Clinical trials: Sepsis Syndromes
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Sepsis
The Effect of rTEM in the Prognosis and Severity of Sepsis Induced ARDS
To observe the changes of plasma rTEM levels in patients with sepsis, sepsis induced ARDS, and to explore its clinical significance.
- Trial name
- NCT06063707
- Testing
- Taking peripheral blood
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Pneumonia, Urinary Tract Infections
BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU
The emergence and rapid worldwide spread of Extended- Spectrum Beta-Lactamase-producing enterobacteriaceae (ESBLE) both in hospital and community, led physicians, and notably intensivists, to prescribe more carbapenems…
- Conditions
- Pneumonia, Urinary Tract Infections, Bloodstream Infection
- Trial name
- BLUE-CarbA (NCT03147807)
- Testing
- betaLACTA® rapid diagnostic test
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections
Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection, Severe Infection, Pseudomonas Aeruginosa
- Trial name
- OPTIMISE (NCT05210387)
- Testing
- Duration of therapy
- Where
- 29 sites in Brazil
- Volunteers
- 107 people
- Sponsor
- Hospital Moinhos de Vento
Infection, Sepsis
Early Identification of SEPsis SIGNs in Emergency Department
Objective of SepSIGN project is to validate biomarkers able to predict the clinical worsening of patients freshly admitted at Emergency Department.
- Trial name
- SepSIGN (NCT04261621)
- Where
- 12 sites in United States, France and 1 more
- Volunteers
- 815 people
- Sponsor
- BioMérieux
Severe Sepsis
Glutamine Supplementation in Critically Ill Patients With Severe Sepsis
Severe sepsis is a common condition with high mortality and morbidity. A previous meta-analysis has demonstrated the safety of glutamine supplementation with suggestion of mortality and morbidity benefits in critically ill…
- Trial name
- CGH-GLU (NCT03048994)
- Testing
- Glutamine
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- Changi General Hospital
Septic Shock
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation.
- Trial name
- NCT04136080
- Testing
- vasopressors
- Volunteers
- 752 people
- Sponsor
- Fujian Provincial Hospital
Postoperative Complications
Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment
Brief Summary: The goal of this study is to implement and test an intelligent perioperative system (IPS) that in real-time predicts risk for postoperative complications using routine clinical data collected in electronic health…
- Trial name
- IDEALIST (NCT02741986)
- Testing
- Risk estimation
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
Dexamethasone, Glucocorticoids
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after breast cancer surgery, with removal of the breast (mastectomy).
- Conditions
- Dexamethasone, Glucocorticoids, Mastectomy, Breast Cancer
- Trial name
- DEX-MAS (NCT03125941)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis
Procalcitonin in Diagnosis of Bacterial Infections in Young Infants
A diagnostic accuracy study investigating the accuracy of procalcitonin in diagnosing invasive bacterial infections in your infants.
- Trial name
- NCT03509727
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- Belfast Health and Social Care Trust
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Septic Shock
REmote Ischemic COnditioning in Septic Shock
Septic shock remains a major public health problem in industrialized countries, with a mortality rate as high as 50%, largely related to multiple organ dysfunction.
- Trial name
- RECO-Sepsis (NCT03201575)
- Testing
- Remote Ischemic conditioning, Patients with no remote ischemic conditioning
- Where
- 6 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Incidence of Infectious Diseases
Enhanced Molecular Microbiological Surveillance Versus Ceftriaxone Prophylaxis in Hematopoietic Cell Transplant Patients
The goal of this clinical trial is to learn whether close microbiological monitoring without preventive antibiotics works as well as preventive treatment with ceftriaxone in adults receiving stem cell transplants.
- Trial name
- CRONOS (NCT07308457)
- Testing
- Ceftriaxone 1000 MG
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Acute Lung Injury, Systemic Inflammatory Response Syndrome
Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan
The purpose of this study is to confirm the efficacy and safety of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.
- Trial name
- NCT00219375
- Testing
- Sivelestat sodium hydrate
- Where
- 9 sites in Japan
- Volunteers
- 649 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Sepsis
The Potential of Mesenchymal Stromal Stem Cells to Correct Immune and Metabolic Dysfunctions in Circulating Immune Cells During Sepsis: An Ex Vivo Pilot Study.
Sepsis is a life-threatening organ dysfunction caused by the host's dysregulated immune response to infection. It represents a major global public health challenge.
- Trial name
- REPROCELL (NCT07812012)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Invasive Candidiasis, Candidemia
Genetic Susceptibility Factors for Candidemia.
This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia.
- Conditions
- Invasive Candidiasis, Candidemia, Genetic Predisposition to Disease
- Trial name
- NCT02841501
- Testing
- Analysis of genetic polymorphisms
- Where
- France
- Volunteers
- 453 people
- Sponsor
- University Hospital, Lille
Aortic Valve Disease, Surgery--Complications
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
There is considerable morbidity and mortality associated with cardiac surgery. Currently little effort is made to quantify how well the immune system of an individual can cope with inflammation or infection to which they are…
- Conditions
- Aortic Valve Disease, Surgery--Complications, Immune System Disorder
- Trial name
- Measure (NCT04430972)
- Testing
- Aortic valve replacement
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Sepsis, Thrombocytopenia
The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
Sepsis is life-threatening and dysregulated response to infection that results in endothelial activation and dysfunction that leads to systemic microvascular leak and multiple-organ failure.
- Trial name
- INFUSE (NCT03090919)
- Testing
- Platelet transfusion, Saline
- Where
- United States
- Sponsor
- Susan Smyth
Septicemia
Evaluation of an Internal Hospital Practice: The Effect of Altered Test Tubes Sampling Order on Blood Culture Contamination Rates
Implementation of the initial specimen diversion technique, in which the first milliliter of the venipuncture sample is not injected into the culture bottle, led to a significant reduction in blood culture contamination rates.
- Trial name
- NCT03088865
- Testing
- aspirating first blood volume into a regular blood collection tube
- Where
- Israel
- Volunteers
- 756 people
- Sponsor
- Hadassah Medical Organization
Immune System Diseases, Premature Infant Disease
Oral Colostrum and Its Effect on Immune System
The purpose of this project is to increase the serum immunological defenses of premature infants less then 32 weeks of gestation by administrating colostrum in the oropharyngeal mucosa versus placebo
- Conditions
- Immune System Diseases, Premature Infant Disease, Immunoglobulin Deficiency
- Trial name
- NCT03578341
- Testing
- Orally Colostrum
- Where
- 2 sites in Mexico
- Volunteers
- 96 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
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