Clinical trials: Septicemic Shock
Terlipressin, Septic Shock
The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients
Terlipressin becomes a vasopressin for septic shock. But some studies found it may lead to severe intesitnal complications such as intestinal ischemia.
- Trial name
- NCT02306239
- Testing
- Terlipressin, Norepinephrine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Liu ZiMeng
Burns, Hemofiltration
Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)
The purpose of this study is determine if High-Volume Hemofiltration in addition to 'contemporary' care will result in an improvement of select clinical outcomes when compared to 'contemporary' care alone in the treatment of…
- Conditions
- Burns, Hemofiltration, Kidney Failure, Acute, Shock, Septic
- Trial name
- RESCUE (NCT01213914)
- Testing
- An FDA approved continuous renal replacement device, Control Group
- Where
- 9 sites in United States
- Volunteers
- 37 people
- Sponsor
- American Burn Association
Heading
Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?
Patients with septic shock in the intensive care unit have an elevated risk of developing acute kidney injury (AKI).
- Trial name
- AKI-CHECK (NCT02812784)
- Testing
- Nephrocheck TM
- Where
- 11 sites in France
- Volunteers
- 184 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Diastolic Dysfunction, Septic Shock
Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants
Sepsis is a life-threatening infection with increasing incidence, and its spectrum of disease can involve cardiac dysfunction, which further adds to mortality.
- Conditions
- Diastolic Dysfunction, Septic Shock, Cardiomyopathies
- Trial name
- SepticHeartG (NCT05552521)
- Testing
- Echocardiography
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Hospital Garcia de Orta
Septic Shock
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
The purpose of this study is to assess the concordance of therapeutic changes proposed after an early hemodynamic evaluation (hemodynamic profile) in septic shock patients using jointly the transpulmonary thermodilution technique…
- Trial name
- HEMOSEPSIS (NCT01188993)
- Testing
- early septic shock
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Limoges
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Septic Shock, Thrombocytopenia
Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children
The purpose of this study is to learn how blood clotting substances respond in children with septic shock, low platelet counts, and multiple organ failure (MOF) treated at different institutions.
- Conditions
- Septic Shock, Thrombocytopenia, Multiple Organ Failure
- Trial name
- TAMOF (NCT00118664)
- Where
- 12 sites in United States
- Volunteers
- 86 people
- Sponsor
- Children's Healthcare of Atlanta
Sepsis, Septic Shock
Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients
The mortality induced by infections in onco-hematological patients is abnormally high at the acute phase of septic shock. Consequently, it is important to detect the population with a high risk of short term mortality among…
- Conditions
- Sepsis, Septic Shock, Cancer
- Trial name
- PROTEOHSEPS (NCT00930085)
- Testing
- SELDI-TOF MS for plasmatic proteic profile
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Septic Shock, Endotoxemia
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
- Trial name
- TIGRIS (NCT03901807)
- Testing
- Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
- Where
- 20 sites in United States
- Volunteers
- 157 people
- Sponsor
- Spectral Diagnostics (US) Inc.
Sepsis, Septic Shock
Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death
The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in…
- Conditions
- Sepsis, Septic Shock, Endothelial Dysfunction
- Trial name
- ASGARD (NCT03847493)
- Testing
- Endothelial Glycocalyx
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Severe Sepsis, Septic Shock
Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients.
IgM-enriched immunoglobulins (IgGAM; Pentaglobin ® ) are new therapy for sepsis and septic shock since they support immune system especially in case of " immunoparalysis" .
- Trial name
- NCT02655133
- Testing
- Pentaglobin®, Physiologic solution
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock, Abdominal Sepsis
OXiris for Abdominal SEptic Shock (OASES Study)
This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal…
- Conditions
- Septic Shock, Abdominal Sepsis, Multi Organ Failure, Blood Purification
- Trial name
- OASES (NCT06504316)
- Testing
- CRRT filter
- Where
- China
- Volunteers
- 192 people
- Sponsor
- RenJi Hospital
Septic Shock, Hypotension
Esmolol to Treat the Hemodynamic Effects of Septic Shock
The main purpose of this study is to determine the effects of controlling the heart rate of patients with septic shock using an intravenous medication called esmolol.
- Conditions
- Septic Shock, Hypotension, Tachycardia
- Trial name
- NCT02369900
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Comparison Between Using Cardiometry and IVC Collapsibility
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Septic shock, a severe form of sepsis, is characterized by persistent hypotension and cellular/metabolic…
- Trial name
- NCT07411469
- Testing
- Cardiometry
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Severe Sepsis
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up
Subjects previously enrolled / randomized in the ReActIF-ICE (Recovery from acute immune failure in septic shock by immune cell extracorporeal terapy - immune competence enhancement) study received either standard sepsis…
- Trial name
- ReActIF- LTO (NCT06143137)
- Where
- 2 sites in Germany
- Volunteers
- 142 people
- Sponsor
- Artcline GmbH
Sepsis, Severe, Sepsis
Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock
The sublingual microcirculation is impaired in sepsis and septic shock. Sidestream dark field imaging technology has been developed into a clinical tool to help the clinician assess the microcirculation at the bedside.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock
- Trial name
- NCT05357339
- Testing
- 20% Albumin, Crystalloid
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- Rachael Cusack
Sepsis, Septic Shock
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Introduction: Timely and accurate antibiotic administration in emergency department (ED) patients with sepsis or septic shock is vital, given mortality rates of 20% and over 40%, respectively.
- Trial name
- NCT07167173
- Volunteers
- 10,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Septic Shock
Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock
Norepinephrine (NE) is a potent vasopressor used in septic shock to reverse hypotension. Early infusion of NE was associated with a favorable clinical outcome in a large cohort of patients .
- Trial name
- NCT02750683
- Volunteers
- 38 people
- Sponsor
- Hopital Antoine Beclere
Sepsis, Septic Shock
Ionized Calcium as a Severity Marker in Septic Shock Patients
Sepsis is a serious condition where the body has an extreme, dysregulated response to an infection, often leading to life-threatening organ dysfunction.
- Conditions
- Sepsis, Septic Shock, Hypocalcemia
- Trial name
- NCT07812051
- Volunteers
- 160 people
- Sponsor
- Assiut University
Sepsis, Septic Shock
Rotational Thromboelastometry Versus DIC Score in Sepsis
Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC).
- Trial name
- RODSS (NCT04610853)
- Testing
- rotational thromboelastometry
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
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