Clinical trials: Sepsis Septic Shock
Septic Shock
Hemodynamic Resuscitation and Monitoring in Early Sepsis
"Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES Study)" involves recording of patient's medical data related to that has been collected as part of his/her routine medical care in ICU.
- Trial name
- HERMES (NCT04143035)
- Testing
- No Intervention
- Where
- 246 sites in India
- Volunteers
- 500 people
- Sponsor
- Tata Memorial Centre
Sepsis, Postoperative Complications
Risk Factors Identification of Sepsis and Septic Shock After Major Abdominal Surgery Based on Artificial Intelligence
The goal of this observational study is to identify the risk factors and build the early warning system of sepsis and septic shock after major abdominal surgery based on artificial intelligence.
- Trial name
- NCT06684340
- Testing
- Exposure to major abdominal surgery
- Volunteers
- 22,646 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Septic Shock
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis
The norepinephrine and vasopressin for rescue versus early vasopressin for vasopressor dependent sepsis (NoVa) is a phase 3, multicenter, open-label, randomized controlled trial comparing an early vasopressin initiation strategy…
- Trial name
- NoVa (NCT06464510)
- Testing
- Early Vasopressin, Norepinephrine and Vasopressin for Rescue
- Where
- 8 sites in Brazil
- Volunteers
- 2,800 people
- Sponsor
- Hospital do Coracao
Fluid Refractory Septic Shock, Septic Shock
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children.
- Trial name
- NCT07273526
- Testing
- Adrenaline, Dopamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Laiba Qamar
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Sepsis
Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane
Sepsis remains a global scourge. Before the SARS-CoV-2 pandemic, the World Health Organization estimated approximately 49 million cases annually, resulting in 11 million deaths.
- Trial name
- PLAQSIRIS (NCT06440317)
- Testing
- Hemofiltration membranes (the oXiris membrane® and the HF1400® membrane)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Critical Illness, ARDS
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.
- Conditions
- Critical Illness, ARDS, Septic Shock, Multiple Trauma
- Trial name
- Replenish (NCT03480555)
- Testing
- Replenish Protein, Standard protein
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdullah International Medical Research Center
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Hypotension
Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock
The Non-Invasive Cardiac Output Monitor (NICOM) is a non-invasive monitor capable of measuring cardiac output (CO) and cardiac index (CI), and stroke volume (SV) and stroke volume index (SVI) based on heart rate.
- Conditions
- Sepsis, Hypotension, Septic Shock
- Trial name
- NCT05630716
- Testing
- NICOM
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- University of Minnesota
Sepsis, Septic Shock
Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Shock
This study is a prospective, stepped-wedge implementation trial to test the effects of implementing a Clinical Decision Support (CDS) tool for prediction of septic shock in four Emergency Departments within a pediatric healthcare…
- Conditions
- Sepsis, Septic Shock, Emergencies
- Trial name
- NCT05065333
- Testing
- Septic Shock Clinical Decision Support, Clinical Diagnosis Only
- Where
- United States
- Volunteers
- 1,345 people
- Sponsor
- University of Colorado, Denver
Patients With Respiratory Failure and Shocked
Effect of Arterio-venous ECMO on Severe Sepsis and ARDS
To evaluate and compare the effect of immunoadsorption effect of A-V ECMO on course of sepsis weaning from inotropes, weaning from the ventilator, duration of ICU stays and effect on mortality rate in patients with septic shock…
- Trial name
- NCT04555798
- Testing
- Meropenem Injection, A-V ECMO
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Mohamed Gaber Allam
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
Septic Shock
Activated Protein C and Corticosteroids for Human Septic Shock
This study aims at comparing the efficacy and safety of recombinant human activated protein C to that of low dose of corticosteroids and at investigating the interaction between these drugs in the management of septic shock
- Trial name
- APROCCHS (NCT00625209)
- Testing
- recombinant human activated protein C and hydrocortisone and fludrocortisone
- Where
- 4 sites in France
- Volunteers
- 1,241 people
- Sponsor
- University of Versailles
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Severe Sepsis, Septic Shock
Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction
The trial enrolls patients with early severe sepsis or septic shock displaying at least one newly developed organ dysfunction and showing clinical evidence of pulmonary or abdominal infection.
- Trial name
- SCIENS (NCT02246595)
- Testing
- CaCP29
- Where
- 11 sites in Germany
- Volunteers
- 72 people
- Sponsor
- InflaRx GmbH
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Shock, Septic
Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator
The goal of this observational study is to learn about blood pressure response to the vasopressor drug vasopressin in people with septic shock.
- Trial name
- NCT06426407
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Sepsis, Septic Shock
Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis
The purpose of this prospective, non-interventional, multi-centre clinical study is to assess the clinical validity of the Heparin Binding Protein (HBP) assay for indicating the presence, or outcome, of severe sepsis (including…
- Conditions
- Sepsis, Septic Shock, Sepsis With Acute Organ Dysfunction
- Trial name
- NCT03113721
- Where
- 5 sites in United States
- Volunteers
- 571 people
- Sponsor
- Axis Shield Diagnostics Ltd