Clinical trials: Septic
Healthy, Lung Disease
Effects of Endotoxin in Normal Human Volunteers
Bacterial infections can progress to a life-threatening illness called septic shock, characterized by low blood pressure and vital organ damage.
- Conditions
- Healthy, Lung Disease, Sepsis, Septic Shock
- Trial name
- NCT00001303
- Testing
- Reference Endotoxin, Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Severe Sepsis, Septic Shock
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients.
- Trial name
- NCT00541827
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sepsis, Systemic Inflammatory Response Syndrome
Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics
This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2 using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and pharmacodynamics in ASA I-III surgical patients.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome, Septic Shock
- Trial name
- ROCSEPSIS (NCT02399397)
- Testing
- Serial blood sampling, Train of four monitoring, Blood testing for liver and renal function
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Severe Sepsis, Septic Shock
Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa
The purpose of this study is to compare the tendency of plasma concentration and clearance of procalcitonin in the first 24 and 48 hours of management of patients with severe sepsis and septic shock with another marker of early…
- Trial name
- NCT01841190
- Where
- 2 sites in Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Domingos
Sepsis
Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock
In this prospective, single-center,randomized,controlled,single-blind clinical trial,Patients will be randomly assigned to receive granisetron or placebo for 4 days or until leaving the ICU(death or transfer from ICU to general…
- Trial name
- GRANTISS (NCT03924518)
- Testing
- Granisetron Hydrochloride
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Zhujiang Hospital
Septic Shock, Acute Renal Failure
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal…
- Trial name
- NCT00816790
- Testing
- Piperacillin/Tazobactam
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Fraser Health
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Sepsis, Infection
BLOOM: Pragmatic Feasibility Trial
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method.
- Trial name
- NCT07287332
- Testing
- Up-front individualized dosing algorithm, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Toxic Shock Syndrome
Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study
Staphylococcus aureus and Streptococcus pyogenes produce many virulence factors. Some of them are responsible for severe infections in humans. Superantigen toxins synthesized by S. aureus or by S.
- Trial name
- IVIG (NCT02219165)
- Testing
- Intravenous human immunoglobulin, Albumin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Internal Jugular Vein, Inferior Vena Cava
Internal Jugular Vein and Inferior Vena Cava Collapsibility Indices as a Guidance of Fluid Responsiveness in Septic Shock Cancer Patients
This study aimed to compare between internal jugular vein and inferior vena cava collapsibility indices as a guidance of fluid responsiveness in septic shock cancer patients.
- Conditions
- Internal Jugular Vein, Inferior Vena Cava, Collapsibility Indices, Fluid Responsiveness
- Trial name
- NCT07879287
- Testing
- Ultrasonographic assessment of internal jugular vein (IJV) collapsibility, Ultrasonographic assessment of inferior vena cava (IVC) collapsibility
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Acute Kidney Injury, Septic Shock
RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock
Acute kidney injury (AKI) is a common complication in critically ill patients. Multiple studies have reported evidence that the main cause of ARF is sepsis, as part of the Multiple Organ Dysfunction Syndrome: up to 50% of septic…
- Trial name
- NCT04952714
- Testing
- Oxiris
- Where
- Colombia
- Volunteers
- 93 people
- Sponsor
- Clinica CES
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Sepsis, Microcirculation
Myocardial Contrast Echocardiography in Septic Patients
Myocardial microcirculatory alterations may be involved in the pathogenesis of acute cardiac dysfunction or septic cardiomyopathy in septic patients.
- Trial name
- NCT04397640
- Testing
- Sonovue
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Septic Shock
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
The purpose of this study is to assess the concordance of therapeutic changes proposed after an early hemodynamic evaluation (hemodynamic profile) in septic shock patients using jointly the transpulmonary thermodilution technique…
- Trial name
- HEMOSEPSIS (NCT01188993)
- Testing
- early septic shock
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Limoges
Sepsis, Perfusion Index
Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis
In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can…
- Conditions
- Sepsis, Perfusion Index, Vasopressor
- Trial name
- NCT06860438
- Testing
- Vasoconstrictor Agents
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sepsis-induced Cardiomyopathy, the Recovery Phase of Septic Shock
Recombinant Human Brain Natriuretic Peptide for the Recovery Stage of Septic Shock
As infection control improves and circulation stabilizes, treatment de-escalation of septic shock begins, accompanied by fluid redistribution from interstitial spaces to the vasculature, increasing cardiac volume load.
- Trial name
- rh-BNP-RSS (NCT06745206)
- Testing
- Lyophilized Recombinant Human Brain Natriuretic Peptide
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Septic Shock
A Prediction Model of 28-day Mortality in Septic Shock
This clinical study adopts the design of cohort research, selects the sepsis shock patients admitted to our hospital ICU as the research object, takes the 28-day mortality rate as the outcome index, collects the baseline data of…
- Trial name
- NCT04915625
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis
Endotoxin Adsorber Hemoperfusion and Microcirculation
Despite maintaining adequate mean arterial pressure and central venous oxygen saturation, the mortality is still high in severe sepsis and septic shock.
- Trial name
- NCT01756755
- Testing
- PMX-20R Hemoperfusion
- Where
- 3 sites in Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital