Clinical trials: Sepsis and Septic Shock
Sepsis, Septic Shock
DIAGNOSis of Infection in Emergency Department
Septic pathology is an extremely frequent reason for consultation in our emergency services, with an annual incidence of severe forms between 50 to 95 cases per 100,000 inhabitants and a constant increase estimated at 9% per…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Infection
- Trial name
- DIAGNOSED (NCT03708796)
- Testing
- SIRS, qSOFA, NEWS, RETTS scores evaluation
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences
Sepsis, Septic Shock
Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ
Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ). Purpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based "sepsis…
- Conditions
- Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- NCT07460024
- Testing
- Adapted Surviving Sepsis Campaign (SSC) Protocol, Standard Clinical Care
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Heart Failure, Myocarditis
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear.
- Conditions
- Heart Failure, Myocarditis, Sepsis, Septic Shock
- Trial name
- CONDUCT-ICU (NCT05633290)
- Testing
- CMR, hs-troponin, NT-pro BNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- NHS Greater Glasgow and Clyde
Fungal Infection
The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock
To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic…
- Trial name
- NCT05642624
- Testing
- Deoxycholic acid amphotericin B
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Septic Shock, Hypoperfusion
Early Methylene Blue in the Microhemodynamics of Septic Patients
The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or…
- Trial name
- NCT07264543
- Testing
- Methylene blue infusion
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Bacteremia, Bacteremia Sepsis
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
This project will evaluate the usefulness of Monocyte Distribution Width (MDW) for the diagnosis of blood culture positivity (BSI) in patients in the Emergency Department (ED) and reevaluate the usefulness of MDW in patients with…
- Conditions
- Bacteremia, Bacteremia Sepsis, Sepsis, Septic Shock
- Trial name
- NCT05296590
- Testing
- Monocyte Distribution Width (MDW) , observation
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Henry Ford Health System
Septic Shock
Transfusion-requirements in Septic Shock Trial
Patients with blood poisoning - sepsis - often receive blood transfusions in the intensive care unit. The evidence that blood transfusion leads to improved outcome is limited and the blood may be harmful to some of these…
- Trial name
- TRISS (NCT01485315)
- Testing
- SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion
- Where
- 32 sites in Denmark, Finland and 2 more
- Volunteers
- 1,005 people
- Sponsor
- Scandinavian Critical Care Trials Group
Severe Sepsis
AZD9773 Dose Escalation Study
This is a double-blind, placebo-controlled, multi-center, dose-escalation study to assess the safety, tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple ascending intravenous infusions of CytoFab (AZD9773)…
- Trial name
- NCT00615017
- Testing
- AZD9773 (CytoFab)
- Where
- 26 sites in United States
- Volunteers
- 70 people
- Sponsor
- AstraZeneca
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) as assessed by standard of care vasopressor dose reduction in pediatric patients with catecholamine-resistant hypotension…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Septic Shock
- Trial name
- NCT03623529
- Testing
- LJPC-501 (angiotensin II)
- Where
- 2 sites in Belgium, Lithuania
- Volunteers
- 100 people
- Sponsor
- La Jolla Pharmaceutical Company
Severe Sepsis, Septic Shock
Volume Replacement With Albumin in Severe Sepsis
BACKGROUND The association between mortality and hypoalbuminemia has been observed in several diseases. Nonetheless, the efficacy of albumin on survival in critically ill patients is controversial.
- Trial name
- ALBIOS (NCT00707122)
- Testing
- Albumin and Crystalloids, Crystalloids
- Where
- Italy
- Volunteers
- 1,818 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Toxic Shock Syndrome, Vaccination; Sepsis
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- rTSST-1 (NCT02340338)
- Testing
- rTSST-1 Variant Candidate Vaccine
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Septic Shock
Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock
in this study the investigators aim to assess the role of using dexmedetomidine as sedative in septic shock patients in comparison with midazolam.
- Trial name
- RODIS (NCT03989609)
- Testing
- Dexmedetomidine Injection [Precedex], Midazolam
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Kasr El Aini Hospital
ARDS, Septic Shock
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation
to evaluate the effect of use of bronchoscopy in the course of sepsis, weaning from the ventilator, duration of ICU stays and mortality rate in septic patients with ARDS due to VAP.
- Trial name
- NCT04553367
- Testing
- Meropenem, bronchoscopy, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Healthy Volunteer Safety Study
AB103 Peptide Antagonist in Healthy Volunteers
The primary objective of this study is to establish the safety profile and maximum tolerated dose (MTD) of AB103 given as a single intravenous (IV) infusion in healthy volunteers.
- Trial name
- NCT01166984
- Testing
- AB103
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Atox Bio Ltd
Septic Shock
Rapid Administration of Carnitine in sEpsis
Prior work has shown that exogenous L-carnitine administration enhances glucose and lactate oxidation, attenuates fatty acid toxicity, and improves endothelial-smooth muscle coupling and cardiac mechanical efficiency.
- Trial name
- RACE (NCT01665092)
- Testing
- Levo-Carnitine
- Where
- 14 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Mississippi Medical Center
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether…
- Trial name
- PRoMPT BOLUS (NCT04102371)
- Testing
- Lactated Ringer, Normal Saline, Plasma-lyte
- Where
- 22 sites in United States
- Volunteers
- 9,041 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock, Left Ventricular Systolic Dysfunction
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
Septic shock is a major cause of death in intensive care. Septic shock is often dominated by profound changes in organ functions, of which cardiac failure is one of the most severe.
- Conditions
- Septic Shock, Left Ventricular Systolic Dysfunction, Left Ventricular Diastolic Dysfunction
- Trial name
- Septic Heart (NCT01747187)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Septic Shock
Survey of Non-resuscitation Fluids in Septic Shock
The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.
- Trial name
- SURF (NCT03438097)
- Where
- 9 sites in Canada, Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Sepsis
Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients
In 2005, the Food and Drug Administration (FDA) approved procalcitonin in conjunction with other laboratory markers to aid in the risk assessment of critically ill patients with severe infection (sepsis).
- Trial name
- PCT (NCT01362920)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic