Clinical trials: Sepsis Syndromes
Sepsis
Myeloid-derived Suppressor Cells in Sepsis
This study is designed for septic patients, to isolate MDSCs and the correlation of prognosis of sepsis. The purpose of this study hopes to explore the phenomenon and possible mechanisms of MDSCs in patients with severe sepsis.
- Trial name
- NCT03540797
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- Chung Fu-Tsai
Septic Shock, Methylene Blue
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the…
- Conditions
- Septic Shock, Methylene Blue, Sepsis
- Trial name
- NCT06481410
- Testing
- Methylene Blue Intervention Group, Normal Saline Control Group
- Where
- China
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bacteremia
Impact of BacT/Alert® VIRTUO®, BioFire® Blood Culture Identification 2-BCID2 and REVEAL® (bioMérieux) on the Optimization of Antibiotic Therapy for Gram-negative Bacteremia in the ICU
Bacteremia is a frequent infection in intensive care units. It is associated with a high mortality rate and the rapid implementation of appropriate antibiotic therapy is strongly correlated to patient clinical outcomes.
- Trial name
- BacteREVEAL (NCT05741424)
- Testing
- Innovative diagnostic technologies, Reference diagnostic technique
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Septicemia, Bacterial Infections
Efficacy and Safety of Colistin Based Antibiotic Therapy
To evaluate the efficacy and safety of antibiotic combinations containing Colistin in the treatment of children with multidrug-resistant gram negative infections admitted in the pediatric surgery intensive care unit.
- Trial name
- NCT04764058
- Testing
- Tienam 500, Infusion
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Bacteremia, Infection, Bacterial
Ertapenem for Initial Empirical Treatment of Third Generation Cephalosporin Resistant Enterobacteriaceae Bacteremia
This study aims to assess whether ertapenem as an empiric treatment of third-generation-cephalosporin resistant Enterobacteriaceae (3GCRE) bacteremia is non-inferior to other carbapenems in term of 30-day mortality.
- Trial name
- NCT03925402
- Testing
- Ertapenem, Carbapenems
- Where
- Thailand
- Volunteers
- 427 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Incidence of Infectious Diseases
Enhanced Molecular Microbiological Surveillance Versus Ceftriaxone Prophylaxis in Hematopoietic Cell Transplant Patients
The goal of this clinical trial is to learn whether close microbiological monitoring without preventive antibiotics works as well as preventive treatment with ceftriaxone in adults receiving stem cell transplants.
- Trial name
- CRONOS (NCT07308457)
- Testing
- Ceftriaxone 1000 MG
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Hepatorenal Syndrome
Treatment of Type-1 Hepatorenal Syndrome Associated With Sepsis
Type 1 Hepatorenal syndrome (type-1 HRS) is a severe complication of patients with advanced cirrhosis characterized by marked renal failure and is associated with a very poor prognosis.
- Trial name
- NCT01932151
- Testing
- Terlipressin and albumin
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Clinic of Barcelona
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Neutropenia, Febrile, Cancer
Remote Monitoring of Patients at Risk of Sepsis
Chemotherapy is used to treat cancer in many thousands of patients per annum in the United Kingdom and millions worldwide. Most chemotherapy suppresses bone marrow function and causes a low white cell count (neutropenia) which is…
- Conditions
- Neutropenia, Febrile, Cancer, Sepsis
- Trial name
- REACT (NCT04260230)
- Testing
- Lifetemp/Lifetouch sensors
- Where
- United Kingdom
- Sponsor
- The Christie NHS Foundation Trust
Sepsis
Administration of Protein C Concentrates in Adult Critically Ill Septic Patients
Severe sepsis and septic shock are life threatening medical emergencies and are among the most significant challenges in critical care.
- Trial name
- NCT01705808
- Testing
- Protein C concentrate
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Sepsis, Critical Illness
Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis
The hypothesis of this study is that bioenergetic failure in human sepsis, related to endocrine, metabolic and mitochondrial dysfunction, is a major determinant of defective host immune responses, increasing disease severity and…
- Trial name
- NCT00187824
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College London Hospitals
Critical Illness, Sepsis
Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Malnutrition is a frequent problem in critically ill patients that is associated with detrimental clinical outcomes. To provide adequate nutritional support, current studies focused mostly on the choice of delivery timing…
- Conditions
- Critical Illness, Sepsis, Diabetes, Cardiac Arrest
- Trial name
- NCT01753024
- Testing
- Enteral nutrition (EN)
- Where
- 2 sites in China
- Volunteers
- 362 people
- Sponsor
- Shanghai 10th People's Hospital
Bacteremia
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Participants With Staphylococcus Aureus Bacteremia Receiving Standard-of-Care (SOC) Antibiotics
This is a Phase Ib, randomized double-blind, placebo-controlled multiple-ascending dose study to investigate the safety, tolerability, and pharmacokinetics of multiple doses of DSTA4637S when given in addition to…
- Trial name
- NCT03162250
- Testing
- DSTA4637S, SOC
- Where
- 16 sites in United States, South Korea and 1 more
- Volunteers
- 27 people
- Sponsor
- Genentech, Inc.
Hematologic Cancer, CRS - Cytokine Release Syndrome
Early Detection of Complications During Immunotherapy for Haematological Malignancy
Aims To identify patients that should remain admitted in hospital for more intense surveillance because of high risk for development of clinical complications Expand the understanding of the interactions between physiology and…
- Trial name
- NCT06377059
- Testing
- WARD
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HIV Infections, Respiratory Tract Diseases
Botswana Pediatric Respiratory Disease and Bloodstream Infection Study
The purpose of this study is to learn about lower respiratory tract and bloodstream diseases among infants born to HIV positive mothers in Botswana.
- Conditions
- HIV Infections, Respiratory Tract Diseases, Sepsis
- Trial name
- NCT00197691
- Testing
- blood draws, etc.
- Where
- Botswana
- Sponsor
- Harvard School of Public Health (HSPH)
Critical Illness Myopathy, Myopathy Critical Illness
Understanding the Mechanisms of Critical Illness Myopathy by Use of a Novel Electrophysiological Method - MVRCs
Critical illness myopathy (CIM) is a disabling condition that develops in critically ill patients. The syndrome is not only a cause of prolonged intensive care hospitalisation but also a main reason for delayed recovery.
- Trial name
- NCT04711070
- Where
- 2 sites in Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Covid19
Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.
Given its anti-viral, anti-oxidative, immune-enhancing, cytokine-modulating, and anticoagulant properties, the investigators hypothesize that Selenium infusion at supranutritional doses for moderately-ill, severely-ill, and…
- Trial name
- SeCOVID (NCT04869579)
- Testing
- Selenium (as Selenious Acid)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CHRISTUS Health
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock
The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock
This study will include patients requiring high dose of norepinephrine (NA) to maintain blood pressure after fluid resuscitation.
- Trial name
- NCT04970602
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xiangya Hospital of Central South University
SARS-CoV-2, Influenza, Human
Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)
The purpose of this clinical trial is to evaluate the safety, tolerability and efficacy of two doses (dose A and dose B) of Standardized Conditioned Medium Obtained by Coculture of M2-macrophages and fat-derived Mesenchymal…
- Conditions
- SARS-CoV-2, Influenza, Human, Respiratory Syncytial Virus Infections, Respiratory Distress Syndrome
- Trial name
- NCT06684379
- Testing
- PRS CK STORM
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- PEACHES BIOTECH
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