Clinical trials: Sepsis Syndromes
Sepsis
Early Goal Directed Therapy in Sepsis by Emergency Medical Services
The goal is to evaluate the best way for paramedics and hospitals to work together to treat septic patients as quickly as possible.
- Trial name
- NCT02266654
- Testing
- IV fluids, Hospital Notification
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Endotoxemia, Intestinal Microbiota
Dietary Intervention to Reduce Metabolic Endotoxemia
The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and…
- Conditions
- Endotoxemia, Intestinal Microbiota, Dietary Habits, Clinical Trial
- Trial name
- NCT05776329
- Testing
- AIA-D, CONV-D
- Where
- 2 sites in Mexico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Sepsis
Symphony IL-6 Reference Range Study
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05048888
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bluejay Diagnostics, Inc.
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infections
The study will evaluate the efficacy and safety of Meropenem and Pralurbactam versus Best Available Therapy in the treatment of Carbapenem-Resistant Enterobacteriaceae Infections.
- Conditions
- Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP), Complicated Intra-abdominal Infection (cIAI), Complicated Urinary Tract Infection (cUTI)
- Trial name
- NCT07089186
- Testing
- Meropenem and Pralurbactam, Best Available Therapy (e.g., colistin, meropenem, tegecycline, amikacinceftezidime-avibatam)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Severe Sepsis
Hydrocortisone for Prevention of Septic Shock
Severe sepsis is a disease with a high mortality. Development of shock is a most serious complication and increases the risk of death considerably.
- Trial name
- HYPRESS (NCT00670254)
- Testing
- Hydrocortisone
- Where
- 30 sites in Germany
- Volunteers
- 380 people
- Sponsor
- Charite University, Berlin, Germany
Septic Shock, Sepsis
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
- Trial name
- ViCiS (NCT03835286)
- Testing
- Vitamin C
- Where
- Mexico
- Sponsor
- Hospital Español de Mexico
Septic Shock
Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients
We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.
- Trial name
- ClMLsepsis (NCT03700346)
- Testing
- microdialysis
- Where
- 2 sites in Tunisia
- Volunteers
- 73 people
- Sponsor
- Military Hospital of Tunis
Critically Ill, Acute Kidney Injury
Remote Ischemic Preconditioning in Septic Patients
Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis
- Trial name
- RIPC-ICU (NCT05830669)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Major Trauma, Sepsis
Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis
The occurrence of sepsis in trauma patients is a very serious complication. Identifying trauma patients at high risk of sepsis was not revealed in the latest surviving sepsis campaign in 2016.
- Trial name
- DrNoha-ICU (NCT04216459)
- Testing
- oral lactobacillus probiotics plus intramuscular cholecalciferol, intravenous vitamin C plus thiamine
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Mansoura University
Central Venous Catheter Related Infections
Comparison of Central Venous Catheters With Silver Nanoparticles Versus Conventional Catheters
Bloodstream infections are common in Intensive Care Units (ICUs). The need of a central venous line increases the risk of bacteremia and central venous catheter (CVC) related infections.
- Trial name
- NanoAgCVC (NCT00337714)
- Testing
- CVC impregnated with silver nanoparticles (AgTive®), CVC cannulation
- Where
- Italy
- Volunteers
- 472 people
- Sponsor
- Catholic University of the Sacred Heart
Sepsis, Septic Shock
The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis
The primary aim of this study is to assess the effects of adjunctive therapy with Interferon (IFN)-gamma on immune function in patients with septic shock in a placebo-controlled manner.
- Trial name
- NCT01649921
- Testing
- Interferon-gamma, Recombinant, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Radboud University Medical Center
Sepsis
Bioimpedance Analysis in Septic Intensive Care Unit (ICU) Patients
Patients with severe infections initially require large amounts of fluid as part of resuscitation. Later on however, problems may arise from excess fluid such as increased time on a ventilator and kidney damage.
- Trial name
- BIOVISION (NCT01379404)
- Testing
- Bioelectric Impedance Analysis
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Gram-Negative Bacterial Infections, Sepsis
A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in Adult
Sepsis sometimes occurs in people who have a serious infection. It is caused by toxic substances (toxins) from bacteria and other germs entering your bloodstream.
- Trial name
- NCT00563134
- Testing
- GR270774
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Hospital Authority, Hong Kong
Staphylococcus Aureus Infection
Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
Increasing resistance to antibiotic agents has been recognized as a major health problem worldwide that will even aggravate due to the lack of new antimicrobial agents within the next decade [1].
- Trial name
- SABATO (NCT01792804)
- Testing
- Trimethoprim-Sulfamethoxazole, Clindamycin, Linezolid
- Where
- 40 sites in France, Germany and 3 more
- Volunteers
- 215 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Bacteremia
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
The purpose is to investigate daptomycin pharmacokinetics in critically ill patients with suspected or verified bacteremia with Gram-positive cocci undergoing combined continuous hemodiafiltration at a filtration rate of…
- Trial name
- NCT01171547
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Cholangitis, Bacteremia
Factors Associated With Increased Risk of Bacteremia and Cholangitis in ERCP With Cholangioscopy
An Endoscopic retrograde cholangio pancreatography (ERCP) with cholangioscopy (endoscope to directly visualize the bile duct ) is a procedure (a small flexible tube that is inserted into the participants mouth to the participants…
- Trial name
- NCT02543957
- Testing
- Cholangioscopy
- Where
- United States
- Sponsor
- Baylor College of Medicine
Sepsis, Septic Shock
Adjuvant Use of Neostigmine in Sepsis and Septic Shock.
The inflammatory response represents an important, central component of sepsis. Therefore, it is believed that blunting inflammation will decrease mortality.
- Trial name
- NCT04130230
- Testing
- Neostigmine, Standard therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Sepsis, Acute Kidney Injury
Pharmacokinetics of Antibiotics in Critically Ill Patients Receiving CVVHF
The mortality in patients with sepsis and severe acute kidney injury requiring continuous renal replacement therapy (CRRT) remains high.
- Trial name
- NCT04800952
- Testing
- blood samples and filtered fluid will be collected.
- Volunteers
- 120 people
- Sponsor
- Osaka University
Sepsis, Fluid Overload
Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis
Sepsis is a common and life-threatening condition caused by a dysregulated host immune response to infection. Given the prominent role of endothelial breakdown and dysfunction in sepsis, therefore, there is an urgent need to…
- Conditions
- Sepsis, Fluid Overload, Endothelial Dysfunction, Microcirculation
- Trial name
- INITIALISE (NCT06626984)
- Testing
- Imatinib, Compound sodium lactate solution
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust