Clinical trials: Sepsis Syndromes
Septic Shock, Thrombocytopenia
Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children
The purpose of this study is to learn how blood clotting substances respond in children with septic shock, low platelet counts, and multiple organ failure (MOF) treated at different institutions.
- Conditions
- Septic Shock, Thrombocytopenia, Multiple Organ Failure
- Trial name
- TAMOF (NCT00118664)
- Where
- 12 sites in United States
- Volunteers
- 86 people
- Sponsor
- Children's Healthcare of Atlanta
Sepsis
Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis
In this study, our aim is to investigate the role tranexamic acid in modulating inflammation in patients with sepsis.
- Trial name
- NCT04910464
- Testing
- Tranexamic acid, 0.9% saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Acute Kidney Injury Due to Sepsis (Disorder)
A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock
The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related organ failure assessment…
- Trial name
- NCT04073771
- Testing
- Continuous renal replacement therapy with oXiris
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Southeast University, China
Sepsis, Shock, Septic
Medical Education for Sepsis Source Control and Antibiotics
Patients with severe sepsis or septic shock suffer from life-threatening infections. Fast and adequate therapy with antibiotics is crucial for survival.
- Trial name
- MEDUSA (NCT01187134)
- Testing
- Change Management
- Where
- 42 sites in Germany
- Volunteers
- 4,138 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Hypovitaminosis D
Cholecalciferol Supplementation for Sepsis in the ICU
Sepsis in a clinical entity that occurs in patients with serious infections. Though the severity of illness may vary, every year, approximately 1.6 million Americans are treated for sepsis.
- Trial name
- CSI (NCT01896544)
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Sepsis
Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis
Meta-and ortho-Tyrosine are known markers of oxidative stress, while the physiological isomer, para-Tyrosine is suggested the antagonize the effects of meta- and ortho-Tyrosine.
- Trial name
- NCT03278730
- Testing
- Para-Tyrosine supplementation
- Where
- 2 sites in Hungary
- Volunteers
- 296 people
- Sponsor
- University of Pecs
Percutaneous Nephrolithotomy, Infection
Conventional Antibiotic Prophylaxis Versus Add-On 5 Days Levofloxacin Before Percutaneous Nephrolithotomy
To evaluate whether 5 days of levofloxacin before percutaneous nephrolithotomy (PCNL) in reducing upper urinary tract infection and urosepsis after PCNL.
- Conditions
- Percutaneous Nephrolithotomy, Infection, Sepsis, Antibiotics
- Trial name
- NCT03178292
- Testing
- Levofloxacin
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Mansoura University
Sepsis, Infection
Evaluation of the Heparin Binding Protein Levels in Sepsis
Present criteria used to define sepsis are non-specific, making it difficult to both distinguish sepsis from other diseases and to predict which patients are likely to become more severely ill.
- Conditions
- Sepsis, Infection, Septic Shock
- Trial name
- HBP (NCT02533011)
- Testing
- HBP lab test
- Where
- United States
- Volunteers
- 1,055 people
- Sponsor
- Christiana Care Health Services
Infective Endocarditis
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study
Introduction. Comprehensive data on infective endocarditis in developing countries are scarce. Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis…
- Trial name
- EndoDev (NCT02128139)
- Where
- 6 sites in Fiji, Laos and 3 more
- Volunteers
- 300 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Septic Shock
Midodrine in the Recovery Phase of Septic Shock
The aim of this study is to investigate the role of oral midodrine in the recovery of septic shock. The investigators hypothesize that the oral drug can reduce central line days and ICU length of stay.
- Trial name
- NCT02990546
- Testing
- midodrine, Standard of Care
- Where
- United States
- Sponsor
- University of Virginia
Bacteremia
Surveillance of AMR in DRC
This study addresses knowledge gaps regarding antimicrobial resistance (AMR) in sub-Saharan Africa, focusing on evaluating the feasibility of AMR surveillance and enhancing local research capacity.
- Trial name
- SARKIN (NCT06821282)
- Where
- Democratic Republic of the Congo
- Volunteers
- 210 people
- Sponsor
- University of Oxford
Septic Cardiomyopathy
Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy Using an Integrated Mathematical Model
The goal of this observational study is to evaluate whether a new integrated mathematical model can improve the accuracy of diagnosing septic cardiomyopathy and predicting clinical outcomes in adult patients with suspected septic…
- Trial name
- NCT06793020
- Where
- 2 sites in Lithuania, Poland
- Volunteers
- 100 people
- Sponsor
- Vilnius University
Shock, Septic, Sepsis
Balanced Salt Solution VS. Normal Saline Solution in Septic Shock
The Purpose of this study is to determine the impact of balanced salt solution versus chloride rich solution on clinical outcomes in paediatric severe sepsis or septic shock
- Trial name
- NCT02336620
- Testing
- Ringer acetate, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Neonatal Sepsis, Low Birth Weight
Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
The purpose of this study is to examine if single skin cleansing with 0.25% chlorhexidine affects skin condition, temperature, and bacterial colonization in stable preterm (28-36 weeks gestational age) low birth weight (1001-2000…
- Trial name
- NCT00947518
- Testing
- Chlorhexidine, Normal saline
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Sepsis
Clinical Research on Shenfu Injection in Septic Patients
Sepsis, characterized by organ dysfunction caused by infection, exhibits increasing incidence and mortality rates, posing a significant challenge to intensive care units.
- Trial name
- NCT06157320
- Testing
- Shen-Fu, Norepinephrine (NE)，antibiotics，fluid resuscitation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Hypotension
Efficacy Study of a Facemask Device to Treat Hypotension
The purpose of this study is to determine if the impedance threshold device (ITD) attached to a facemask can increase blood pressure in patients who present to the emergency department with hypotension secondary to hypovolemia.
- Trial name
- NCT00256724
- Testing
- Impedance Threshold Device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Advanced Circulatory Systems
Sepsis
The Role and Mechanism of Vimentin in Sepsis Patients
Sepsis is the most common cause of death in the clinical critically ill patients. We have successfully screened the sepsis biomarkers by clinical proteomics approach and found that Vimentin (VIM) played an important role in the…
- Trial name
- NCT03253146
- Testing
- VIM detection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Intensive Care Unit Acquired Weakness, Shock, Septic
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2
Over-resuscitation including fluid overload has been associated with increased morbidity (prolonged duration of organ failure) and mortality in septic shock.
- Trial name
- ANDROMEDA-FR (NCT06062303)
- Testing
- Usual care (UC)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fungemia, Mycoses
Voriconazole as Prophylaxis for Liver Transplant Recipients
The study aims to determine if voriconazole prevents invasive fungal infections in liver transplant recipients. Endpoints would be: occurrence of invasive fungal infection and fungal colonization.
- Trial name
- NCT00177788
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
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