Clinical trials: Sepsis Syndromes
Severe Sepsis
An Open Label Study of Severe Sepsis in Adults
This trial is to obtain safety data in adult patients with severe sepsis and two sepsis-induced organ infections who receive an infusion of drotrecogin alfa (activated).
- Trial name
- NCT00568893
- Testing
- drotrecogin alfa (activated)
- Where
- 18 sites in Belgium
- Volunteers
- 130 people
- Sponsor
- Eli Lilly and Company
Sepsis, Infection
Initial Feasibility Study of the CycloPE® Device
This is a single-center, prospective, single-arm clinical study to evaluate the feasibility, safety, and performance of the PATH EX CycloPE® device on suspected bacteremia-associated sepsis.
- Conditions
- Sepsis, Infection, Bacteremia Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- NCT06970899
- Testing
- PATH EX CycloPE® Device
- Where
- Armenia
- Volunteers
- 15 people
- Sponsor
- PATH EX, Inc.
Septic Shock, Shock
Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock
Norepinephrine is a catecholamine that is the first-line vasopressor for septic shock. The addition of non-catecholamine vasopressors, including vasopressin and angiotensin-II may be used in adults with septic shock that have…
- Conditions
- Septic Shock, Shock, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT06122987
- Testing
- Angiotensin II and hydrocortisone sodium succinate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kingman Regional Medical Center
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Neonatal Sepsis, Early-Onset
Performance of Interleukin-27 Cord Blood Level as A Biomarker Predicating Early Onset Neonatal Sepsis
Neonatal sepsis still considered as one of the major causes of mortality and morbidity during the neonatal period due to high vulnerability of that age group.
- Trial name
- NCT05589909
- Testing
- IL27, PCT, CRP, Blood culture
- Where
- United Arab Emirates
- Volunteers
- 548 people
- Sponsor
- Mansoura University Children Hospital
Sepsis
A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis
The aim of the study is to demonstrate if using one procalcitonin (PCT)-guided rule of stop of antimicrobials, the incidence of infections by C.difficile and by Multi-Drug-Resistant (MDR) bacteria during the next six months may…
- Trial name
- PROGRESS (NCT03333304)
- Testing
- Procalcitonin measurement
- Where
- 7 sites in Greece
- Volunteers
- 266 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Necrotizing Soft Tissue Infection, Fournier Gangrene
Necrotizing Soft Tissue Infections
SnapNSTI is an international, multicenter, time-bound prospective observational cohort study designed to characterize current epidemiology, management patterns, and outcomes of patients with necrotizing soft-tissue infections…
- Conditions
- Necrotizing Soft Tissue Infection, Fournier Gangrene, Sepsis, Surgical Infection
- Trial name
- SnapNSTI (NCT07107555)
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- European Society for Trauma and Emergency Surgery
Septic Shock
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Septic shock is one of the major causes of death worldwide with in-hospital mortality rates varying between (11.9% to 47.2 %). Alterations in microcirculatory blood flow were associated with high risk of organ dysfunction and…
- Trial name
- NCT03151668
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sepsis, Infections
Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the…
- Trial name
- NCT06973174
- Testing
- Premature neonates with invasive infection caused by Bacillus cereus
- Where
- 13 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Malaria
Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children
Background: The disease malaria can cause very serious health problems. Researchers want to see if malaria affects the way T cells and vaccines work in the body.
- Trial name
- NCT02504918
- Where
- Mali
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis
Omega-3 Fatty Acid for Critically Ill Patients.
Sepsis is the most common reason for intensive care unit (ICU) admission. Sepsis flares up the systemic inflammatory response with its mediators.
- Trial name
- NCT03388450
- Testing
- Omega 3
- Volunteers
- 110 people
- Sponsor
- Menoufia University
Sepsis, Tuberculosis
STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis
Sepsis, a life-threatening condition due to a dysregulated response to infection, is the leading cause of global mortality and is frequently driven by tuberculosis (TB) and drug-resistant bacteria in sub-Saharan Africa…
- Trial name
- STARS (NCT07332325)
- Testing
- Hydrocortisone administration, Expanded antimicrobial therapy
- Where
- 4 sites in Tanzania, Uganda
- Volunteers
- 344 people
- Sponsor
- University of Virginia
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Sepsis, Sepsis Syndrome
Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance
Sepsis is a condition with a high mortality. Septic patients are frequently difficult to identify because of their non-specific presentations.
- Conditions
- Sepsis, Sepsis Syndrome, Sepsis, Severe
- Trial name
- NCT03249597
- Testing
- Blood test: Glukos, SuPAR, Laktat and HBP
- Where
- Sweden
- Volunteers
- 956 people
- Sponsor
- Karolinska Institutet
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Sepsis
Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane
Sepsis remains a global scourge. Before the SARS-CoV-2 pandemic, the World Health Organization estimated approximately 49 million cases annually, resulting in 11 million deaths.
- Trial name
- PLAQSIRIS (NCT06440317)
- Testing
- Hemofiltration membranes (the oXiris membrane® and the HF1400® membrane)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Staphylococcus Aureus Bacteremia
Staphylococcus Aureus Bacteraemia in Adults
The purpose of this evaluation is to record the management and outcome of adults with S.aureus bacteraemia (SAB) across multiple European, Asian and North American sites and to identify key quality indicators associated with…
- Trial name
- ISAC (NCT02098850)
- Where
- 24 sites in Germany, South Korea and 3 more
- Volunteers
- 2,000 people
- Sponsor
- University of Cologne
Sepsis
HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis
Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
- Trial name
- NCT01847248
- Where
- China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sepsis
Sepsis in Geriatric Patients With Suspected Infection.
Sepsis is a complex clinical syndrome that has been defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Trial name
- NCT04945889
- Testing
- Quick Sequential Organ Failure Assessment (qSOFA), Modified Early Warning Score (MEWS), National Early Warning Score (NEWS)
- Where
- Italy
- Volunteers
- 580 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
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