Clinical trials: Septicemic Shock
Sepsis, Septic Shock
ARTICE® Real Data Collection & Observational Trial, Phase 4 Study
The objectives of this registry study are to: 1. Record real-life data related to the use of the ARTICE® therapy in sepsis subjects. 2. Further evaluate ARTICE® treatment efficacy. 3.
- Conditions
- Sepsis, Septic Shock, Immunoparalysis in Septic Shock
- Trial name
- ARTistry (NCT07388628)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Artcline GmbH
Maternal sepsIs
Selective Lipopolysaccharide Hemosorption in Maternal Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million. The prevalence and frequency of obstetric sepsis are quite pronounced.
- Trial name
- MINERVA (NCT05711901)
- Testing
- Efferon LPS
- Where
- 7 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Efferon JSC
Severe Sepsis or Septic Shock
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)
Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition.
- Trial name
- PITSTOP (NCT03068741)
- Testing
- Comparison 1: Prehospital Ceftriaxone, Comparison 2: Liberal fluids, Comparison 2: Conservative fluids
- Where
- 4 sites in Canada
- Volunteers
- 2,061 people
- Sponsor
- Dr. Damon Scales
Shock, Septic Shock
LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock
Fluid responsive is defined as increasing in Cardiac output or Stroke volume by 10-15% after fluid challenge. Left ventricular diastolic dysfunction is associated with lower left ventricular end-diastolic volume (LVEDV) resulting…
- Trial name
- NCT05066256
- Testing
- Left ventricular diastolic function, Inferior vena cava variation
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Sepsis, Severe Sepsis
Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions
The German Quality Network Sepsis is an association trying to improve quality of care for patients with sepsis, severe sepsis and septic shock or being in risc thereof.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- icosmos (NCT02820675)
- Testing
- structured case analysis, strucured screening "every patient, every shift"
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Septic Shock, Sepsis
Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock
Compare the effect of volume expansion by saline versus albumin on the correction of peripheral tissue hypoperfusion by measuring Index skin recoloration time (CRT) at H0 and H1
- Trial name
- REPTILOS (NCT05094856)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Shock, Septic
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock
This is a randomised, double-blind, two-stage, placebo controlled study. It is designed to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of 3 doses of nangibotide versus placebo in adult patients…
- Trial name
- NCT03158948
- Testing
- Nangibotide 0.3 mg/kg, Nangibotide 1 mg/kg, Nangibotide 3 mg/kg
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 50 people
- Sponsor
- Inotrem
Septic Shock
Transfusion-requirements in Septic Shock Trial
Patients with blood poisoning - sepsis - often receive blood transfusions in the intensive care unit. The evidence that blood transfusion leads to improved outcome is limited and the blood may be harmful to some of these…
- Trial name
- TRISS (NCT01485315)
- Testing
- SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion
- Where
- 32 sites in Denmark, Finland and 2 more
- Volunteers
- 1,005 people
- Sponsor
- Scandinavian Critical Care Trials Group
Sepsis
Incidence of Sepsis After Craniocerebral Operation
To investigate the incidence and outcome of sepsis in critical patients undergoing craniotomy.
- Trial name
- NCT03803813
- Where
- China
- Volunteers
- 907 people
- Sponsor
- Jianfang Zhou
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Trauma Injury, Acute Coronary Syndrome
Smart Glasses in Emergency Medicine From the Hangzhou Asian Games
The findings of our study will reveal that using smart glasses in the emergency department(ED) could facilitate patient admission. AR Smart Glasses offer the potential to enhance the effectiveness and speed of treatment within ED.
- Conditions
- Trauma Injury, Acute Coronary Syndrome, Stroke, Acute, Septic Shock
- Trial name
- SGINHZAG (NCT06623825)
- Testing
- teleconsultation by Augmented Reality smart glasses, teleconsultation by two-way radio connection.
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sir Run Run Shaw Hospital
Septic Shock, Acute Kidney Injury
Early Endotoxin Burden Reduction With oXiris in Septic Shock Patients Requiring CRRT
The goal of this clinical trial is to learn whether continuous renal replacement therapy (CRRT) using the oXiris filter can lower the amount of endotoxin in the blood of adults with septic shock who need CRRT.
- Trial name
- NCT07807410
- Testing
- oXiris Hemofilter
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Shock, Septic, Sepsis
Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock.
In patients with septic shock, low levels of circulating immunoglobulins are common and they are kinetic, particularly of immunoglobulin M (IgM), seems to be related with clinical outcome.
- Conditions
- Shock, Septic, Sepsis, Hypoglobulinemia
- Trial name
- IgM-FAT (NCT04182737)
- Testing
- IgM-enriched polyclonal immunoglobulins titer-based treatment, IgM-enriched polyclonal immunoglobulins Flat treatment
- Where
- Italy
- Volunteers
- 356 people
- Sponsor
- Massimo Girardis
Shock, Hemorrhagic, Shock, Traumatic
Polydatin Injectable (HW6) for Shock Treatment
HW6 can prolong animal's survival time and increase the survival rate. HW6 enhances cardiac function, improves microcirculation, and increases blood pressure and pulse pressure, and improves blood perfusion of important organs…
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Shock, Septic
- Trial name
- PIST (NCT01780129)
- Testing
- Polydatin Injectable
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Neptunus Pharmaceuticals Inc.
Sepsis
Evaluation of Impaired Microcirculation During Septic Shock With Contrast Enhanced Ultrasound
Microcirculatory disorders play a central role in the pathogenesis of sepsis and septic shock. Without adequate therapy that may lead to multi-organ failure and death.
- Trial name
- NCT02277977
- Testing
- Contrast enhanced ultrasound
- Sponsor
- University Hospital Freiburg
Septic Shock
Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients
Compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C and evaluate intra-individual variation of hemodynamic parameters between T0 and T1.
- Trial name
- MYTHICCS (NCT04778605)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Terlipressin in Septic Shock: Effects on Microcirculation
The present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00995839
- Testing
- continuous infusion of terlipressin, Arginine vasopressin, terlipressin bolus administration
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients
The benefit of low-dose steroids in septic shock is still debated today, especially with mineralocorticoids. Fludrocortisone is a synthetic mineralocorticoid, an analogue of aldosterone, which has shown, in combination with…
- Trial name
- FLUDROSEPSIS (NCT05001854)
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
Septic Shock
Correlation of VEGF-A and Fluid Balance in Septic Shock
VEGF is a key molecule in the control of vascular permeability via interactions with the VEGF-receptor on the endothelial cell. Several authors reported plasma VEGF levels are elevated in sepsis shock and associated with…
- Trial name
- VEGFluid (NCT04474431)
- Testing
- Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Rouen
Cirrhosis With Septic Shock
Comparison And Outcomes Of Fluid Resucitation With 0.9% Normal Saline And 5% Albumin In Cirrhosis Patients With Sepsis Induced Hypotension
300 consecutive patients with cirrhosis of any aetiology admitted with features of sepsis and sepsis induced hypotension to the intensive care unit, the emergency department and the step down units of Institute of Liver and…
- Trial name
- NCT02462902
- Testing
- 5% albumin Infusion, 0.9% sodium chloride solution
- Where
- India
- Volunteers
- 308 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.