Clinical trials: Septicemic Shock
Sepsis, Sepsis, Severe
EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock
This study is designed to improve the outcomes for patients suffering from severe sepsis and septic shock (SS/SS) by decreasing the time from first medical contact to antibiotic administration.
- Conditions
- Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04134624
- Testing
- Sepsis care bundle
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- HealthPartners Institute
Severe Sepsis, Septic Shock
A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock
The two co-primary objectives of this study are to assess in Japanese patients with severe sepsis and/or septic shock: 1) the safety and tolerability of two different doses of intravenous AZD9773 and 2) the PK of AZD9773.
- Trial name
- NCT01144624
- Testing
- AZD9773
- Where
- 7 sites in Japan
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Sepsis, Septic Shock
Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study
The performance and clinical impact of two diagnostic systems will be evaluated using whole blood samples that are collected in parallel with samples for blood culture.
- Conditions
- Sepsis, Septic Shock, Bacteremia
- Trial name
- FAPIC-QE (NCT04103203)
- Testing
- PathoRobot/ Patho-Doc Test result
- Where
- Belgium
- Volunteers
- 1,978 people
- Sponsor
- Hasselt University
Sepsis, Septic Shock
Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in Sepsis
The purpose of this study is to find out whether blood levels of two proteins, GDF-15 and LGALS3BP, measured at intensive care unit admission and at 72 hours, can help predict survival and organ dysfunction in adult patients with…
- Trial name
- NCT07906561
- Testing
- Serum GDF-15 and LGALS3BP Measurement
- Volunteers
- 150 people
- Sponsor
- Inonu University
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock
Renal Resistive Index in Septic Shock Patients
Septic shock is a condition of acute circulatory failure and is defined as a process that requires the use of vasopressors to ensure adequate tissue perfusion when hypotension develops.
- Trial name
- NCT06214715
- Testing
- Philips ultrasonography system
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Sepsis
Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis
Breath samples will be collected from patients suspected of sepsis/severe sepsis or septic shock according to hospital sepsis screening criteria in the Emergency Department.
- Trial name
- NCT03497182
- Testing
- Breath sample collection
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Landon Pediatric Foundation
Sepsis, Sepsis Associated Encephalopathy
EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes
To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes…
- Conditions
- Sepsis, Sepsis Associated Encephalopathy, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07760415
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xiangya Hospital of Central South University
Septic Shock
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock
The purpose of this study is to perform a pilot study to assess the potential use of Bevacizumab (a vascular endothelial growth factor (VEGF) inhibitor) in sepsis.
- Trial name
- NCT01063010
- Testing
- Bevacizumab
- Where
- 3 sites in United States
- Sponsor
- Beth Israel Deaconess Medical Center
Sepsis
Incidence of Sepsis After Craniocerebral Operation
To investigate the incidence and outcome of sepsis in critical patients undergoing craniotomy.
- Trial name
- NCT03803813
- Where
- China
- Volunteers
- 907 people
- Sponsor
- Jianfang Zhou
Septic Shock
Co-administration of Iloprost and Eptifibatide in Septic Shock Patients
Objective Evaluating the safety and efficacy of iloprost and eptifibatide co-administration compared to placebo as an addition to standard care in septic shock patients.
- Trial name
- CO-ILEPSS (NCT02204852)
- Testing
- Iloprost+eptifibatide
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Sisse R. Ostrowski, MD PhD DMSc
Septic Shock
Adjunctive Methylene Blue in Septic Shock
Adjunctive Methylene BLUe in Septic SHock (BLUSH) is a single centre concealed-allocation parallel-group open-label randomized controlled pilot trial to ascertain the feasibility of a trial evaluating the efficacy and safety of…
- Trial name
- BLUSH (NCT06900140)
- Testing
- Methylene Blue, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Shannon M. Fernando
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock, Acute Kidney Injury
The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock
The purpose of this study is to evaluate renal effects of 3 different levels of mean arterial pressure in early case of septic shock.
- Trial name
- NCT02453425
- Testing
- MAP 60 mmHg, MAP 75 mmHg, MAP 90 mmHg
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Sahlgrenska University Hospital
Post Extubation Respiratory Failure, Re-intubation
Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients
Post extubation respiratory failure occur in 30% of extubated patients. More than 50% of them required reintubation. Noninvasive positive pressure ventilation (NIV) had been reported as an effective tool to prevent post…
- Conditions
- Post Extubation Respiratory Failure, Re-intubation, Septic Shock, Severe Sepsis
- Trial name
- NCT03246893
- Testing
- Noninvasive positive pressure ventilation, High flow oxygen nasal cannula
- Where
- Thailand
- Volunteers
- 222 people
- Sponsor
- Mahidol University
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Terlipressin, Septic Shock
The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients
Terlipressin becomes a vasopressin for septic shock. But some studies found it may lead to severe intesitnal complications such as intestinal ischemia.
- Trial name
- NCT02306239
- Testing
- Terlipressin, Norepinephrine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Liu ZiMeng
Iron-deficiency, Iron Deficiency Anemia
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
Anemia is a common health problem. Depending on a geographical region, anemia affects even 50% of population. Among patients admitted to the intensive care unit (ICU) anemia may affect as much as 66% of patients.
- Conditions
- Iron-deficiency, Iron Deficiency Anemia, Anemia of Chronic Disease, Sepsis
- Trial name
- NCT05217836
- Testing
- ferritin; iron; transferrin; transferrin saturation; hemoglobin in reticulocyte; hepcidin
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Silesia
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