Clinical trials: Septicemic Shock
Septic Shock
The Diagnostic and Prognostic Value of Presepsin in Sepsis
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or…
- Trial name
- NCT06180265
- Testing
- presepsin, procalciton, endotoxin
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Foggia
Severe Sepsis, Severe Sepsis Without Septic Shock
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support…
- Trial name
- NCT05304728
- Where
- 10 sites in United States
- Volunteers
- 40,000 people
- Sponsor
- Beckman Coulter, Inc.
Septic Shock
Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial
This is a double-blind, randomised, placebo-controlled, two-part adaptive clinical trial. The trial is designed to investigate the efficacy and safety of multiple dosing regimens of selepressin and to confirm the efficacy and…
- Trial name
- SEPSIS-ACT (NCT02508649)
- Testing
- selepressin
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 868 people
- Sponsor
- Ferring Pharmaceuticals
Septic Shock
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.
- Trial name
- NCT03872011
- Testing
- Vitamin C,thiamine,hydrocortisone
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Northern Jiangsu People's Hospital
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Cytokine Response in Septic Shock
This study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease.
- Trial name
- NCT01770457
- Where
- Canada
- Volunteers
- 325 people
- Sponsor
- University of Manitoba
Hyperlactatemia
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients
The study aimed to assess the effectiveness of intravenous thiamine as compared with placebo in reducing the lactate level in septic shock patients.
- Trial name
- NCT03649009
- Testing
- Normal Saline, Thiamine, Hydrocortisone
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Intra-Abdominal Infections
Abdominal SepsiS Study: Epidemiology of Etiology and Outcome
The aim of the project is to perform a multinational, prospective, observational study on IAIs (IntraAbdominal Infections) in critically ill patients; special emphasis will be given to epidemiology and outcomes.
- Trial name
- AbSeS (NCT02442596)
- Where
- Belgium
- Volunteers
- 2,200 people
- Sponsor
- European Society of Intensive Care Medicine
Severe Sepsis, Septic Shock
Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)
The purpose of this trial is to determine the influence of colloid versus crystalloid volume resuscitation and of intensive vs conventional insulin therapy on morbidity and mortality of patients with severe sepsis and septic…
- Trial name
- NCT00135473
- Testing
- 10% Hemohes® (10% Hydroxyethyl starch), Sterofundin® (Ringer lactate solution), Actrapid® (Insulin)
- Where
- 16 sites in Germany
- Volunteers
- 600 people
- Sponsor
- SepNet - Critical Care Trials Group
Septic Shock, Mechanical Ventilation Complication
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
Sedation and analgesia in patients with sepsis and hemodynamic instability may be challenging in the ICU. Opioids and propofol can further exacerbate tissue infusion in septic shock by reducing cardiac contractility, increasing…
- Trial name
- NCT05839366
- Testing
- Esketamine, Saline, Remifentanil + propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Sepsis, Severe Sepsis
Endothelium in Severe Sepsis
The overall hypotheses of this project is that severe sepsis is associated with endothelial dysfunction; that endothelial dysfunction, in turn, is predictive of subsequent organ failure and death; and that protocolized…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT00793442
- Testing
- Blood Collection and Assays
- Where
- 7 sites in United States
- Volunteers
- 910 people
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit
Goals Primary: compare changes in norepinephrine requirements before and after hemoperfusion (HP) treatment. Secondary: demonstrate the decrease in levels of IL-6 , assess the total and individual change of SEQUENTIAL ORGAN…
- Trial name
- NCT04231695
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Jose Maria Cullen
Septic Shock, Sepsis
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation…
- Conditions
- Septic Shock, Sepsis, Pathologic Processes, Shock
- Trial name
- UC-CISSII (NCT05969275)
- Testing
- Allogeneic umbilical cord-derived human mesenchymal stromal cells
- Where
- 2 sites in Canada
- Volunteers
- 296 people
- Sponsor
- Ottawa Hospital Research Institute
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock
Therapeutic Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of critical organ dysfunction in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high (> 60%).
- Trial name
- EXCHANGE (NCT04231994)
- Testing
- TPE
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Ketamine, Fentanyl
Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock
Ketamine is a commonly used drug for sedation and induction of anesthesia in patients with shock and/or cardiac dysfunction. Ketamine is characterized by its cardiovascular stimulatory effect due to increase release of endogenous…
- Conditions
- Ketamine, Fentanyl, Septic Shock
- Trial name
- NCT05957302
- Testing
- Ketamine, Fentanyl
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Cairo University
Septic Shock, Sepsis
Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality
The study aims to determine whether the infusion of DEX in septic shock can reduce in-hospital mortality, norepinephrine infusion, need and duration for mechanical ventilation, and acute kidney injury without significant adverse…
- Trial name
- DECATSepsis (NCT05283083)
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Sepsis
ASpirin for Patients With SEPsis and SeptIc Shock
This Randomized, pragmatic, multicentric with blinding of patients and health professionals, intention-to-treat analysis has by primary endpoint to evaluate whether the aspirin use reduces the intensity of organic dysfunction…
- Trial name
- ASP-SEPSIS (NCT01784159)
- Testing
- Aspirin
- Where
- Brazil
- Volunteers
- 167 people
- Sponsor
- Federal University of São Paulo
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