Clinical trials: Sepsis Syndromes
Septic Shock, Severe Sepsis
GM-CSF to Decrease ICU Acquired Infections
The concept of acquired immunodeficiency after a first severe infection in the ICU is widely described in the literature. There is a dual risk: increased mortality and increased secondary infections.
- Trial name
- GRID (NCT02361528)
- Testing
- Sargramostim: Leukine (Genzyme USA)
- Where
- 18 sites in France
- Volunteers
- 166 people
- Sponsor
- Hospices Civils de Lyon
Covid19
Is Bio-adrenomedullin (Bio-ADM) a Prognostic Factor in Patients With COVID-19 Treated in the ICU?
This is prospective, observational study using point of care test to determine bio-ADM whole blood concentrations and its predictive value in patients with COVID-19 treated in the ICU.
- Trial name
- NCT04813939
- Testing
- IB10 sphingotest® bio-ADM® apparatus (Sphingotec GmbH, Hennigsdorf, Germany)
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Warsaw
Sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness
Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid…
- Trial name
- NCT07507877
- Testing
- Infraclavicular axillary vein collapsibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Infection, Sepsis
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection
This study evaluates the association between plasmatic levels of Mid Regional Proadrenomedullin (MR-proADM) and the sublingual microcirculation in critical care patients admitted with infection, sepsis or septic shock.
- Conditions
- Infection, Sepsis, Septic Shock
- Trial name
- NCT03931967
- Testing
- MR-proADM
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Università Politecnica delle Marche
Neonatal Sepsis
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital
- Trial name
- NCT06113653
- Testing
- Prospective study
- Volunteers
- 50 people
- Sponsor
- Assiut University
Thrombelastography, Sepsis
Thromboelastometry in Assessment of Sepsis Coagulopathy
The purpose of this study is to analyze occurence of bleeding complications during invasive procedures in septic patients with normal tromboelastometry results despite prolonged standard coagulation tests results
- Trial name
- NCT02971111
- Volunteers
- 76 people
- Sponsor
- University Hospital, Motol
Necrotizing Enterocolitis, Sepsis
The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants
The purpose of this study is to compare the effectiveness of L. Reuteri with placebo in prevention of NEC in children, as according to my knowledge, there is limited work is done nationally and internationally.
- Trial name
- NEC (NCT04541771)
- Testing
- Lactobacillus Reuteri DSM 17938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Sepsis
Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults
Trial design: Randomised controlled, two-arm, parallel, clinical trial to assess the efficacy and safety of sequential daily procalcitonin assessments to guide de-escalation of empirical antibiotic therapy in adult patients with…
- Trial name
- PROCALBAN (NCT05955612)
- Testing
- Procalcitonin measurement
- Where
- Bangladesh
- Volunteers
- 532 people
- Sponsor
- University of Oxford
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Sepsis, Nutrition
Comparison of Short Peptide and Whole Protein Formula in the Early Enteral Nutrition of Patients With Sepsis
To explore the effects of early enteral nutrition with short peptide formula on energy metabolism and clinical outcomes in patients with sepsis based on blood samples, clinical database, full-spectrum metabolomics test and…
- Trial name
- NCT07038057
- Testing
- Short peptide enteral nutrition, Whole protein enteral nutrition
- Volunteers
- 80 people
- Sponsor
- Shanghai Zhongshan Hospital
Frailty, Septic Shock
Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.
The aim of the study is to demonstrate that "frail" patients, defined as having a CFS score greater than or equal to 5, and "severely" frail patients, defined as having a CFS score between [6-7] as defined by Bagshaw et al (14)…
- Trial name
- Woodstock (NCT05928767)
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Lens
Septic Shock, Multi Organ Failure
The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock
Sepsis is a major healthcare problem and leading cause of death in the pediatric population. Despite advances in supportive care of critically ill patients, sepsis remains an important cause of death worldwide in children.
- Trial name
- NCT05401695
- Testing
- HA330 hemoadsorption technique
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Low Gelsolin, Trauma
Ascending Single Dose Study of Rhu-pGelsolin in Patients With Decreased Gelsolin Levels
This study is designed to assess the pharmacokinetics and safety of an infusion of a single dose of recombinant plasma gelsolin (rhu-pGelsolin) when given to patients admitted to the Intensive Care Unit with documented low levels…
- Conditions
- Low Gelsolin, Trauma, Infection, Burns
- Trial name
- NCT00671307
- Testing
- rhu-pGelsolin
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Critical Biologics Corporation
CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic
Studies on Adsorption International Learning Initiative Global
Use of sorption technologies in patients undergoing maintenance hemodialysis with inflammatory syndrome and clinical manifestations of uremia
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic, Uremic; Toxemia, Inflammation Chronic
- Trial name
- SAILING (NCT07123909)
- Testing
- Patients will undergo a combined hemodialysis and hemosorption procedure. The study cartridge for hemosorption by Jafron HA130 contains the original adsorbing material.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Botkin Hospital
Shock, Systemic Inflammatory Response Syndrome
Safety and Efficacy of PHP in the Treatment of Shock Associated With Systemic Inflammatory Response Syndrome (SIRS)
To determine the safety and effectiveness of pyridoxylated hemoglobin polyoxyethylene conjugate (PHP) administered by continuous intravenous (IV) infusion in systemic inflammatory response syndrome (SIRS) patients with shock.
- Trial name
- NCT00021502
- Testing
- pyridoxalated hemoglobin polyoxyethylene conjugate (PHP)
- Volunteers
- 1,000 people
- Sponsor
- Apex Bioscience
Sepsis
Outcomes of Sepsis Patients in China (CHINA-SEP)
Sepsis poses a significant public health challenge in China. However, longitudinal real-world evidence on guideline adherence and patient outcomes remains scarce.
- Trial name
- CHINA-SEP (NCT07066553)
- Where
- China
- Volunteers
- 5,775 people
- Sponsor
- Southeast University, China
Sepsis Newborn, Malaria
Immune Dysfunction in Newborn Sepsis
The aim of the project is to study neonatal immune dysfunction associated to the risk of newborn sepsis in a malaria endemic area in Benin.
- Conditions
- Sepsis Newborn, Malaria, Immune Responses
- Trial name
- RECIPAL (NCT03780712)
- Testing
- Non applicable
- Volunteers
- 585 people
- Sponsor
- BioMérieux
Septic Shock
Comparison of ECMO Use and Conventional Treatment in Adults With Septic Shock
Although few cases reported successful treatment of septic shock using extracorporeal membrane oxygenation (ECMO) in adults, no studies compared ECMO to conventional treatment (without ECMO) as treatment for adults with septic…
- Trial name
- NCT01685112
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Probiotics
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients
Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose…
- Conditions
- Acute Kidney Injury, Probiotics, Sepsis
- Trial name
- NCT03877081
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Civil de Guadalajara
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
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