Clinical trials: Septicemic Shock
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock
The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock
This study will include patients requiring high dose of norepinephrine (NA) to maintain blood pressure after fluid resuscitation.
- Trial name
- NCT04970602
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xiangya Hospital of Central South University
Severe Sepsis
Hydrocortisone for Prevention of Septic Shock
Severe sepsis is a disease with a high mortality. Development of shock is a most serious complication and increases the risk of death considerably.
- Trial name
- HYPRESS (NCT00670254)
- Testing
- Hydrocortisone
- Where
- 30 sites in Germany
- Volunteers
- 380 people
- Sponsor
- Charite University, Berlin, Germany
Septic Shock, Sepsis
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
- Trial name
- ViCiS (NCT03835286)
- Testing
- Vitamin C
- Where
- Mexico
- Sponsor
- Hospital Español de Mexico
Septic Shock
Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients
We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.
- Trial name
- ClMLsepsis (NCT03700346)
- Testing
- microdialysis
- Where
- 2 sites in Tunisia
- Volunteers
- 73 people
- Sponsor
- Military Hospital of Tunis
Sepsis, Septic Shock
The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis
The primary aim of this study is to assess the effects of adjunctive therapy with Interferon (IFN)-gamma on immune function in patients with septic shock in a placebo-controlled manner.
- Trial name
- NCT01649921
- Testing
- Interferon-gamma, Recombinant, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Radboud University Medical Center
Necrotizing Soft Tissue Infection, Necrotizing Fascitis
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fascitis, Gas Gangrene, Fournier Gangrene
- Trial name
- ProTreat (NCT03147352)
- Testing
- Hyperbaric oxygen therapy
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Ole Hyldegaard
Sepsis, Septic Shock
Adjuvant Use of Neostigmine in Sepsis and Septic Shock.
The inflammatory response represents an important, central component of sepsis. Therefore, it is believed that blunting inflammation will decrease mortality.
- Trial name
- NCT04130230
- Testing
- Neostigmine, Standard therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Sepsis
Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome
Nitric oxide (NO) plays a pivotal role in maintenance of normal vascular tone. However, in sepsis the excessive production of NO results in myocardial depression, vasoplegia, and cytotoxic effects, thus promoting shock and…
- Trial name
- MB-NO (NCT00159510)
- Testing
- Methylene blue, Nitric oxide, Methylene blue & nitric oxide
- Where
- Russia
- Volunteers
- 28 people
- Sponsor
- Northern State Medical University
Septic Shock, Compliance
Effects of Nursing Staff on Empiric Antibiotic in Septic Shock
A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016.
- Conditions
- Septic Shock, Compliance, Antibiotic, Nursing Caries
- Trial name
- NCT03085459
- Testing
- work Time
- Volunteers
- 214 people
- Sponsor
- Chun Pan
Neonatal Sepsis, Refractory Shock
Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm Neonate
A randomized, prospective study comparing methylene blue versus terlipressin in treatment of catecholamines resistant shock in preterm neonate
- Trial name
- NCT04110418
- Testing
- Methylene Blue
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Sepsis
ASpirin for Patients With SEPsis and SeptIc Shock
This Randomized, pragmatic, multicentric with blinding of patients and health professionals, intention-to-treat analysis has by primary endpoint to evaluate whether the aspirin use reduces the intensity of organic dysfunction…
- Trial name
- ASP-SEPSIS (NCT01784159)
- Testing
- Aspirin
- Where
- Brazil
- Volunteers
- 167 people
- Sponsor
- Federal University of São Paulo
Sepsis, Septic Shock
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
- Trial name
- VaCoSS (NCT00698048)
- Where
- Singapore
- Volunteers
- 136 people
- Sponsor
- Jan Hau Lee
Septic Shock, Peritonitis
Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™
Sepsis is a major cause of death in Intensive Care Units and therefore finding new therapies to improve survival rates and limit morbidity is a major goal.
- Trial name
- ECRO (NCT03426943)
- Testing
- Arterial blood sampling, Ultrafiltrate sampling, CVVH using oXiris™ filter
- Where
- 8 sites in France
- Volunteers
- 39 people
- Sponsor
- Hospices Civils de Lyon
Artificial Intelligence, Septic Shock
Artificial Intelligence for Sepsis Prediction in ICU
The development of sepsis prediction model in line with Chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect.
- Conditions
- Artificial Intelligence, Septic Shock, Intensive Care Unit Psychosis
- Trial name
- AICUSepsis (NCT04913181)
- Testing
- Artificial intelligence sepsis prediction model
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Septic Shock
Fluid Intolerance Signals as Safety Limits to Prevent Fluid-induced Harm During Septic Shock Resuscitation
The goal of this multicentric randomized controlled trial is to compare, in septic shock patients who require further fluid resuscitation, two strategies of administering fluids.
- Trial name
- NCT06568744
- Testing
- Intervention resuscitation, Standard of Care resuscitation
- Where
- 3 sites in Chile
- Volunteers
- 62 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Septic Shock
The Effect of Midazolam on Fluid Responsiveness in Septic Patients
Fluid resuscitation remains the foundation for septic treatment.The evaluation of fluid responsiveness has significance in volume resuscitation for septic shock patients.
- Trial name
- NCT02050893
- Testing
- sedatives(Midazolam and Propofol)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Septic Shock, Severe Sepsis
Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Severe sepsis/septic shock is a serious condition associated with high mortality rate. Hydrocortisone has been recommended as a useful treatment to decrease mortality in hemodynamically unstable septic shock patients, not…
- Conditions
- Septic Shock, Severe Sepsis, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT01284452
- Testing
- Hydrocortisone
- Where
- Thailand
- Volunteers
- 197 people
- Sponsor
- Mahidol University
Cytomegalovirus Infection
Immune Response and Cytomegalovirus in Intensive Care Unit (ICU) Patients
This prospective study evaluate the immune status of patients admitted in ICU.CMV remains dormant in the body, but in people with immune deficiency, CMV could reactivate and cause life-threatening pneumonia.
- Trial name
- 2006/25 (NCT00699868)
- Testing
- Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markings
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
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