Clinical trials: Septicemic Shock
Severe Sepsis, Septic Shock
Prognostic Evaluation Of Severe Sepsis And Septic Shock. Procalcitonin Versus Delta Sofa
The purpose of this study is to compare the tendency of plasma concentration and clearance of procalcitonin in the first 24 and 48 hours of management of patients with severe sepsis and septic shock with another marker of early…
- Trial name
- NCT01841190
- Where
- 2 sites in Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Domingos
Septic Shock
Phenylephrine in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to compare: the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic…
- Trial name
- NCT00639015
- Testing
- Phenylephrine, Norepinephrine
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Supplemental Thiamine in Septic Shock: A Before-after Study
This controlled before-and-after study analyse the impact of thiamine supplementation on outcomes of patients with septic shock treated according to the surviving sepsis campaign 2021 guidelines
- Trial name
- NCT05840718
- Testing
- Thiamin
- Where
- 2 sites in Brazil
- Volunteers
- 73 people
- Sponsor
- Hospital Sao Domingos
Septic Shock
The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock
Fluid challenge is often carried out in septic shock patients. Its responsiveness usually requires invasive monitoring. The pulmonary artery catheter(PAC) is the most effective means of monitoring.To use non-invasive methods is…
- Trial name
- NCT03661268
- Testing
- fluid chanllenge
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chengdu Fifth People's Hospital
Sepsis, Septic Shock
Evolution of Muscle Function, Breathlessness and Quality of Life Following Intra or Extra-Abdominal Sepsis in ICU Patients
Sepsis is organ dysfunction secondary to an inappropriate host response to infection. In the most severe cases, circulatory failure necessitating the introduction of vasopressor therapy is called septic shock.
- Trial name
- EMBLemAticS (NCT06010186)
- Testing
- Ultrasound measurement of the diaphragm and intercostals
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Septic Shock
Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring cardiac index by thermodilution.
- Trial name
- MICAP (NCT07628023)
- Testing
- Swan-Ganz
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Examination of ADMA Serum Level and DDAH II
Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value.
- Trial name
- ADSeS (NCT01632059)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Septic Shock
Ratio of ''Central Venous-to-Arterial Co2 Gap'' to ''Arterial-to-Central Venous O2 Content Gap'' in Septic Shock
The high ratio of "central venous to arterial carbon dioxide" to "arterial to central venous oxygen content " is associated with elevated lactate in patients with septic shock.
- Trial name
- NCT04425161
- Testing
- Fluid challenge (0.9 % NaCl)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Sepsis
Immunomodulatory Properties of Ketamine in Sepsis
The aim of the study is to assess the effect of short-term infusion of ketamine at analgesic dosage on the immune response, morbidity and mortality among patients suffering from septic shock.
- Trial name
- NCT01089361
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Beth Israel Deaconess Medical Center
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) as assessed by standard of care vasopressor dose reduction in pediatric patients with catecholamine-resistant hypotension…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Septic Shock
- Trial name
- NCT03623529
- Testing
- LJPC-501 (angiotensin II)
- Where
- 2 sites in Belgium, Lithuania
- Volunteers
- 100 people
- Sponsor
- La Jolla Pharmaceutical Company
Hypophosphatemia
Levels of 'Hypophosphatemia Affect Outcome of Septic Patients in ICU
The current study aimed to determine the incidence of hypophosphatemia (HP) among severe sepsis/septic shock patients admitted to ICU and its impact on morbidity and mortality rates of these patients, and to evaluate the impact…
- Trial name
- NCT04519762
- Testing
- Glycophos (Sodium Glycerophosphate), Antibiotics, Inotropes
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Septic Shock
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
- Trial name
- NCT02060773
- Where
- China
- Sponsor
- Zhongda Hospital
Septic Shock, Hypertension
Effect of Different Strategies for Titrating a High MAP on Microcirculation
Assess the effect of fluids and norepinephrine for mean arterial pressure titration to patients' usual level on the microcirculation of initial resuscitated hypertensive septic shock patients.
- Trial name
- NCT02085291
- Testing
- Norepinephrine, Crystalloid
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Southeast University, China
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Stem Cell Transplant Complications
Prospective Validation of CARPET Prognostic Model for Septic Shock After Allo-HSCT
Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study
- Trial name
- NCT06022445
- Testing
- CARPET prognostic model
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Severe Sepsis With Septic Shock
Immune Reconstitution of Immunosuppressed Sepsis Patients
A multicenter, randomized, double-blinded, placebo-controlled study of two dosing frequencies of recombinant Interleukin-7 (CYT107) treatment to restore absolute lymphocyte counts in sepsis patients; IRIS-7A (Immune…
- Trial name
- IRIS-7a (NCT02797431)
- Testing
- Interleukin-7
- Where
- 3 sites in France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Limoges
Septic Shock
Evaluation of Sepsis-induced Immunosuppression Base on QuantiFERON Monitor® in Septic Shock
QuantiFERON Monitor® is an immunological test evaluating the nonspecific cellular response by measuring interferon gamma (IFNγ) secretions after T-cell and natural killer lymphocyte stimulation.
- Trial name
- MONITOR SEPSIS (NCT04320394)
- Testing
- QuantiFERON Monitor®
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis
Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis
Breath samples will be collected from patients suspected of sepsis/severe sepsis or septic shock according to hospital sepsis screening criteria in the Emergency Department.
- Trial name
- NCT03497182
- Testing
- Breath sample collection
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Landon Pediatric Foundation
Sepsis, Septic Shock
Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury
Populations at high risk of Sepsis-Associated Acute Kidney Injury (SA-AKI) have been identified. Sources of sepsis, in particular, bloodstream infection, abdominal and genitourinary sepsis, and infective endocarditis, are…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- RRIBIOSAKI (NCT03799159)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Islam Elsayed Mohamed Ahmed
Sepsis, Severe Sepsis
Subpopulation-Specific Sepsis Identification Using Machine Learning
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a subpopulation-optimized…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03644940
- Testing
- CustomSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
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