Clinical trials: Septic Acute Kidney Injury
Sepsis-associated AKI
Oxiris in Septic AKI
Sepsis is a leading cause of acute kidney injury (AKI) in critically ill patients, with sepsis-associated AKI accounting for approximately 50% of all AKI cases in the intensive care unit.
- Trial name
- NCT07641660
- Testing
- Oxiris, Standard CRRT
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Acute Kidney Injury
Algorithm for Oliguria in Septic Shock
Acute Kidney Injury (AKI) develops in 88% to 30% of critically ill patients admitted to an intensive care unit and is a strong predictor of mortality.Therefore any management strategy that prevents progression of renal risk to…
- Trial name
- AMOSS (NCT02338895)
- Testing
- Ultrasound
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Septic Shock
Severe Septic Shock Complications
Adults older than 18 years old, admitted to the ICU with a Severe Septic Shock, requiring Norepinephrine at more than 0.25mcg/kg/min, who have signed informed consent form, will be consecutively included, from december 2018 to…
- Trial name
- NCT03716895
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Septic Shock, Acute Kidney Injury
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Sepsis and septic shock are major causes of mortality in critically ill patients and are frequently associated with acute kidney injury requiring renal replacement therapy.
- Trial name
- NCT07569406
- Testing
- Oxiris filter, Standard Hemofilter
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Critically Ill, Acute Kidney Injury
Remote Ischemic Preconditioning in Septic Patients
Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis
- Trial name
- RIPC-ICU (NCT05830669)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Sepsis, Septic Shock
Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients
Investigators predict that the information that can be obtained in terms of renal functions before clinical development in sepsis patients can be valuable in terms of guiding treatment algorithms, planning renal replacement…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT05310812
- Testing
- Biochemical evaluation.
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Istanbul University
Burns, Hemofiltration
Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)
The purpose of this study is determine if High-Volume Hemofiltration in addition to 'contemporary' care will result in an improvement of select clinical outcomes when compared to 'contemporary' care alone in the treatment of…
- Conditions
- Burns, Hemofiltration, Kidney Failure, Acute, Shock, Septic
- Trial name
- RESCUE (NCT01213914)
- Testing
- An FDA approved continuous renal replacement device, Control Group
- Where
- 9 sites in United States
- Volunteers
- 37 people
- Sponsor
- American Burn Association
Acute Renal Failure
Open-Label Study To Evaluate the Safety and Efficacy of the Renal Assist Device In Patients With Acute Renal Failure
Although conventional hemodialysis removes waste products and corrects fluid imbalance, it does not replace critical absorptive, metabolic, endocrine, and immunologic functions performed by healthy renal tubule cells.
- Trial name
- NCT00511407
- Testing
- Renal tubule assist device
- Where
- 13 sites in United States
- Volunteers
- 58 people
- Sponsor
- RenaMed Biologics
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences
Acute Kidney Injury, Sepsis
MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI
In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period.
- Conditions
- Acute Kidney Injury, Sepsis, Critical Illness, Renal Resistive Index
- Trial name
- SEPTIC AKI (NCT07472452)
- Testing
- Renal Resistive Index (RRI) Doppler Ultrasound, Urinary TIMP-2 and IGFBP-7 biomarkers
- Volunteers
- 130 people
- Sponsor
- Ankara Etlik City Hospital
Acute Kidney Injury, Sepsis
Doppler Ultrasound for Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients
Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent Acute Kidney Injury (AKI) using the color Doppler Ultrasound derived Renal Resistive Index (RI) and…
- Conditions
- Acute Kidney Injury, Sepsis, Renal Resistive Index
- Trial name
- NCT03597074
- Testing
- color Doppler Ultrasound derived RI and semi-quantitative evaluation of intra-renal vascularization
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Aristotle University Of Thessaloniki
Acute Kidney Injury Due to Sepsis
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock
The goal of this clinical trial is to evaluate the efficacy of a hemodynamic resuscitation protocol guided by the Venous Return Gradient (Pmsf - CVP), measured via the non-invasive arm cuff technique, in reducing the incidence of…
- Trial name
- NCT07481097
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury Due to Sepsis
N/LP Ratio as Predictor of Mortality in Septic AKI Patients
To evaluate the role of Neutrophils to lymphocytes and platelets ratio (N/LP ratio) as a biomarkers for mortality in septic -AKI
- Trial name
- NCT05559086
- Volunteers
- 200 people
- Sponsor
- Mahmoud Kamel Mohamed Abd elhaq
Severe Sepsis, Shock, Septic
L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury
The primary objective of this study is to compare 28 day mortality rates between septic shock patients with acute renal insufficiency treated via L-Carnitine (as an adjunct therapy) versus a similar group of patients not…
- Conditions
- Severe Sepsis, Shock, Septic, Acute Kidney Injury
- Trial name
- CarniSave (NCT02664753)
- Testing
- 56 days of weight-adjusted L-Carnitine treatment
- Where
- 11 sites in France
- Volunteers
- 254 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Lithium Clearance in Patients With High Risk of Acute Kidney Injury
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
- Trial name
- NCT05648435
- Testing
- Lithium measures
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India