Clinical trials: Septic Shock, app or software or digital or wearable or device or sensor, open to volunteers
- Condition Septic Shock
- Drug or intervention app OR software OR digital OR wearable OR device OR sensor
- Status Open to volunteers
Sepsis and Septic Shock
Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using…
- Trial name
- NCT07516236
- Testing
- Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Sepsis
Extracorporeal cfDNA Removal in Septic Shock Patients With Elevated DNA Levels
Sepsis continues to be a major global health concern, characterized by high morbidity and mortality rates. As a clinical syndrome characterized by a dysregulated systemic response to infection, its progression toward…
- Trial name
- NCT07657767
- Testing
- Extracorporeal therapy, Extracorporeal elimination of cfDNA using "Nucleocore"
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Sergey Savko
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Septic Shock
Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock
Randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of therapeutic plasma exchange in patients with early septic shock.
- Trial name
- EXCHANGE-2 (NCT05726825)
- Testing
- Therapeutic Plasma Exchange (TPE)
- Where
- 25 sites in Austria, Germany and 1 more
- Volunteers
- 274 people
- Sponsor
- Hannover Medical School
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
Septic Shock
Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients
The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the…
- Trial name
- NCT07321405
- Testing
- echocardiogram, Electrical cardiometry
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Bloodstream Infection, Sepsis
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
The objective of the study is to determine the efficacy of the Microbio InfectID-BSI qPCR kit in a clinical laboratory environment using patient whole blood for pathogen detection and identification versus standard of care…
- Conditions
- Bloodstream Infection, Sepsis, Septic Shock
- Trial name
- IID-BSIqPCR (NCT06531031)
- Testing
- InfectID-BSI (Bloodstream Infection) qPCR Assay
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Microbio Co Ltd
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis
Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane
Sepsis remains a global scourge. Before the SARS-CoV-2 pandemic, the World Health Organization estimated approximately 49 million cases annually, resulting in 11 million deaths.
- Trial name
- PLAQSIRIS (NCT06440317)
- Testing
- Hemofiltration membranes (the oXiris membrane® and the HF1400® membrane)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Septic Shock
Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is the most expensive healthcare condition to treat in United States and has a mortality rate of nearly 30%.
- Trial name
- NERINASEPSIS (NCT03992378)
- Testing
- Low Level Transcutaneous Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Sepsis, Severe Sepsis With Septic Shock
Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients
Blood lactate level is closely associated with the prognosis of patients with sepsis and septic shock. Clinical guidelines explicitly recommend blood lactate monitoring in septic patients and lactate-guided fluid resuscitation…
- Conditions
- Sepsis, Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
- Trial name
- NCT07716371
- Testing
- High-Concentration Sweat Lactate Wearable Monitoring Device, Commercial Sweat Collection Device (HELA)
- Volunteers
- 86 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Septic Shock
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation. A Pilot Multicenter Randomized Controlled Trial. The goal of this clinical trial is the estimation of the efficacy and safety of hemoadsorption…
- Trial name
- HAdSS (NCT07661303)
- Testing
- Efferon LPS, Toramyxin PMX 20R, Jafron HA 330
- Where
- 7 sites in Russia
- Volunteers
- 76 people
- Sponsor
- Moscow Multidisciplinary Clinical Center "Kommunarka"
Infection in ICU, Sepsis
Early Optimization of Ceftazidime Regimen in Critical Care
Hospital-acquired infections, most of which are caused by Gram-negative bacteria, are common in intensive care units and have a major impact on patient prognosis.
- Conditions
- Infection in ICU, Sepsis, Septic Shock, Pseudomonas Aeruginosa Infection
- Trial name
- FORTOPTIM_1 (NCT07085624)
- Testing
- ceftazidime, plasma ceftazidime dosage
- Where
- 8 sites in France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Septic Shock
Effects of Hemoadsorption on Vascular Integrity in Septic Shock
This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock.
- Trial name
- ADSORP-VIP (NCT07711197)
- Testing
- CytoSorb hemoadsorption, Standard Medical Therapy (SMT)
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Sepsis, Septic Shock
IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis
Pediatric population who suffered from sepsis due to perforated viscus will receive fluid resuscitation guided by either central venous pressure or guided by IVC collapsibility index.
- Conditions
- Sepsis, Septic Shock, Perforated Viscus, Hospitalism in Children
- Trial name
- NCT06833333
- Testing
- Central venous catheter, IVC collapsibility index
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Septic Shock, Abdominal Sepsis
OXiris for Abdominal SEptic Shock (OASES Study)
This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal…
- Conditions
- Septic Shock, Abdominal Sepsis, Multi Organ Failure, Blood Purification
- Trial name
- OASES (NCT06504316)
- Testing
- CRRT filter
- Where
- China
- Volunteers
- 192 people
- Sponsor
- RenJi Hospital
Septic Shock, Multi Organ Failure
Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)
The goal of this clinical trial is to evaluate if a blood purification treatment called "Oxiris" works to help adults with septic shock.
- Trial name
- EXPOLRE (NCT07334327)
- Testing
- Oxiris Filter (Blood Purification Device)
- Volunteers
- 62 people
- Sponsor
- Pusan National University Yangsan Hospital
Acute Kidney Injury Due to Sepsis
Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy With oXiris Membrane
The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes.
- Trial name
- HISTORIX (NCT05575024)
- Testing
- oXiris membrane, Polysulfone membrane
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Seoul National University Hospital