Clinical trials: Sepsis Syndromes
Sepsis, Septic Shock
De-resuscitation Informed by Ultrasound for Patients With Sepsis
Randomized, unblinded clinical trial of 152 critically ill patients with sepsis admitted to the intensive care unit. The primary determine if using the Venous Excess Ultrasound Score (VExUS) to guide fluid deresuscitation in…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Volume Overload
- Trial name
- DRI-US (NCT04921319)
- Testing
- VExUS score
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The Miriam Hospital
Sepsis
Role of Enteral Lactoferrin as an Adjuvant for Prevention of Sepsis Among Preterm Neonates
Lactoferrin (LF) is a multifunctional glycoprotein and is naturally present in various body secretions, including human milk, tears, saliva, airway mucus, and the secondary granules of neutrophils 1-2.
- Trial name
- NCT07480434
- Testing
- Bovine Lactoferrin Supplement
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Zartash Sial Paeds Med
Bacteremia
Efficacy of 2% Chlorhexidine Gluconate in 70% Alcohol Compare 10% Povidone Iodine in Blood Culture in Children
To evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.
- Trial name
- NCT01919593
- Testing
- 2% chlorhexidine gluconate in 70% alcohol, 10%povidone iodine
- Where
- Thailand
- Volunteers
- 1,269 people
- Sponsor
- Thammasat University
Severe Sepsis or Septic Shock
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)
Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition.
- Trial name
- PITSTOP (NCT03068741)
- Testing
- Comparison 1: Prehospital Ceftriaxone, Comparison 2: Liberal fluids, Comparison 2: Conservative fluids
- Where
- 4 sites in Canada
- Volunteers
- 2,061 people
- Sponsor
- Dr. Damon Scales
Escherichia Coli Bloodstream Infection
Prognostic Factors of Escherichia Coli Bloodstream Infections: Severity Score and Therapeutic Implications
The determinants associated with severe outcome and death from Escherichia coli bloodstream infections (BSI) remain poorly understood. The epidemiology of E.
- Trial name
- SEPTICOLI (NCT02890901)
- Where
- France
- Volunteers
- 553 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Septicemia
Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia
Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique…
- Trial name
- SEPSIS2016 (NCT03943719)
- Testing
- FilmArray blood culture identification panel
- Where
- Belgium
- Volunteers
- 139 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Systemic Inflammatory Response Syndrome
Modulation of Molecular Fingerprinting in Pediatric Sepsis
The goal of this study is to demonstrate the sensitivity and specificity of detecting circulating micro RNA (miRNA) biomarkers in pediatric septic patients.
- Trial name
- NCT02055105
- Testing
- miRNA in Sepsis
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Phoenix Children's Hospital
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Effect of the Intensity of Continuous Renal Replacement Therapy
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Trial name
- NCT01251081
- Testing
- extra high volume hemofiltration, high volume hemofiltration
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Zhejiang University
Neutropenia, Fever
Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia
The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.
- Conditions
- Neutropenia, Fever, Bacterial Infection, Fungal Infection
- Trial name
- NCT02544230
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne
Sepsis, Septic Shock
Association of EASIX in Sepsis
This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.
- Conditions
- Sepsis, Septic Shock, Septic Syndrome
- Trial name
- NCT06887439
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Cognitive Impairment, Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
Long-term cognitive dysfunction greatly influences patient's quality of life after critical illness. However,its neurophysiological basis remains unknown.This is a 3 year fMRI study conducted at the Jiangyin people's Hospital.
- Conditions
- Cognitive Impairment, Functional Magnetic Resonance Imaging, Septic Shock, Inflammation
- Trial name
- NCT03946839
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jian-jun Yang
Endotoxemia, Metabolic Syndrome
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity…
- Conditions
- Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance
- Trial name
- Phenulin (NCT03800277)
- Testing
- Cranberry, Agaves
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Laval University
Sepsis, Trauma
Critical Care Excellence in Sepsis and Trauma
The care of patients with sepsis and trauma requires the delivery of appropriate definitive care in the early stages of the illness.
- Trial name
- CREST (NCT01426711)
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Medical University of South Carolina
Septic Shock
A Retrospective Review of a Comprehensive Cohort of Septic Shock: Assessment of Critical Determinants of Outcome
Septic shock remains the dominant cause of death in ICU's of the developed world with approximately 400,000 cases annually in the US and another 20,000 annually in Canada.
- Trial name
- NCT01775956
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of Manitoba
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
This was a Phase 3 study containing a randomized open-label superiority cohort (Cohort 1) comparing the efficacy and safety of plazomicin with colistin when combined with a second antibiotic (either meropenem or tigecycline) in…
- Conditions
- Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE, Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE, Complicated Urinary Tract Infection (cUTI) Due to CRE
- Trial name
- CARE (NCT01970371)
- Testing
- plazomicin, colistin, meropenem
- Volunteers
- 69 people
- Sponsor
- Achaogen, Inc.
Acute Respiratory Distress Syndrome
Mesenchymal Stem Cells (MSCs) and Conditioned Medium Mesenchymal Stem Cells as Adjuvant Therapy for Sepsis
This study was conducted to determine the effect of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) and Secretome in severe ARDS patients.
- Trial name
- NCT07439848
- Testing
- Control (NaCl 0.9%), UC-MSC, UC-MSC and Secretome
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Right Heart Failure, Unspecified, Critical Illness
Echocardiographic Evaluation of RV Injury in the ICU
The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome.
- Conditions
- Right Heart Failure, Unspecified, Critical Illness, ARDS, Human, Septic Shock
- Trial name
- RECHOicu (NCT05525936)
- Testing
- Echocardiography and central venous pressure
- Volunteers
- 440 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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