Clinical trials: Septicemic Shock
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Septic Shock
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
Surgical trauma elicits an immune response aiming to initiate healing and remove debris and damaged tissue locally at the wound site (1).
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Post-Op Complication
- Trial name
- NCT04117568
- Testing
- Blood sampling
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Göteborg University
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Septic Shock
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension.
- Trial name
- CLOVERS (NCT03434028)
- Testing
- Early Vasopressors, Early Fluids
- Where
- 50 sites in United States
- Volunteers
- 1,563 people
- Sponsor
- Massachusetts General Hospital
Septic Shock
L-Carnitine Administration in Early Sepsis
Sepsis is a severe and overwhelming response to an infection in the body. Over 750,000 patients in the United States develop sepsis every year.
- Trial name
- NCT01193777
- Testing
- L-Carnitine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Wake Forest University Health Sciences
Septic Shock
Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration
The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient.
- Trial name
- ECHO-VEVA (NCT07438301)
- Testing
- Echocardiogram
- Where
- Thailand
- Volunteers
- 180 people
- Sponsor
- Mahidol University
Severe Sepsis, Septic Shock
Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients.
IgM-enriched immunoglobulins (IgGAM; Pentaglobin ® ) are new therapy for sepsis and septic shock since they support immune system especially in case of " immunoparalysis" .
- Trial name
- NCT02655133
- Testing
- Pentaglobin®, Physiologic solution
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università Politecnica delle Marche
Sepsis, Septic Shock
Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients
The mortality induced by infections in onco-hematological patients is abnormally high at the acute phase of septic shock. Consequently, it is important to detect the population with a high risk of short term mortality among…
- Conditions
- Sepsis, Septic Shock, Cancer
- Trial name
- PROTEOHSEPS (NCT00930085)
- Testing
- SELDI-TOF MS for plasmatic proteic profile
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Septic Shock
Angiotensin II for Septic Shock Treatment
This study aims to investigate the effect of angiotensin II on microcirculation and peripheral perfusion in patients with septic shock.
- Trial name
- NCT03302650
- Testing
- Angiotensin II, Normal saline, Norepinephrine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Septic Shock
Effects of Levosimendan on Microcirculation in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to: investigate the effects of a combination of levosimendan and inhaled nitric oxide on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00800306
- Testing
- Levosimendan, dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy
Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global…
- Trial name
- NCT01877798
- Testing
- volume resuscitation, vasoactive drug
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Shock, Septic
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo.
- Trial name
- ASTONISH (NCT04055909)
- Testing
- nangibotide low dose, nangibotide high dose
- Where
- 43 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- Inotrem
Liver Cirrhosis
Muscle Tissue Oxygenation in Patients With Decompensated Liver Cirrhosis
Patients with decompensated liver cirrhosis exhibit numerous hemodynamic and microvascular changes, i.e., low systemic blood pressure and peripheral vasodilatation.
- Trial name
- NCT00849641
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University of Regensburg
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Septic Shock
Blood Purification for the Treatment of Pathogen Associated Shock
This study is a multi-center, randomized controlled feasibility trial to evaluate the initial safety and efficacy of a novel extracorporeal blood purification (EBP) therapy in critically ill patients with pathogen associated…
- Trial name
- PURIFY-RCT (NCT05011656)
- Testing
- Seraph-100 + State of the Art Care, State of the Art Care
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- ExThera Medical Corporation
Sepsis, Severe
Early Administration of Norepinephrine in Sepsis
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs.
- Trial name
- EA-NE-TUN (NCT05836272)
- Testing
- Norepinephrine Bitartrate
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Tunis University
Critical Illness, Antibiotic Toxicity
Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients
Although alternative dosing strategies can improve antimicrobial exposure in critically ill patients, the high PK variability in this population means that some may still receive sub-optimal antibiotic exposure leading to…
- Conditions
- Critical Illness, Antibiotic Toxicity, Sepsis, Septic Shock
- Trial name
- DOSATB (NCT04530045)
- Testing
- dosage of concentration of piperacillin and cefepim
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Septic Shock
Phenylephrine Versus Norepinephrine in Septic Shock
Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in…
- Trial name
- NCT00481442
- Testing
- Phenylephrine
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
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