Clinical trials: Septicemic Shock
Burns, Sepsis
Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients
The investigators will compare the efficacy of Interleukin-6 (IL-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early ICU discharge.
- Conditions
- Burns, Sepsis, Septic Shock, Death
- Trial name
- NCT06915974
- Testing
- Interleukin 6
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Septic Shock
A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock
To assess the performance of the CytoSorb® 300 mL device for shock reversal in patients with vasoplegic septic shock.
- Trial name
- PROCYSS (NCT04963920)
- Testing
- Cytosorb® 300 ml
- Where
- 18 sites in Germany
- Volunteers
- 260 people
- Sponsor
- CytoSorbents Europe GmbH
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Septic Shock
Initiation of Hydrocortisone for the Treatment of Septic Shock
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
- Trial name
- NCT02580240
- Testing
- Hydrocortisone, saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Northern Jiangsu People's Hospital
Septic Shock
Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study
The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.
- Trial name
- CONSCIOUS (NCT02237833)
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Karl-Andre Wian
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Septic Shock
Treatment of Severe Infections With Mesenchymal Stem Cells
The main purpose at the early phase of septic shock on the evolution of organ failure judged by the SOFA (Sepsis Organ Failure Assessment score) score on Day 7 (or the day of death or the day of discharge from the intensive care…
- Trial name
- CHOCMSC (NCT02883803)
- Testing
- Injection of mesenchymal stem cells, Injection of albumin alone
- Where
- 4 sites in France
- Volunteers
- 66 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Severe Sepsis
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
In this study, the investigators will dynamically detect the expression of an immune regulator- T cell Ig and mucin domain protein 3 (Tim-3) in patient with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02180009
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Neonatal Disease
Analysis of Differential Proteins and Maternal Influencing Factors of Septic Shock in Neonates
1. Explore 32 weeks of premature infants or maternal pregnancy infection of newborn septic shock maternal influence factors. 2. Through maternal blood samples before delivery and labor cord blood sample screening and septic shock…
- Trial name
- NCT06206590
- Testing
- Whole-proteomic assay
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Guangdong Women and Children Hospital
Sepsis, Septic Shock
Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock
Sepsis is a term which describes an excessive response of the body to an infection and, if not promptly treated, can turn into septic shock a condition in which the organs don't receive enough oxygen to satisfy their needs.
- Trial name
- NCT06853574
- Testing
- Fluid therapy, Noradrenaline infusion
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- General and Teaching Hospital Celje
Fluid Refractory Septic Shock, Septic Shock
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children.
- Trial name
- NCT07273526
- Testing
- Adrenaline, Dopamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Laiba Qamar
Septic Shock, Sepsis
The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
- Trial name
- NCT04644926
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 26 people
- Sponsor
- Lithuanian University of Health Sciences
Sepsis, Septic Shock
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality.
- Conditions
- Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload
- Trial name
- TFC-SEPSIS (NCT06572995)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
Shock, Septic
Sevoflurane Sedation in Patients With Septic Shock
Recent in vivo studies from others as well as the investigators group demonstrated that volatile anesthetics immunomodulate sepsis and improve outcome.
- Trial name
- SSiS (NCT03643367)
- Testing
- Sevoflurane, Control Group
- Where
- 4 sites in Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Septic Shock
Hemodynamic Effects of Vasopressin in Early Septic Shock Stage
Vasopressin is a vasopressor used in patients with septic shock. However, its systemic hemodynamic effects and its microcirculation effects are not completely known and understood.
- Trial name
- NCT02053675
- Testing
- Vasopressin infusion
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Septic Shock, Vascular Dysfunction
Shenfu Injection Modulates Carotid Elasticity in Septic Shock
What is this study about? We are studying whether Shenfu Injection (a traditional Chinese herbal medicine) can help improve blood vessel health in patients with septic shock-a severe complication of infections that can damage…
- Conditions
- Septic Shock, Vascular Dysfunction, Arterial Stiffness, Carotid Artery Elasticity Alterations
- Trial name
- NCT06915506
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 48 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis, Septic Shock
Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey
The goal of this observational study is to validate the effectiveness of the new SOFA-2 score in predicting mortality and to determine the current frequency of sepsis in adult patients admitted to Intensive Care Units (ICUs) in…
- Conditions
- Sepsis, Septic Shock, Critical Illness, Organ Dysfunction
- Trial name
- TURK-SOFA2 (NCT07300306)
- Where
- Turkey (Türkiye)
- Volunteers
- 3,379 people
- Sponsor
- Marmara University
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