Clinical trials: Septicemic Shock
Cardiomyopathies, Sepsis
Translational Approaches to Septic Cardiomyopathy
This translational study will assess the association between septic cardiomyopathy (measured via left ventricular global longitudinal strain) and (a) inflammatory cytokine profiles, and (b) the behavior of cardiomyocytes derived…
- Conditions
- Cardiomyopathies, Sepsis, Septic Shock
- Trial name
- TASC01 (NCT03252613)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Samuel Brown
Sepsis, Septic Shock
The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis
The purpose of this study is to evaluate the effect of high-dose ascorbic acid on microcirculation in sepsis.
- Trial name
- NCT04773717
- Testing
- Ascorbic acid
- Where
- Lithuania
- Volunteers
- 60 people
- Sponsor
- Lithuanian University of Health Sciences
Severe Sepsis, Septic Shock
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis
The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.
- Trial name
- NCT02576457
- Testing
- BMS-936559
- Where
- 13 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
Septic Shock
Population-Based Analysis of Incidence and Mortality of Septic Shock
RADAR-Septic Shock is a population-based observational study in Catalonia (Spain) that will identify all hospital discharges with septic shock between 2018 and 2023 using an audited population-based registry.
- Trial name
- RADAR (NCT07174765)
- Testing
- Person-level linkage of the database looking for relationship with septic shock survival and comorbidities, previous intake of medication, and previous dependence on health services.
- Where
- Spain
- Volunteers
- 31,480 people
- Sponsor
- Hospital de Granollers
Shock, Septic, Echocardiography
Strain Echocardiography During Septic Shock : an Observational Pilot Study
The mortality of septic shock remains high nowadays despite a trend toward improvement.Septic cardiomyopathy has been reported in most experimental models of sepsis shock. Its relationship with mortality is unclear.
- Trial name
- Sepsistrain (NCT03663192)
- Testing
- strain echocardiography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Severe Sepsis, Septic Shock
Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy
The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.
- Trial name
- SepsAR2 (NCT01926301)
- Testing
- continuous veno-venous hemodialysis
- Where
- Germany
- Sponsor
- Johannes Gutenberg University Mainz
Sepsis, Children, Only
Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children
The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored.
- Trial name
- NCT04794595
- Testing
- CBP
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Fudan University
Sepsis
Evaluation of Impaired Microcirculation During Septic Shock With Contrast Enhanced Ultrasound
Microcirculatory disorders play a central role in the pathogenesis of sepsis and septic shock. Without adequate therapy that may lead to multi-organ failure and death.
- Trial name
- NCT02277977
- Testing
- Contrast enhanced ultrasound
- Sponsor
- University Hospital Freiburg
Septic Shock, Hypoperfusion
Early Methylene Blue in the Microhemodynamics of Septic Patients
The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or…
- Trial name
- NCT07264543
- Testing
- Methylene blue infusion
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Septic Shock
Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT
To assess the efficiency and safety of combined extracorporeal blood purification in patients with septic shock in Neurosurgical ICU in comparison with the efficiency and safety of the continuous renal replacement therapy (CRRT).
- Trial name
- NEUROCOMB (NCT04152174)
- Testing
- Combined extracorporeal blood purification, CRRT
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Burdenko Neurosurgery Institute
Septic Shock
Phenylephrine in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to compare: the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic…
- Trial name
- NCT00639015
- Testing
- Phenylephrine, Norepinephrine
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
A Prediction Model of 28-day Mortality in Septic Shock
This clinical study adopts the design of cohort research, selects the sepsis shock patients admitted to our hospital ICU as the research object, takes the 28-day mortality rate as the outcome index, collects the baseline data of…
- Trial name
- NCT04915625
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infection, Sepsis
Short-course Antimicrobial Therapy in Sepsis
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
- Conditions
- Infection, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02899143
- Testing
- Antibiotic
- Where
- 4 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Ospedale Santa Maria delle Croci
Fungal Infection
The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock
To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic…
- Trial name
- NCT05642624
- Testing
- Deoxycholic acid amphotericin B
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Septic Shock
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the…
- Trial name
- NCT02706379
- Testing
- Local cerebral oxygen saturation
- Volunteers
- 26 people
- Sponsor
- Southeast University, China
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis
Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis
The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis, Septic Shock
- Trial name
- BULLSEYE (NCT06766461)
- Testing
- Double dosing of beta-lactam antibiotic
- Where
- Netherlands
- Volunteers
- 980 people
- Sponsor
- Erasmus Medical Center
Septic Shock
Survey of Non-resuscitation Fluids in Septic Shock
The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.
- Trial name
- SURF (NCT03438097)
- Where
- 9 sites in Canada, Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
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