
- NCT01649440
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Sepsis
Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and increased mortality.
- Trial name
- EMR3-SEPSIS (NCT07896018)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Sepsis, Newborn Sepsis
T6A Biomarker for Detection of Bacterial Infection in Newborn Infants
This bi-center study aims to assess the efficacy of a new biomarker, N6-threonylcarbamoyladenosine (t6A), for the early diagnosis of Early-Onset Sepsis (EOS) in newborns.
- Conditions
- Sepsis, Newborn Sepsis, Biomarker Discovery
- Trial name
- T6ASepsis (NCT07670624)
- Where
- 2 sites in Austria, Poland
- Volunteers
- 210 people
- Sponsor
- Salzburger Landeskliniken
Septic Shock
Septic Shock-induced Immunosuppression
Septic syndromes are a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units (ICU).
- Trial name
- IMMUNOSEPSIS 4 (NCT04067674)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 305 people
- Sponsor
- Hospices Civils de Lyon
Immunology of Septic Shock
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological Restoration (IMMUNOSEPSIS)
Septic syndromes (systemic inflammatory response associated with infection) remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units.
- Trial name
- IMMUNOSEPSIS (NCT02803346)
- Testing
- Circulating blood (leukocytes)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Disseminated Intravascular Coagulation (DIC)
Fluorescent Leukocytes as a Marker of Early Sepsis/Severity
Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient.
- Conditions
- Sepsis, Disseminated Intravascular Coagulation (DIC), Septic Shock
- Trial name
- FLAMES (NCT07585942)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Glucose Fluctuations in Sepsis
Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
To determine whether glucose fluctuations prior to antibiotic administration are associated with sepsis severity and poor clinical outcomes.
- Trial name
- NCT07234526
- Volunteers
- 105 people
- Sponsor
- Assiut University
Critically Ill Patients
Combined Determination of sTREM-1, PCT and CD64 in Diagnosing Sepsis
The purpose of this study is to determine wether the combined measurement of the soluble form of TREM-1, PCT and the determination of neutrophils CD64 expression could diagnose sepsis in critically ill patients.
- Trial name
- NCT02198950
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- Central Hospital, Nancy, France
Bloodstream Infections, Short Bowel Syndrome
Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
The purpose of this research study is to evaluate the effects (good and bad) of supplementation with Glutamine to that of a placebo (L-alanine), on your child and their Short Bowel Syndrome.
- Conditions
- Bloodstream Infections, Short Bowel Syndrome, Development, Nutrition
- Trial name
- NCT01576003
- Testing
- Glutamine, L-alanine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sepsis Syndrome
Metrology to Enable Rapid and Accurate Clinical Measurements in Acute Management of Sepsis
Sepsis is a life-threatening condition that arises when a dysregulated response to infection results in multi-organ dysfunction or failure. This can affect any organ, resulting in a diverse clinical presentation.
- Trial name
- SEPTIMET (NCT05338359)
- Testing
- Blood sample, Phone-call
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Acute Respiratory Distress Syndrome
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)
1. Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) 2. Research center: Single-center study. 3.
- Trial name
- NCT04552821
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tianjin Nankai Hospital
Infectious Disease, Fever
Validation of a Proteomic Signature and Assessment of Viremia in Children With Fever Without Source
The study is an observational blinded Validation study in pediatric patients below 3 years old with a diagnosis of Fever Without Source (FWS).
- Conditions
- Infectious Disease, Fever, Viremia
- Trial name
- NCT03224026
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm