Clinical trials: Sepsis Syndromes
Sepsis, Septic Shock
Lactate Kinetics in Septic Shock
Lactate kinetics will be studied in hospitalized septic patients using a bolus injection of stable isotopically labeled lactate.
- Trial name
- LKISS (NCT05349370)
- Testing
- Isotopically labeled lactate
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Sepsis
Pharmacokinetics and Pharmacodynamics of Ceftazidime in Pediatric ICU Patients
Mortality benefit has been proven with early antibiotic administration in sepsis. Antimicrobial therapy should be based on early achievement of effective drug concentrations by optimizing the pharmacokinetic/pharmacodynamics of…
- Trial name
- NCT03133910
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Fungemia, Mycoses
Voriconazole as Prophylaxis for Liver Transplant Recipients
The study aims to determine if voriconazole prevents invasive fungal infections in liver transplant recipients. Endpoints would be: occurrence of invasive fungal infection and fungal colonization.
- Trial name
- NCT00177788
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage
The study aims to evaluate the suitability of the SOFA score implemented by the Sepsis 3 guideline to detect sepsis in patients suffering from subrarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Sepsis Syndrome, Sepsis
- Trial name
- NCT05246969
- Testing
- Sepsis detection
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Goethe University
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Septic Shock, Hemodynamic Instability
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand.
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Trial name
- NCT05225402
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Septic Shock, Sepsis
Effects of Paroxetine on Cardiovascular Function in Septic Patients
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction.
- Trial name
- NCT05725837
- Testing
- Paroxetine
- Where
- 2 sites in Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Still's Disease, Adult-Onset, Sepsis
Glycosylated Ferritin in Macrophagic Activation Syndromes
In healthy subjects, from 50 to 80 % of the serum ferritin is glycosylated [1, 2] . A decrease in the percentage of ferritin glycosylation can be observed in inflammatory diseases, malignancies, infections, or liver disease but…
- Conditions
- Still's Disease, Adult-Onset, Sepsis, Macrophagic Activation Syndrome
- Trial name
- FERRITGLY01 (NCT02143986)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Brugmann University Hospital
Sepsis, Fever
Procalcitonin in Diagnosing Bacteremia in the Emergency Department
Nowadays, a physician plays a more important role in managing patients with potential infectious complications in the emergency room.
- Trial name
- NCT00174122
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Aortic Aneurysm, Thoracic, Systemic Inflammatory Response Syndrome
A Pilot Study to Evaluate the Systemic Inflammatory Response of Thoracoabdominal Aortic Aneurysm Repair.
The purpose of this study is to look at the systemic inflammatory response caused when patients undergo thoracoabdominal aortic aneurysm repair (TAAA).
- Trial name
- NCT00739557
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock
The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock
This study will include patients requiring high dose of norepinephrine (NA) to maintain blood pressure after fluid resuscitation.
- Trial name
- NCT04970602
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xiangya Hospital of Central South University
Septic Shock, Sepsis
Vitamin C and Septic Shock
This is a randomized, double-blind, placebo-controlled clinical trial to compare Vitamin C versus placebo for patients presenting to the ICU with a diagnosis of septic shock.
- Trial name
- NCT03338569
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Covid-19, SARS
Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19
Some patients infected with the COVID-19 can develop uncontrolled immune response, leading to potentially life-threatening damage to lung tissue. Tocilizumab was first approved by the U.S.
- Conditions
- Covid-19, SARS, Cytokine Storm, Cytokine Release Syndrome
- Trial name
- TACOS (NCT04306705)
- Testing
- Tocilizumab, Standard of care, Continuous renal replacement therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji Hospital
Microbial Colonization, Extreme Prematurity
NICU Antibiotics and Outcomes Trial
The goal of the NANO trial is to study the longstanding clinical practice of empirically administering intravenous antibiotics to extremely low birthweight (ELBW) infants in the first days of life.
- Conditions
- Microbial Colonization, Extreme Prematurity, Early-Onset Neonatal Sepsis, Late-Onset Neonatal Sepsis
- Trial name
- NANO (NCT03997266)
- Testing
- Ampicillin, Gentamycin, Normal saline
- Where
- 14 sites in United States
- Volunteers
- 359 people
- Sponsor
- Michael Morowitz
Sepsis and Septic Shock
MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK
Sepsis-induced immunosuppression (SIS) is a common complication in patients with septic shock. Reduced expression of Human leukocyte antigen isotype DR (HLA-DR) on circulating monocytes is a marker for SIS and correlates with…
- Trial name
- MIRSEP (NCT07597122)
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis
Oxidative Monitoring in ICU Patients.
Sepsis is common in the ICU and is associated with high mortality that reaches up to 60%, increased duration of hospitalization and additional costs [1,2].Early diagnosis and stratification of severity are of great importance in…
- Trial name
- ORPICU (NCT02114853)
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Septic Shock
Vasopressin for Septic Shock Pragmatic Trial
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure.
- Trial name
- VASSPR (NCT06217562)
- Testing
- Vasopressin, Recommendation to use a lower initiation threshold for vasopressin, Recommendation to use a higher initiation threshold for vasopressin
- Where
- 13 sites in United States
- Volunteers
- 3,959 people
- Sponsor
- Intermountain Health Care, Inc.
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.