Clinical trials: Sepsis Syndromes
Systemic Inflammatory Response Syndrome, Sepsis
Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis
To assess the potential value of alpha-1-acid glycoprotein (AGP) for early diagnosis and prognosis of patients with sepsis, and then compared with C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC) counts…
- Trial name
- NCT01838525
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Neonatal Sepsis
Neonatal Sepsis and GBS Carriage Study
In the proposed study, the investigators plan to establish the burden of early onset (EO) neonatal sepsis in the newborn population born at Maela Refugee Camp over a two year period. Aims 1.
- Trial name
- NSS (NCT00861055)
- Where
- Thailand
- Volunteers
- 849 people
- Sponsor
- University of Oxford
Malaria
Trial to Evaluate CIS43LS in Healthy Adults
Background: People get malaria when they are bitten by an infected mosquito. Malaria can be serious and sometimes deadly. Although there are medicines to treat malaria, there is no vaccine that fully prevents infection.
- Trial name
- NCT04206332
- Testing
- VRC-MALMAB0100-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Septic Shock
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
- Trial name
- NCT03821714
- Testing
- Glucocorticoid combination therapy, Glucocorticoid
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Southeast University, China
Sepsis
Clinical Evaluation of the Effect of Metformin in Sepsis
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is considered a condition that arises when the body's response to an infection injures its own tissues and organs.
- Trial name
- NCT05979038
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- German University in Cairo
Septic Shock
Microcirculation Recruitment Using Albumin 20% and Terlipressin in Septic Patients
The aim of this study is to evaluate the effect of combining HSA 20% and terlipressin on the microcirculation in patients with septic shock using the following;- Microcirculation recruitment by Cytocam-IDF.
- Trial name
- NCT05080543
- Testing
- Albumin 20% and terlipressin
- Volunteers
- 36 people
- Sponsor
- Amany Mousa Salama Muhammed
Staphylococcal Infections, Meningitis
Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections
Methicillin-resistant Staphylococcus aureus (SA) is a major pathogen causing mainly health-care associated infections and, lately, also community acquired infections. Few treatment choices exist to treat these infections.
- Conditions
- Staphylococcal Infections, Meningitis, Sepsis, Pneumonia
- Trial name
- NCT00427076
- Testing
- Cotrimoxazole, Vancomycin
- Where
- 2 sites in Israel
- Volunteers
- 252 people
- Sponsor
- Rabin Medical Center
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
Sepsis
Endotoxin Activity Assay and Microcirculation in Severe Sepsis
Endotoxin is the major mediator of sepsis resulted from systemic inflammatory response syndrome induced by gram-negative bacteria infection.
- Trial name
- NCT02452138
- Testing
- Severe sepsis management
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Enterobacteriaceae Infections, Bacteremia
Infections Caused by ESbL-Producing Enterobacteriaceae in Italy
To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1.
- Conditions
- Enterobacteriaceae Infections, Bacteremia, Pneumonia, Skin Diseases
- Trial name
- NCT00404625
- Testing
- Risk factors for infections due to ESBL+ Enterobacteriaceae, Risk factors for inadequate initial antimicrobial therapy, Overall and 30-day mortality in bad first antibiotic therapy
- Where
- 6 sites in Italy
- Volunteers
- 813 people
- Sponsor
- University of Siena
Sepsis
Field Paramedic Application of Sepsis Triage
Given the implementation of the Hamilton Early Warning Score (HEWS) and the use of capnography by paramedics, this study will involve a large multi-site retrospective evaluation (before vs after implementation) of the HEWS score…
- Trial name
- FAST (NCT03870789)
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Hamilton Health Sciences Corporation
Sepsis
Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis
Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ…
- Trial name
- NCT02605681
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
BK Virus (BKV) Viremia
BK Virus Infection (Viremia) Natural History in Renal Transplant Recipients
The objectives of this study is to establish the natural history of BK virus viremia and other possible opportunistic viral pathogens in renal transplants recipients.
- Trial name
- NCT01782209
- Where
- 6 sites in United States
- Volunteers
- 335 people
- Sponsor
- University of Alabama at Birmingham
Intra-abdominal Infection, Critical Illness
Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection
Intra-abdominal candidiasis (IAC) is a frequent and severe fungal infection in critically ill patients, often diagnosed late. Its pathophysiology remains unclear, particularly regarding why some patients develop invasive…
- Conditions
- Intra-abdominal Infection, Critical Illness, Post-Op Infection, Immunization; Sepsis
- Trial name
- CANDIRIS (NCT07130799)
- Testing
- Immunomonitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Systemic Inflammatory Response Syndrome
Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients
Leptin is a hormone that plays a central role in food intake and energy balance. It is secreted by fat cells, released into the circulation and transported into the central nervous system (brain), where it regulates energy…
- Trial name
- NCT00893932
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Hadassah Medical Organization
New Onset Atrial Fibrillation, Severe Sepsis
Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock
Purpose/Objectives: Severe sepsis and septic shock are a common cause of new onset atrial fibrillation (NOAF) in the intensive care unit. Development of NOAF in this setting can prolong length of stay and increase mortality.
- Conditions
- New Onset Atrial Fibrillation, Severe Sepsis, Septic Shock
- Trial name
- NCT02668432
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.