Clinical trials: Septicemic Shock
Septic Shock
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient
The study aims to evaluate the accuracy of fluid responsiveness assessment with non-invasive cardiometry compared to ultrasound guided inferior vena cava (IVC) collapsibility for management of critically ill septic patients with…
- Trial name
- NCT05310942
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Sepsis, Septic Shock
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments
In this clinical trial the effect of early administration of Vitamin C is investigated in patients admitted at the emergency department with sepsis or septic shock.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- c-easie (NCT04747795)
- Testing
- Vitamin C, Normal saline
- Where
- 8 sites in Belgium
- Volunteers
- 301 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Shock, Septic
Vitamin C, Hydrocortisone and Thiamine for Septic Shock
Prior data has shown that both corticosteroids and vitamin C reduce the activation of nuclear factor ƘB (NFƘB), thereby ultimately attenuating the systemic inflammatory response to sepsis/septic shock and augmenting the…
- Trial name
- CORVICTES (NCT03592693)
- Testing
- Combined Vitamin C and Stress-Dose Hydrocortisone
- Where
- 2 sites in Greece
- Volunteers
- 24 people
- Sponsor
- University of Athens
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Morality, Sepsis
Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock
The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.
- Conditions
- Morality, Sepsis, Septic Shock
- Trial name
- NCT05921825
- Testing
- Red cell distribution width, lactate albumin ratio measurement
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Shock; Septic, Critical Illness
Targeted Tissue Perfusion Versus Macrocirculatory-guided Standard Care in Patients With Septic Shock
Background: The recommended monitoring and target levels in septic shock (SSC Guidelines 2012) including mean arterial pressure (MAP) target are not based on robust clinical data.
- Trial name
- TARTARE-2S (NCT02579525)
- Testing
- Hemodynamical treatment TTP, Hemodynamical treatment MCG
- Where
- 2 sites in Finland, Switzerland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis
Persistence of a marked compensatory anti-inflammatory innate immune response after an insult is termed immunoparalysis. There is no biomarker available to determine the immune status of patient.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- SIRCSS (NCT02887274)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
SIRS, Cytokine Storm
Cytokine Hemoadsorption in ECMO Patients
Cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability.
- Conditions
- SIRS, Cytokine Storm, Cardiogenic Shock, Cardiac Arrest
- Trial name
- NCT04901338
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Severe Sepsis, Septic Shock
Methylene Blue in Severe Sepsis and Septic Shock
This study is to see whether the intravenous administration of methylene blue improves the outcome in severe sepsis and septic shock.
- Trial name
- NCT01797978
- Testing
- Intravenous methylene blue administration
- Where
- 3 sites in South Korea
- Volunteers
- 354 people
- Sponsor
- Seoul National University Hospital
Septic Shock, Fluid Responsiveness
Timing of Preload Responsiveness in Sepsis
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness).
- Trial name
- TIPRES (NCT05627817)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Septic Shock
Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock
The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis
- Trial name
- NCT02962700
- Testing
- muscle microdialysis
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Military Hospital of Tunis
Septic Shock
Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB
This is a double-blind, placebo-controlled, randomized, multicenter proof of concept and dose-finding phase II study using two doses of ADRECIZUMAB in patients with early septic shock and a bio-ADM plasma concentration at…
- Trial name
- AdrenOSS-2 (NCT03085758)
- Testing
- Adrecizumab
- Where
- 30 sites in Belgium, France and 2 more
- Volunteers
- 301 people
- Sponsor
- Adrenomed AG
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Septic Shock
Renal Resistive Index in Septic Shock Patients
Septic shock is a condition of acute circulatory failure and is defined as a process that requires the use of vasopressors to ensure adequate tissue perfusion when hypotension develops.
- Trial name
- NCT06214715
- Testing
- Philips ultrasonography system
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Severe Sepsis, Septic Shock
Procalcitonin Monitoring Sepsis Study
The purpose of this study is to investigate the relationship between a procalcitonin decrease over 72 hours and outcome in patients who have severe sepsis or septic shock.
- Trial name
- MOSES (NCT01523717)
- Where
- 13 sites in United States
- Volunteers
- 858 people
- Sponsor
- Brahms AG
Septic Shock, Anemia
TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock
Septic shock is a frequent complication associated with high mortality in patients with malignancies. The best transfusion strategy (restrictive or liberal) for the resuscitation of septic shock remains a controversial issue, in…
- Conditions
- Septic Shock, Anemia, Cancer
- Trial name
- TRANSPORT (NCT03837171)
- Testing
- Liberal Red blood cell transfusion, Restrictive Red blood cell transfusion
- Where
- 20 sites in France
- Volunteers
- 192 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors
The main goals of this study are to provide a cognitive, neurological, brain morphological, and serological profile of sepsis survivors in order to make long-term prognosis of recovery and estimate the need for rehabilitation…
- Trial name
- BonSEP (NCT02339649)
- Testing
- Blood Sample, Neurocognitive Assessment, Resting State EEG
- Where
- 2 sites in Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Septic Shock, Chronic Heart Failure
eMESH Struct. 2022-23
A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD)…
- Trial name
- eMESH (NCT05202938)
- Testing
- ultrasound cardiography, FDG PET scan, Palmitate PET scan
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
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