Clinical trials: Sepsis Syndromes
Obesity, Sepsis
Adiposity and Immunometabolism in Sepsis
Obesity has been shown to increase adverse outcomes in some critically ill patients e.g. those with COVID-19. For patients with sepsis this association is less clear cut but there is evidence that body fat distribution, resulting…
- Trial name
- AIMS (NCT06307509)
- Testing
- Diagnosis of sepsis
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal
A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator
This study will review practices in relation to chorioamnionitis (CAM) before and after to the implementation of the Neonatal Early-Onset Sepsis (EOS) Risk Calculator to determine the effect in the nursery at Banner - University…
- Trial name
- NCT04513691
- Testing
- EOS Calculator
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Pediatrix
Sepsis, Altered Mental Status
Sepsis Associated Encephalopathy (SAE) Biomarkers
Sepsis associated encephalopathy (SAE) is a poorly understood acute cerebral dysfunction that frequently appears in the setting of sepsis induced systemic inflammation.
- Conditions
- Sepsis, Altered Mental Status, Sepsis-Associated Delirium, Sepsis Associated Encephalopathy
- Trial name
- NCT03133208
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Sepsis, Septic Shock
Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock
Sepsis is a term which describes an excessive response of the body to an infection and, if not promptly treated, can turn into septic shock a condition in which the organs don't receive enough oxygen to satisfy their needs.
- Trial name
- NCT06853574
- Testing
- Fluid therapy, Noradrenaline infusion
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- General and Teaching Hospital Celje
Endotoxemia, Systemic Inflammatory Response
PK/PD of EA-230 During Endotoxemia
EA-230 is a newly developed synthetic compound with anti-inflammatory properties. Pre-clinical data indicate that EA-230 may be a valuable treatment for systemic inflammation resulting from a variety of causes such as surgery…
- Trial name
- NCT02629874
- Testing
- EA-230, Endotoxin
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Precision Resuscitation With Crystalloids in Sepsis
Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis.
- Trial name
- PRECISE (NCT06253585)
- Testing
- Algorithm Alarm- Crystalloids, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 2,012 people
- Sponsor
- Emory University
Cardiac Arrest, Renal Failure
The Vital Signs to Identify, Target, and Assess Level (VITAL) Care Study III
To evaluate the effect of automated recording on frequency of recorded scores, number of automated notifications and serious events.
- Conditions
- Cardiac Arrest, Renal Failure, Respiration Failure, Myocardial Infarction
- Trial name
- NCT02973243
- Testing
- Automatic RR Measurement
- Where
- United Kingdom
- Volunteers
- 446 people
- Sponsor
- Philips Healthcare
Steatosis of Liver, Sepsis
The Role of Immune Semaphorins in Steatotic Liver Disease and Sepsis
The impact of the complex liver immunological network on sepsis outcome is largely unknown. Steatotic liver disease (SLD) is the most common chronic liver disease with prevalence of 25% in European countries.
- Conditions
- Steatosis of Liver, Sepsis, Immune Response
- Trial name
- SepsisFAT (NCT06021743)
- Testing
- Evaluation of the degree of steatosis, Screening for the components of metabolic syndrome, Measurement of serum semaphorin concentrations
- Where
- Croatia
- Volunteers
- 160 people
- Sponsor
- University Hospital for Infectious Diseases, Croatia
Fluid Refractory Septic Shock, Septic Shock
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children.
- Trial name
- NCT07273526
- Testing
- Adrenaline, Dopamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Laiba Qamar
Neonatal SEPSIS
Prevailing Microorganisms Causing Neonatal Sepsis in Neonatal Intensive Care Unit (Prospective Study)Prevailing Microorganisms Causing Neonatal Sepsis in Neonatal Intensive Care Unit (Prospective Study)
Prevailing microorganisms causing neonatal sepsis in neonatal intensive care unit of Assiut University children Hospital Methods prospective study conducted in the neonatal intensive care unit in Assiut university children…
- Trial name
- PMCNSINICUPS (NCT03308526)
- Volunteers
- 50 people
- Sponsor
- Gehad Abdelnaser
Septic Shock, Sepsis
The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
- Trial name
- NCT04644926
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 26 people
- Sponsor
- Lithuanian University of Health Sciences
Sepsis
An Acupuncture Study for People At High Risk for Sepsis
Researchers think acupuncture may improve outcomes for participants with sepsis, based on laboratory studies and previous studies in people with sepsis.
- Trial name
- ACTIONS (NCT06344819)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of California, Irvine
COVID-19
INB03 for the Treatment of Pulmonary Complications From COVID-19
The purpose of this study is to determine whether XPro1595 can prevent the progression of respiratory complications in COVID19 patients.
- Trial name
- NCT04370236
- Testing
- INB03
- Where
- 9 sites in United States
- Volunteers
- 79 people
- Sponsor
- Inmune Bio, Inc.
Sepsis, Septic Shock
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality.
- Conditions
- Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload
- Trial name
- TFC-SEPSIS (NCT06572995)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Bacterial Sepsis
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
: Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths.
- Trial name
- PLAQSEPSIS (NCT06657781)
- Where
- Guadeloupe
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Invasive Fungal Infection, Aspergillosis
Evaluate Three Methods for Diagnosis of Invasive Fungal Infection in Chinese Patients After HSCT
The purpose of this study is to assess the cut-off value of GM/G test in Chinese patients after hematopoietic stem cell transplantation, and evaluate GM/G test and real-time PCR for diagnosis of IFI in Chinese patients.
- Conditions
- Invasive Fungal Infection, Aspergillosis, Fungemia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT00460330
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Sepsis, Continuous Spinal Anesthesia
Continuous Spinal Anesthesia Versus General Anesthesia in Sepsis
The anesthetic efficacy and safety of continuous spinal anesthesia and comparing it with general anesthesia technique in sepsis diagnosed patient.
- Conditions
- Sepsis, Continuous Spinal Anesthesia, General Anesthesia
- Trial name
- NCT05897151
- Testing
- Continuous spinal anesthesia, General anesthesia
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mahmoud Rashad Ahmed
Perinatal Listeriosis
Neurological Consequences of Perinatal Listeriosis Infection
The purpose of the study is to determine whether perinatal listeriosis is associated with long-term neurological consequences, and to evaluate the respective contribution of perinatal sepsis, of prematurity and of the known…
- Trial name
- MONALISABABY (NCT02580812)
- Testing
- Clinical and neuropsychological evaluation procedure
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
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