Clinical trials: Septicemic Shock
Severe Sepsis With Septic Shock
A Study of IL-7 to Restore Absolute Lymphocyte Counts in Sepsis Patients
A multicenter, randomized, double-blinded, placebo-controlled study of two dosing frequencies of recombinant Interleukin-7 (CYT107) treatment to restore absolute lymphocyte counts in sepsis patients; IRIS-7B (Immune…
- Trial name
- IRIS-7-B (NCT02640807)
- Testing
- Interleukin-7
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Revimmune
Sepsis, Septic Shock
Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study
Sepsis remains a leading cause of critical illness worldwide, yet the underlying mechanisms driving its profound and persistent immune dysfunction are incompletely understood.
- Trial name
- NCT07667153
- Testing
- Bone marrow aspirate collection
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
ARDS, Septic Shock
ARDS Prediction Score in Critically Ill Patients in China
ARDS is a severe disease, it's important to predict the incidence of ARDS.
- Trial name
- NCT02174081
- Where
- China
- Volunteers
- 698 people
- Sponsor
- Jianfeng Xie
Septic Shock
Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration
The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient.
- Trial name
- ECHO-VEVA (NCT07438301)
- Testing
- Echocardiogram
- Where
- Thailand
- Volunteers
- 180 people
- Sponsor
- Mahidol University
Septic Shock, Multiple Organ Dysfunction Syndrome
Therapeutic Plasma Exchange Adsorption Diafiltration
The purpose of this study is to evaluate the efficacy of coupled therapeutic plasma exchange adsorption diafiltration (PEAF )for treating septic shock with multiple organ dysfunction syndrome patients in ICU.
- Trial name
- PEAF (NCT03589378)
- Testing
- PEAF
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Shenzhen Second People's Hospital
Septic Shock
Rapid Administration of Insulin in Sepsis
The purpose of this study is to determine if a glucose-insulin-potassium (GIK) solution can be safely administered to patients with septic shock.
- Trial name
- NCT00823108
- Testing
- GIK
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Acute Kidney Injury Due to Sepsis
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock
The goal of this clinical trial is to evaluate the efficacy of a hemodynamic resuscitation protocol guided by the Venous Return Gradient (Pmsf - CVP), measured via the non-invasive arm cuff technique, in reducing the incidence of…
- Trial name
- NCT07481097
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Septic Shock, Peripheral Perfusion Index
Different Norepinephrine Doses on Accuracy of Peripheral Perfusion Index in Predicting Tissue Perfusion in Septic Shock Patients
This study aims to evaluate the impact of different norepinephrine doses on the accuracy of the peripheral perfusion index in predicting tissue perfusion in septic shock patients.
- Trial name
- NCT07330908
- Testing
- Group I: Patients will receive norepinephrine <0.15 µg/kg/min, Group II: Patients will receive norepinephrine ≥ 0.15 µg/kg/min
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Septic Shock
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation.
- Trial name
- NCT04136080
- Testing
- vasopressors
- Volunteers
- 752 people
- Sponsor
- Fujian Provincial Hospital
Sepsis, Septic Shock
Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock
Due to the high incidence, mortality and short and long term complications of sepsis and septic shock, it is necessary to look for strategies to try to minimize this impact.
- Trial name
- NCT04111822
- Testing
- red blood cells transfusion, tranexamic acid (TXA) and fibrinogen concentrate, on crystalloid fluid and Tranexamic acid
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Cristina Martinez
Arrhythmia, Hemorrhage
Suitability of Unobtrusive Bed Monitoring and Wrist-worn Heart Rate Monitor for Patient Monitoring
Novel technology enables it to monitor noninvasively the vital signs of a patient. Such a monitoring is immediately required to improve patient safety and to reduce hospital readmissions.
- Conditions
- Arrhythmia, Hemorrhage, Septic Shock, Consciousness, Loss of
- Trial name
- BedMon (NCT03572751)
- Testing
- Bed-, wrist- and ECG-sensor monitoring
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Tampere University Hospital
Sepsis, Severe Sepsis
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study
The primary objective is to demonstrate that the plasma inducible nitric oxide synthase (iNOS) assay (PliNOSa® test) has an acceptable relative risk ratio for predicting the onset of sepsis within 72 hours of testing when…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PliNOSa® Test (NCT01371929)
- Volunteers
- 166 people
- Sponsor
- Research & Diagnostic Antibodies
Septic Shock
Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients
The study measures the plasma and bronchoalveolar lavage fluid concentrations of linezolid in septic shock patients comparing with non-septic shock patients to confirm the impact of septic shock on PK/PD of linezolid.
- Trial name
- NCT03308227
- Volunteers
- 46 people
- Sponsor
- Southeast University, China
Shock, Septic, Ventricular Dysfunction, Left
Place of Echocardiography in IV Fluid Therapy in Patients With Septic Shock and Left Ventricular Systolic Dysfunction
IV fluid therapy remains an essential haemodynamic objective in the treatment strategy of septic shock. Left ventricular systolic dysfunction secondary to sepsis is observed in 40% and up to 65% of the population concerned.
- Trial name
- DYSPRED (NCT02899897)
- Testing
- echocardiography in IV fluid therapy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation. A Pilot Multicenter Randomized Controlled Trial. The goal of this clinical trial is the estimation of the efficacy and safety of hemoadsorption…
- Trial name
- HAdSS (NCT07661303)
- Testing
- Efferon LPS, Toramyxin PMX 20R, Jafron HA 330
- Where
- 7 sites in Russia
- Volunteers
- 76 people
- Sponsor
- Moscow Multidisciplinary Clinical Center "Kommunarka"
Tachycardia, Septic Shock
Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients
Clinical study suggests that beta-blockers by decreasing heart rate together with an increase in stroke volume do not negatively affect cardiac output allowing an economization of cardiac work and oxygen consumption in patients…
- Trial name
- NCT02188888
- Testing
- esmolol
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Roma La Sapienza
Sepsis, Septic Shock
Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis
Studies have demonstrated that the use of a procalcitonin (PCT)-guided algorithm in combination with clinical judgment was associated with reduced antibiotic use without impacting mortality or treatment failure.
- Conditions
- Sepsis, Septic Shock, Neoplasm, Critical Illness
- Trial name
- Pro-Can (NCT04203524)
- Testing
- Procalcitonin Levels, Control
- Where
- Jordan
- Volunteers
- 157 people
- Sponsor
- King Hussein Cancer Center
Septic Shock, Severe Sepsis
Early Use of Norepinephrine in Septic Shock Resuscitation
Current septic shock guideline recommends fluid resuscitation as the first treatment. Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid therapy.
- Trial name
- CENSER (NCT01945983)
- Testing
- Early norepinephrine
- Where
- Thailand
- Volunteers
- 310 people
- Sponsor
- Mahidol University
Sepsis
Early Resuscitation in Paediatric Sepsis Using Inotropes
Septic shock in children still carries substantial mortality and morbidity. While resuscitation with 40-60 mL/kg intravenous fluid boluses remains a cornerstone of initial resuscitation, an increasing body of evidence indicates…
- Trial name
- ANDES-CHILD (NCT06478797)
- Testing
- Fluid, Adrenalin
- Where
- 4 sites in Argentina, Bolivia and 1 more
- Volunteers
- 40 people
- Sponsor
- NATALIA LOPERA MUNERA
Septic Shock, Acute Renal Failure
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal…
- Trial name
- NCT00816790
- Testing
- Piperacillin/Tazobactam
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Fraser Health
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