Clinical trials: Sepsis Syndromes
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Septic Shock, Multiple Organ Failure
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study
Septic shock is defined as a subset of sepsis with severe metabolism alterations, leading to organ failure. Septic shock is associated with a high mortality, around 40% according to the SEPSIS 3 definition.
- Trial name
- MEFDASE (NCT04288635)
- Testing
- Whole blood samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Diet, Healthy, Endotoxemia
Different Dietary Patterns
The aim of the present study is to determine the effects of different standardized dietary patterns on general health markers, intestinal function, immune response and affective processes/ cognitive skills in healthy subjects.
- Trial name
- NCT06147440
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Vienna
ARDS
Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome Course
Investigation of effect of inhalation sedation by administration of Sevoflurane compared with Propofol on the moderate acute respiratory distress syndrome course in mechanically ventilated patients with sepsis.
- Trial name
- NCT04014218
- Testing
- Inhalation Sedation, Intravenous Sedation
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Sepsis, Thrombocytosis
Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients
Reactive or secondary thrombocytosis is defined as abnormally high platelet count (≥4,50,000 platelets per micro-liter) in the absence of chronic myeloproliferative disease.
- Conditions
- Sepsis, Thrombocytosis, Critically Ill
- Trial name
- NCT03531515
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Shock, Septic, Pituitary Dysfunction
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis.
- Conditions
- Shock, Septic, Pituitary Dysfunction, Hypopituitarism
- Trial name
- NCT05990491
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Neonatal Sepsis
Clinical Value of Metagenomic Sequencing in Neonatal Sepsis
This study aimed to enroll 2000 neonatal patients with suspected sepsis or clinical diagnosed sepsis. These patients will undergo both conventional methods and metagenomics sequencing to detect the pathogenic microorganisms of…
- Trial name
- NCT05416918
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
HIV Infections
A Multicenter, Exploratory Study to Evaluate the Effects of Antiretroviral Cessation on Plasma Associated HIV-1 RNA
To evaluate viral load in the blood stream of HIV-infected patients during a 28-day washout following cessation of long-term zidovudine ( AZT ) therapy.
- Trial name
- NCT00000840
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis
Efficacy Of Zinc Towards The Outcome on Children With Sepsis
Sepsis is a life-threatening organ failure induced by a compromised immune response to infection. Sepsis is a leading cause of morbidity and mortality (50-60%) in children treated in inpatient and critical care units.
- Trial name
- NCT06556511
- Testing
- Zinc Sulfate
- Where
- Indonesia
- Volunteers
- 140 people
- Sponsor
- dr. Aldora Jesslyn Oentari
Sepsis
Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)
Sepsis damages the blood vessel lining and its protective "glycocalyx," contributing to organ failure and death. This pilot, randomized, blinded study will test whether giving fresh frozen plasma (FFP)-either as intermittent…
- Trial name
- SPARES (NCT07160426)
- Testing
- Fresh Frozen Plasma (blood product), MVI and lactated ringers
- Volunteers
- 45 people
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
The Effect of Midazolam on Fluid Responsiveness in Septic Patients
Fluid resuscitation remains the foundation for septic treatment.The evaluation of fluid responsiveness has significance in volume resuscitation for septic shock patients.
- Trial name
- NCT02050893
- Testing
- sedatives(Midazolam and Propofol)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Sepsis, Acute Lung Injury
Statins for Acutely Injured Lungs From Sepsis
Objective: assess the efficacy and safety of oral rosuvastatin in patients with sepsis-induced Acute Lung Injury (ALI). Hypothesis: Rosuvastatin therapy will improve mortality in patients with sepsis-induced ALI.
- Trial name
- SAILS (NCT00979121)
- Testing
- Rosuvastatin
- Where
- 40 sites in United States
- Volunteers
- 745 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Necrotizing Enterocolitis, Sepsis
The Effects of Synbiotics on Morbidity and Mortality in Preterm Infants
Study, the inclusion of very low birth weight premature infants followed in Dr.Sami Ulus Maternity and Children Training and Research Hospital, Department of Neonatology; be randomized to very low birth weight premature infants…
- Trial name
- NCT01807858
- Testing
- Bifidobacterium lactis, Bifidobacterium lactis plus İnülin, Maltodextrin
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Sepsis
Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance
Critically ill patients with sepsis undergo several physiological alterations that can alter the distribution, metabolism, and elimination of drugs.
- Trial name
- NCT04147221
- Testing
- Imipenem-relebactam
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Hartford Hospital
Septic Shock
Early Albumin Resuscitation During Septic Shock
Objective: To determine whether the early administration of albumin as an expander and antioxidant would improve survival on the 28th day for septic shock patients.
- Trial name
- NCT00327704
- Testing
- albumin, saline
- Where
- France
- Volunteers
- 794 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Respiratory Failure, Sepsis
Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients
Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the…
- Conditions
- Respiratory Failure, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- EA-ICUAW (NCT02204215)
- Testing
- electric acupuncture, conservative
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Malaria
Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia
Background: The disease malaria affects many people in Liberia and other parts of Africa. It is caused by germs that are spread by mosquito bites.
- Trial name
- NCT03719599
- Where
- 2 sites in Liberia
- Volunteers
- 1,264 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Endotoxemia
Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans
A number of diseases lead to a so called systemic inflammatory response syndrome (SIRS). This excessive response is self-destructive and leads to major complications of the initial disease: dysfunction of the microcirculation…
- Trial name
- NCT00246714
- Testing
- repeated injections of endotoxin during 5 days
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study
Severe bacterial infections affecting multiple body organs, called severe sepsis (including meningococcal sepsis), remain an important cause of death and disability among children.
- Trial name
- StePS (NCT00732277)
- Testing
- hydrocortisone
- Where
- 3 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
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