Clinical trials: Sepsis Syndromes
Neonatal SEPSIS
Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death
Though maternal and neonatal health are high priority areas for international development, maternal and neonatal mortality remain unacceptably high.
- Trial name
- PregnAnZI-2 (NCT03199547)
- Testing
- Azithromycin
- Where
- 2 sites in Burkina Faso, The Gambia
- Volunteers
- 11,985 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cytokine Release Syndrome, ICANS
Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy
This study will evaluate the use of siltuximab to decrease the severity of cytokine release syndrome (CRS) and immune effector cell-associated neurological syndrome (ICANS) in patients who will receive chimeric antigen receptor…
- Conditions
- Cytokine Release Syndrome, ICANS, Lymphoma, Non-Hodgkin, Multiple Myeloma
- Trial name
- NCT04975555
- Testing
- Siltuximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Sepsis, Oxidative Stress
Sepsis and Thiol-Disulfide Balance in Emergency Department
The aim of this study was to determine the effectiveness of thiol-disulfide homeostasis in predicting diagnosis and mortality in sepsis patients, and to compare it with other inflammatory markers.
- Trial name
- NCT07134868
- Testing
- Thiol- Disulfide Blood Sample Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Bacteremia
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
The purpose is to investigate daptomycin pharmacokinetics in critically ill patients with suspected or verified bacteremia with Gram-positive cocci undergoing combined continuous hemodiafiltration at a filtration rate of…
- Trial name
- NCT01171547
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Sepsis, Thrombocytopenia
rhTPO in Critical Patients With Thrombocytopenia
The primary objectives of this study are to assess the impact of rhTPO on mortality among severe sepsis patients with thrombocytopenia, as well as changes of platelet counts and platelet transfusion rates.
- Trial name
- NCT02094248
- Testing
- TPO, control
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Jinling Hospital, China
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Septic Shock
Focused Ultrasound in Septic Shock Patients
The investigators hypothesize that lung ultrasound and echocardiography will benefit the septic shock patients by making the treatment more precisely and rapidly.
- Trial name
- NCT01920776
- Testing
- ultrasound examination, Ultrasound group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis
Effect of SRT2104 on Endotoxin-induced Inflammation
SRT2104 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice.
- Trial name
- NCT01014117
- Testing
- SRT2104
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sepsis, Acute Lung Injury
Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome
This is a prospective, randomized (1:1), double-blind, multi-center, Phase II clinical study to test the safety and efficacy of a recombinant chimeric anti-tissue factor antibody (ALT-836) versus placebo in patients with sepsis…
- Conditions
- Sepsis, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT00879606
- Testing
- ALT-836
- Where
- 20 sites in United States
- Volunteers
- 150 people
- Sponsor
- Altor BioScience
Sepsis, Lactate Blood Increase
Blood Lactate Level for Pre-hospital Orientation of Septic Shock
In the pre-hospital setting, the severity assessment of septic shock is essential to decide the optimal initial in-hospital level of care.
- Trial name
- LAPHSUS (NCT03831685)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hôpital Necker-Enfants Malades
COVID-19
Plasma Exchange in Covid-19 Patients With Anti-interferon Autoantibodies
COVID-19 associated mortality remains high despite the advances in therapeutics such as dexamethasone. The severity of COVID-19 results from direct viral cytotoxicity, and the inflammatory response, which is associated with a…
- Trial name
- EPIC (NCT05182515)
- Testing
- Therapeutic plasma exchange
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Sepsis
Management of Sepsis in Resource Limited Settings Using a Delphi Method.
Rapid evolution of sepsis syndromes means that timely diagnosis and treatment are critical in improving outcomes but this may be difficult to achieve in many low- and middle- income countries (LMICs) and there is a lack of high…
- Trial name
- NCT05909384
- Testing
- Survey
- Where
- Vietnam
- Volunteers
- 36 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Sepsis, Hypovolemia
The Impact of Focused Transthoracic Echocardiography in Urgent Abdominal Surgery for Septic Patients
The aim of the study is to identify the diagnostic value of the focused assessed echocardiography in septic patients undergoing urgent abdominal surgery due to peritonitis.
- Conditions
- Sepsis, Hypovolemia, Peritonitis
- Trial name
- ECHOCARD (NCT02846948)
- Testing
- Focused assessed echocardiography
- Where
- Lithuania
- Volunteers
- 131 people
- Sponsor
- Lithuanian University of Health Sciences
Morality
Anticardiolipin Autoantibodies and Mortality in Septic Patients
The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis and their responsibility for a wide spectrum of clinical manifestations such as…
- Trial name
- aCLsepsis (NCT04685278)
- Testing
- Blood samples
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Sepsis
Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients
To evaluate the dynamic alterations of Th2/Th1 for the prediction of clinical immunity and how it was related to 28 day-prognosis and ICU-acquired infections among critically ill patients of community-acquired severe sepsis with…
- Trial name
- NCT02883218
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jianfeng Xie
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Sepsis
Precision Resuscitation With Crystalloids in Sepsis
Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis.
- Trial name
- PRECISE (NCT06253585)
- Testing
- Algorithm Alarm- Crystalloids, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 2,012 people
- Sponsor
- Emory University
Severe Sepsis
Plasma Exchange in Children With Severe Sepsis and Septic Shock
The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone.
- Trial name
- PE/Sepsis (NCT07706413)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
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