Clinical trials: Septicemic Shock
Sepsis, Septic Shock
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
- Trial name
- VaCoSS (NCT00698048)
- Where
- Singapore
- Volunteers
- 136 people
- Sponsor
- Jan Hau Lee
Sepsis, Severe Sepsis
Clarithromycin as Immunomodulator for the Management of Sepsis
The herein protocol is based on the results of one former clinical trial conducted by our study group showing the considerable efficacy of intravenously administered clarithromycin as an adjuvant to antimicrobial chemotherapy for…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT01223690
- Testing
- Clarithromycin, Dextrose 5%
- Where
- 6 sites in Greece
- Volunteers
- 600 people
- Sponsor
- University of Athens
Sepsis, Sepsis and Septic Shock
Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.
Sepsis is a serious condition where the body's immune response to infection overreacts, leading to organ damage and death. Venous congestion, a buildup of blood in the veins, can occur in sepsis and contribute to organ injury.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis at Intensive Care Unit, Intensive Care Nurses
- Trial name
- VEXIVAN (NCT07406750)
- Testing
- Education in performing hemodynamic diagnostic ultrasound of venous congestion, Hemodynamic diagnostic ultrasound of venous congestion
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Shock, Septic, Pituitary Dysfunction
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis.
- Conditions
- Shock, Septic, Pituitary Dysfunction, Hypopituitarism
- Trial name
- NCT05990491
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Sepsis, Septic Shock
The Role of Dysfunctional HDL in Sepsis
To determine the role of dysfunctional high density lipoprotein (Dys-HDL) in predicting or mediating progression to chronic critical illness or morbid long-term outcomes in patients being treated for community-acquired or…
- Trial name
- NCT02934997
- Testing
- Observational study
- Volunteers
- 88 people
- Sponsor
- University of Florida
SIRS, Sepsis
Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)
In this study patients with 1. chronicle liver diseases primary biliary cirrhosis primary sclerosing cholangitis alcoholic liver cirrhosis hepatitis b or C Wilson's disease cryptogenic cirrhosis 2.
- Conditions
- SIRS, Sepsis, Liver Disease
- Trial name
- NCT01169168
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Acute Kidney Injury, Septic Shock
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown.
- Conditions
- Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality
- Trial name
- TOX-AKI (NCT03920982)
- Testing
- Determination of the blood concentration of indoxyl sulfate (IS)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hyperdynamic, Left Ventricular Ejection Fraction
Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock
The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
- Conditions
- Hyperdynamic, Left Ventricular Ejection Fraction, Mortality, Intensive Care Unit
- Trial name
- NCT06993948
- Testing
- Transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Ain Shams University
Heart Failure, Sepsis
Skeletal Muscle Oxygenation in Critically Ill
It is possible to measure skeletal muscle tissue oxygenation (StO2) using near infrared spectroscopy(NIRS). It is performed non invasively.
- Conditions
- Heart Failure, Sepsis, Septic Shock, Cardiogenic Shock
- Trial name
- NCT00384644
- Testing
- NiRS measurment of tissue oxygenation
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Septic Shock
Heart Rate Control With Esmolol in Septic Shock
The purpose of this study is investigate the effects on systemic hemodynamics and organ function of esmolol when used to maintain heart rate below a predefined threshold in patients with septic shock.
- Trial name
- NCT01231698
- Testing
- esmolol, control
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Andrea Morelli
Septic Shock, Sepsis
Sepsis in the ICU-II
Sepsis-induced cardiac dysfunction (SIMD) is a well-known phenomenon yet its diagnosis remains elusive with no accepted definition, or defining pathophysiological mechanism associated with this disease.
- Conditions
- Septic Shock, Sepsis, Cardiomyopathies, Organ Failure, Multiple
- Trial name
- NCT04695119
- Testing
- Exposure is septic shock (defined according to Sepsis-III) and standard treatment according to departmental protocols.
- Where
- 4 sites in France, Sweden
- Volunteers
- 379 people
- Sponsor
- Linkoeping University
Oxidative Stress, Septic Shock
Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Sepsis and septic shock are public health problems worldwide that represents an excessive cost for health systems. Despite the great technological and research advances, mortality can reach up to 80% in patients with multiple…
- Trial name
- NCT03557229
- Testing
- Melatonin 5 mg, Vitamin C 1 GM Oral Tablet, Vitamin E 400 UNT
- Where
- Mexico
- Volunteers
- 131 people
- Sponsor
- American British Cowdray Medical Center
Sepsis, Septic Shock
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis
This study seeks to elucidate the quantitative expression of G - protein receptor 43/free fatty acid (GPR43/FFA2) receptors in patients with the diagnosis of sepsis and specifically, its expression as it relates to the severity…
- Conditions
- Sepsis, Septic Shock, Multiple Organ Dysfunction, Intra-abdominal Sepsis
- Trial name
- GPR43Sepsis (NCT02699905)
- Testing
- phlebotomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Sepsis, Septic Shock
Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit
Infections due to extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a major public health concern, in particular in the intensive care unit (ICU), due to the increase in their incidence.
- Trial name
- PITAGORE (NCT05565222)
- Testing
- Piperacillin/tazobactam or temocillin, Meropenem
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
The Diagnostic and Prognostic Value of Presepsin in Sepsis
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or…
- Trial name
- NCT06180265
- Testing
- presepsin, procalciton, endotoxin
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Foggia
Septic Shock
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock in Angers University Hospital
the purpose of this study is to assess the effect of norepinephrine and fluid expansion on capillary refill time during septic shock.
- Trial name
- NOVECAR-A (NCT05325957)
- Where
- France
- Sponsor
- University Hospital, Angers
Septic Shock, Severe Sepsis
GM-CSF to Decrease ICU Acquired Infections
The concept of acquired immunodeficiency after a first severe infection in the ICU is widely described in the literature. There is a dual risk: increased mortality and increased secondary infections.
- Trial name
- GRID (NCT02361528)
- Testing
- Sargramostim: Leukine (Genzyme USA)
- Where
- 18 sites in France
- Volunteers
- 166 people
- Sponsor
- Hospices Civils de Lyon
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