Clinical trials: Septic Shock
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sepsis, Severe Sepsis and Septic Shock
Evaluation of CPD MNV as an Aid in the Diagnosis and Risk Assessment of Sepsis (Protocol # Sepsis 1-14)
The investigators hypothesize that CPD parameters will provide improved prediction of sepsis compared to currently employed laboratory parameters.
- Trial name
- Beckman (NCT02232750)
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Septic Shock
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume induced by a rapid fluid…
- Trial name
- AUSTRALIS (NCT04693923)
- Testing
- Fluid challenge
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Septic Shock, Tachycardia
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility
Several data emphasize the relation between tachycardia (>90/min) and high mortality during septic shock. The investigators previously demonstrated the high mortality associated with hypercontractility, tachycardia and the…
- Conditions
- Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker
- Trial name
- HyperBetashock (NCT04748796)
- Testing
- echocardiography, Landiolol
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis, Septic Shock
Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury
Populations at high risk of Sepsis-Associated Acute Kidney Injury (SA-AKI) have been identified. Sources of sepsis, in particular, bloodstream infection, abdominal and genitourinary sepsis, and infective endocarditis, are…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- RRIBIOSAKI (NCT03799159)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Islam Elsayed Mohamed Ahmed
Sepsis
Prognostic Value of Right Ventricular-pulmonary Arterial Coupling Assessed by Echocardiography in Septic Patients
Sepsis and septic shock are common clinical conditions, representing a significant healthcare challenge due to their high mortality rates and increasing incidence.
- Trial name
- NCT06887140
- Testing
- Echocardiography
- Where
- Vietnam
- Volunteers
- 215 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Sepsis, Severe Sepsis
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure
- Trial name
- NCT01315782
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock
Methylene Blue for the Treatment of Septic Shock
The purpose of this study is to evaluate the efficacy and safety of methylene blue among adult patients with septic shock.
- Trial name
- NCT06532240
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Northern Jiangsu People's Hospital
Sepsis, Septic Shock
Fluid Resuscitation in Septic Shock Patients With BMI Elevation
To explore the safety and feasibility of alternative fluid resuscitation strategies in obese patients with septic shock.
- Conditions
- Sepsis, Septic Shock, Obesity
- Trial name
- FRISSBE (NCT04759989)
- Testing
- Actual Body Weight Dosing, Adjusted Body Weight Dosing, Ideal Body Weight Dosing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Septic Shock
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients
Although arginine vasopressin has been used as an additional drug in refractory shock in worldwide clinical practice, there are no prospective studies using it as a first choice therapy in patients with cancer and septic shock.
- Trial name
- VANCS II (NCT01718613)
- Testing
- Vasopressin, Norepinephrine
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Sepsis, Septic Shock
Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis
Cardiogenic shock is a condition of low cardiac output that represents the end of a progressive deterioration of cardiac function.
- Conditions
- Sepsis, Septic Shock, Cardiogenic Shock
- Trial name
- GLASSES-1 (NCT04141410)
- Testing
- Levosimendan, Echocardiography
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Azienda USL Toscana Centro
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Shock, Septic, Pituitary Dysfunction
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis.
- Conditions
- Shock, Septic, Pituitary Dysfunction, Hypopituitarism
- Trial name
- NCT05990491
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Septic Shock
PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock
This study evaluates PK/PD of an extended-infusion protocol of meropenem, piperacillin-tazobactam and cefepime, in the early phase of septic shock.
- Trial name
- PAACS (NCT02820987)
- Testing
- MEROPENEM, PIPERACILLIN-TAZOBACTAM, CEFEPIME
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Septic Shock, Peritonitis
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis (EPI Study)
The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.
- Trial name
- NCT02805049
- Testing
- Echinocandins
- Where
- 2 sites in Australia, France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Septic Shock
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
This study has been approved as a nested substudy of a multicenter trial (CORVICTES, Clinicaltrials.gov Identifier: NCT03592693).
- Trial name
- CORVICTES-ΥΜ (NCT03649633)
- Testing
- Stress-dose Hydrocortisone plus Vitamin C
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital
Clarify different causes of sepsis in patients admitted to ICU . as well asCompare causes and outcomes of sepsis between diabetics versus non diabetics .
- Trial name
- NCT04015752
- Testing
- culture from infected site
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis, Septic Shock
Multicenter Symphony™ IL-6 Monitoring Sepsis ED Pilot Study
The primary objective of this study is to establish an IL-6 concentration cutoff that predicts sepsis or septic shock (according to the Third International Consensus Definitions (Sepsis-3 criteria)) in patients who are admitted…
- Trial name
- SYMON III (NCT07425587)
- Where
- 5 sites in United States
- Volunteers
- 450 people
- Sponsor
- Bluejay Diagnostics, Inc.