Clinical trials: Sepsis Syndromes
Septic Shock, Cirrhosis, Liver
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response. A Subset of sepsis is septic shock which has almost 4-6 times the mortality when compared to sepsis.
- Trial name
- NCT05315557
- Testing
- Terlipressin, vasopressin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Sepsis
Prebiotic Fiber to Prevent Pathogen Colonization in the ICU
This is a pilot trial testing enteral feeds that are high versus low in prebiotic fiber in 20 critically ill adults. The long-term goal is to determine the efficacy of fiber for the prevention of pathogen colonization/infection…
- Trial name
- NCT03509753
- Testing
- High Fiber, Low Fiber
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Sepsis
The Efficacy of YiQiFuMai Injection as an Adjunctive Treatment for Sepsis
This is a prospective single center pilot randomized controlled study to assess the efficacy and safety of YiQiFuMai injection (YQFM), a widely used Chinese medicine, as an adjunctive treatment for sepsis.
- Trial name
- NCT05265130
- Testing
- YiQiFuMai, 0.9% Normal Saline 250ml
- Volunteers
- 80 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Septic Shock
Hypotension in the Weaning From Vasopressor Drugs
Although there is consensus in the literature on hemodynamic management of septic shock in the resuscitation phase, the best way to conduct the weaning of vasopressor drugs in the stabilization phase remains open.
- Trial name
- RENOVA (NCT05506319)
- Testing
- Norepinephrine, Vasopressin
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Septic Shock
Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock
The purpose of this research study is to determine whether patients who receive thiamine (vitamin B1), vitamin C and hydrocortisone while in septic shock have improved outcomes compared to hydrocortisone alone.
- Trial name
- NCT03540628
- Testing
- Thiamine and Vitamin C
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Corewell Health South
Neonatal Sepsis, Neonatal Mortality Rate
Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth
Purpose of this study is determine if skin application of chlorhexidine at birth would reduce infection in infants weighing <1500 g at birth.
- Trial name
- CAPS (NCT01723501)
- Testing
- 0.25% chlorhexidine, sterile water
- Where
- 3 sites in India
- Sponsor
- All India Institute of Medical Sciences
Bloodstream Infection
Genotypic Versus Phenotypic Susceptibility Testing of Positive Blood Cultures
This study is designed as a prospective, randomized, open-label trial evaluating antimicrobial utilization, clinical outcomes, and healthcare costs among patients with positive blood cultures.
- Trial name
- NCT03744728
- Testing
- Accelerate PhenoTest™ BC kit, Standard of Care
- Where
- United States
- Volunteers
- 774 people
- Sponsor
- Accelerate Diagnostics, Inc.
Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant
IgM-Enriched Immunoglobulin for Neonatal Sepsis
This study compares giving prophylactic IgM enriched Intravenous Immunoglobulin (IVIG) with placebo in 1 hour after birth, in neonates with risk factors of Early-Onset Neonatal Sepsis (EONS).
- Conditions
- Neonatal Sepsis, Early-Onset, Very Low Birth Weight Infant, Inflammation, Infant, Newborn, Disease
- Trial name
- NCT04041765
- Testing
- IgM-enriched IVIG
- Volunteers
- 70 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia
Hospital-acquired Pneumonia in Intensive Care Unit
hospital-acquired pneumonia are a common disease in intensive care unit. The prevention, the diagnosis and the treatment of hospital acquired pneumonia are a frequent challenge.
- Conditions
- Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia, Sepsis, Pneumonia
- Trial name
- PNEUMOCARE (NCT03348579)
- Testing
- Guidelines publication and application, Targeted experience feedback
- Where
- France
- Volunteers
- 1,850 people
- Sponsor
- Nantes University Hospital
Sepsis, Hemodialysis
Evaluation of Microbial and Endocrinological Parameters in Dialysis Patients With Sepsis
This prospective study aims to evaluate the diagnostic value and reliability of blood cultures obtained from different sources-central venous catheter (CVC), dialysis machine, and peripheral vein-in hemodialysis patients with…
- Trial name
- NCT06963853
- Testing
- Blood cultures will be obtained from three sources: 1. The central venous catheter (CVC), 2. The dialysis machine circuit, and 3. A peripheral vein
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Western Galilee Hospital-Nahariya
Sepsis
POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock
Septic shock is a major cause of morbidity and mortality. SIRS (systemic inflammatory response syndrome) can progress over hours to days to severe sepsis and septic shock.
- Trial name
- NCT03953404
- Testing
- SPLA2-IIA
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Sepsis, Septic Shock
Days Alive and Out of Hospital for Patients With Sepsis
We will perform a retrospective cohort study to assess the construct validity and performance of days alive and out of hospital at day 90 (DAOH90) in cohorts of patients with sepsis and septic shock who have been included in…
- Trial name
- NCT04567433
- Testing
- Hydroxyethyl starch, Hydrocortisone, Early Goal Directed Therapy
- Where
- Australia
- Volunteers
- 6,213 people
- Sponsor
- The George Institute for Global Health, Australia
Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors
The main goals of this study are to provide a cognitive, neurological, brain morphological, and serological profile of sepsis survivors in order to make long-term prognosis of recovery and estimate the need for rehabilitation…
- Trial name
- BonSEP (NCT02339649)
- Testing
- Blood Sample, Neurocognitive Assessment, Resting State EEG
- Where
- 2 sites in Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Trauma, Inflammation
Transcriptomic Profiling in Severely Injured Patients
Discovery of differences in the host response in patients with systemic inflammation and sepsis, and identification of novel, specific markers by using a longitudinal clinico-transcriptomic approach.
- Conditions
- Trauma, Inflammation, Sepsis
- Trial name
- NCT02508272
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- University of Zurich
Sepsis, Septic Shock
The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients
This clinical trial aims to evaluate the effect of dexmedetomidine in Sepsis-Associated Acute Kidney Injury in critically ill patients by answering the following questions: 1.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06570187
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Cairo University
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT
Bacteremia is a leading cause of mortality and morbidity in critically ill adults. Although bacteria in the bloodstream (bacteremia) may arise from variable infectious foci (most commonly central vascular catheter related, lung…
- Trial name
- BALANCE (NCT02261506)
- Testing
- 7 days of adequate antibiotic treatment durations, 14 days of adequate antibiotic treatment durations
- Where
- 17 sites in Canada
- Volunteers
- 115 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Infection
The Extended Study of Prevalence of Infection in Intensive Care IV
The goal of this observational study is to learn how common infections are in intensive care units (ICUs) around the world and how they are treated. The study will look at all adults in the ICU during a single 24-hour period.
- Trial name
- EPIC IV (NCT07309549)
- Volunteers
- 10,000 people
- Sponsor
- Universidad de la Sabana
Urinary Tract Infections, Sepsis
Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis
The purpose of the study is to investigate whether the use of gentamicin-based irrigation fluid during ureteroscopy decreases the risk of UTIs and other post-operative infections after surgery.
- Trial name
- NCT06007352
- Testing
- Gentamicin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.