Clinical trials: Septicemic Shock
Septic Shock
A Prediction Model of 28-day Mortality in Septic Shock
This clinical study adopts the design of cohort research, selects the sepsis shock patients admitted to our hospital ICU as the research object, takes the 28-day mortality rate as the outcome index, collects the baseline data of…
- Trial name
- NCT04915625
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock, Peritonitis
Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis (EPI Study)
The main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.
- Trial name
- NCT02805049
- Testing
- Echinocandins
- Where
- 2 sites in Australia, France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis Syndromes
Exercise in Critically Ill Patients With Sepsis
This study will investigate whether early exercise in critically ill patients will decrease inflammatory markers, increase pro-inflammatory markers and prevent loss of muscle mass.
- Trial name
- NCT01364909
- Testing
- Exercise, Usual practice
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- The University of Queensland
Sepsis Septic Shock
Bedside vs. Standard Microbiological Blood Culture Diagnostics - BEMIDIA Study
With a completely bedside blood culture diagnostics system (BACTEC blood culture system in combination with the Accelerate ID/AST System) it is possible to optimize the initial antimicrobial therapy in patients with sepsis and…
- Trial name
- BEMIDIA (NCT03000049)
- Testing
- bedside blood culture
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Medicine Greifswald
Sepsis, Severe Sepsis
Implementation and Evaluations of Sepsis Watch
The purpose of this study is to study the implementation and impact of an early warning system to detect and treat sepsis in the emergency room.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03655626
- Testing
- Sepsis Watch
- Where
- United States
- Volunteers
- 32,003 people
- Sponsor
- Duke University
Septic Shock, Echocardiography Guided Fluid Management
Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
The goal of this study is to evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock.
- Trial name
- NCT07136532
- Testing
- echocardiography
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sepsis
Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.
This study aims to validate a simple and reproducible index of capillary leak (CLI) in septic shock, based on haemoglobin (Hb) variation induced by standardised fluid resuscitation.
- Trial name
- IFC-sepsis (NCT07733206)
- Testing
- TEST GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in septic shock patients., CONTROL GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in non-septic postoperative patients.
- Where
- Martinique
- Volunteers
- 100 people
- Sponsor
- University Hospital Center of Martinique
Septic Shock
Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock
The proposed study will evaluate the potential benefit of a tapered course of hydrocortisone compared to abrupt cessation in patients initiated on hydrocortisone for septic shock.
- Trial name
- NCT01150409
- Testing
- hydrocortisone, Normal Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Cleveland Clinic
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Patients in Septic Shock
The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)
Septic shock has a high mortality risk despite the availability of various treatments. Endotoxin, that is present in the cell walls of gram-negative bacteria, is a potent trigger of innate immunity.
- Trial name
- NCT01948778
- Testing
- oXiris™ filter, Toraymyxin Filter, Standard of Care
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Cardiomyopathies, Sepsis
Translational Approaches to Septic Cardiomyopathy
This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived…
- Conditions
- Cardiomyopathies, Sepsis, Septic Shock
- Trial name
- TASC01 (NCT03252613)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Brown
Sepsis, Severe Sepsis
Protocolized Care for Early Septic Shock
The ProCESS study is large, 5-year, multicenter study of alternative resuscitation strategies for septic shock. The study hypothesizes that there are "golden hours" in the initial management of septic shock where prompt…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- ProCESS (NCT00510835)
- Testing
- Early Goal Directed Therapy (EGDT), Protocolized Standard Care (PSC), Usual Care (UC)
- Where
- 31 sites in United States
- Volunteers
- 1,351 people
- Sponsor
- University of Pittsburgh
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock, Sepsis
Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM)
Sepsis is a common syndrome resulting from a dysregulated response to infection. The timing of antibiotic initiation is an important determinant of outcomes for patients presenting to the emergency department with sepsis.
- Trial name
- NCT03226366
- Testing
- Immediate evaluation by multidisciplinary team
- Where
- 4 sites in United States
- Volunteers
- 3,230 people
- Sponsor
- Intermountain Health Care, Inc.
Severe Sepsis, Septic Shock
Echo vs. EGDT in Severe Sepsis and Septic Shock
Echocardiography (cardiac ultrasound) is being used more often in the critical care setting for management of severe infection (septic shock).
- Trial name
- ECHO RCT (NCT02354742)
- Testing
- Echo guided fluid resuscitation, EGDT fluid resuscitation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Intermountain Health Care, Inc.
Severe Sepsis, Septic Shock
Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis
The overall purpose of the study is to determine whether either of the Improved Response Polymorphisms (IRPs) individually predicts a differential DrotAA treatment effect in patients with severe sepsis and high risk of death.
- Trial name
- NCT01486524
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 3,000 people
- Sponsor
- Sirius Genomics Inc.
Sepsis, Disseminated Intravascular Coagulation
Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation
The primary objective of this study is to estimate the efficacy of unfractionated heparin(UFH) on ICU mortality in severe sepsis with suspected DIC.The Second objective is to estimate the effect of UFH on 28-day mortality,and the…
- Trial name
- NCT02654561
- Testing
- Heparin Sodium, Saline
- Where
- 17 sites in China
- Volunteers
- 600 people
- Sponsor
- China Medical University, China
Sepsis, Septic Shock
Strong Albumin Solutions in Patients With Septic Shock
Sepsis is an increasingly recognised burden to healthcare systems worldwide. Intravenous fluid therapy is a common first-line intervention recommended by international guidelines.
- Conditions
- Sepsis, Septic Shock, Shock, Toxic
- Trial name
- SWIPE2 (NCT05208242)
- Testing
- hyperoncotic human albumin solution, Buffered crystalloid solutions
- Where
- 2 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- Manchester University NHS Foundation Trust
Right Heart Failure, Unspecified, Critical Illness
Echocardiographic Evaluation of RV Injury in the ICU
The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome.
- Conditions
- Right Heart Failure, Unspecified, Critical Illness, ARDS, Human, Septic Shock
- Trial name
- RECHOicu (NCT05525936)
- Testing
- Echocardiography and central venous pressure
- Volunteers
- 440 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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