Clinical trials: Sequelae
Long COVID
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called "brain fog").
- Trial name
- NCT06821087
- Testing
- Ketamine only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
Post-Acute COVID-19 Syndrome
A Study of Positive Emotions With Long COVID-19
This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term…
- Trial name
- NCT05676008
- Testing
- Microdosing of mindfulness
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, Davis
Severe Trophic Corneal Ulcers Refractory to Conventional Treatment, Sequelae of Previous Trophic Corneal Ulcers
Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment
This is a prospective, phase I-II, randomised, open-label clinical trial that will evaluate the safety and feasibility, as well as clinical efficacy evidence, of a bioengineered anterior corneal substitute in adults with severe…
- Trial name
- NCT01765244
- Testing
- Anterior lamellar nanostructured artificial human cornea., Amniotic membrane transplantation
- Where
- 11 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
COVID-19, Fibrosis
Covid-19 Respiratory Sequelae French Cohort
As the investigators need data on long term outcome of Covid-19, especially respiratory sequelae, a national cohort is required.
- Conditions
- COVID-19, Fibrosis, Cohort, Follow-up
- Trial name
- PNEUMOCOVID (NCT05075785)
- Where
- France
- Volunteers
- 2,933 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Post-Acute COVID-19 Syndrome
Role of OMT in the Management of the Persistent Post-COVID-19 Symptoms
The goal of this observational study is to determine the feasibility of conducting a large-scale study on the effect of using osteopathic manipulative treatment (OMT) to treat patients with post-COVID-19 symptoms.
- Trial name
- ROMPS (NCT06016543)
- Testing
- osteopathic manipulative treatment (OMT)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- A.T. Still University of Health Sciences
NSCLC
Prophylactic Cranial Irradiation (PCI) Cognitive Tests in Non-small Cell Lung Cancer (NSCLC) Patients
Stage III non-small cell lung cancer (NSCLC) patients constitute a significant proportion of the lung cancer population. The prognosis of these patients has improved over the years due the introduction of combined modality…
- Trial name
- NCT01290809
- Where
- 4 sites in Netherlands
- Volunteers
- 170 people
- Sponsor
- Maastricht Radiation Oncology
Pelvic Inflammatory Disease, Chronic Pelvic Pain Syndrome
Clinical Trial of Acupoint Application in Improving the Sequelae of Pelvic Inflammatory Disease and Chronic Pelvic Pain
Chronic Pelvic Pain is one of the common gynecological symptoms, characterized by persistent and non periodic pain in the pelvic cavity and surrounding tissues.
- Trial name
- NCT06360965
- Testing
- Improved warm meridians and relieve pain plaster, Traditional warm meridians and relieve pain plaster
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
COVID-19, Chronic Liver Failure
Evaluation of Long Haul COVID-19 and Vaccine Immunogenicity in Patients With Liver Disease
The project is essential to understand the impact of the COVID-19 pandemic in patients with Chronic Liver Disease (CLD). The impact has been felt due to direct risk of COVID infection in self, or in caregivers, lack of access to…
- Conditions
- COVID-19, Chronic Liver Failure, Cirrhosis, Liver, Portal Hypertension
- Trial name
- EvaLongCovid (NCT05107271)
- Testing
- COVID-19 serosurvey
- Where
- India
- Volunteers
- 252 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ischemic Stroke, Adverse Effect of Thrombolytic Drugs, Sequela
Hospital Processes Reengineering of Intravenous Thrombolysis in Acute Ischemic Stroke in China
PROMISE is a prospective, nationwide, multicenter, longitudinal cohort study, focusing on hospital intravenous thrombolysis process reengineering for acute ischemic stroke (AIS).
- Trial name
- PROMISE (NCT02631317)
- Testing
- Advance hospital notification by EMS, stroke team notification, key performance indicators feedback form
- Volunteers
- 2,178 people
- Sponsor
- First Affiliated Hospital of Jinan University
Depression, Closed Head Injury
TMS in the Treatment of the Sequelae of Closed Brain Injury
Depression is very common in people who have experienced a traumatic brain injury. Few treatments have been found to be effective in treating depression in this situation.
- Trial name
- NCT00531258
- Testing
- rTMS
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- Bayside Health
Telerehabilitation, Stroke Sequelae
Mobile App as a Guide to Exercises for Patients With Chronic Stroke
Introduction: Stroke continues to be one of the leading causes of disability in the Spanish adult population with the presentation of impairments such as alteration of mobility and a consequent reduction in quality of life.
- Conditions
- Telerehabilitation, Stroke Sequelae, Therapeutic Adherence and Compliance, Mobile Phone Use
- Trial name
- NCT04477252
- Testing
- App-core, Conventional physiotherapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Clínica de Neurorehabilitación
Posterior Urethral Valve
Overnight Bladder Drainage and Posterior Urethral Valve Sequelae
We hypothesize that overnight catheter drainage (OCD) of the urinary bladder might improve bladder dynamics and subsequently lead to improvement or resolution of hydronephrosis (HN) and renal function in boys who underwent PUV…
- Trial name
- NCT05168358
- Testing
- Overnight Bladder Drainage
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Mansoura University
Long COVID, Post COVID-19 Condition
Effect of Hi-OxSR for the Treatment of Post COVID Condition
The RECLAIM study platform will be used to explore whether the use of the Hi-OxSR device improves the symptoms of post covid cognitive dysfunction.
- Conditions
- Long COVID, Post COVID-19 Condition, Post Acute Sequelae of COVID-19
- Trial name
- RECLAIM-HiOxSR (NCT06928506)
- Testing
- Hi-OxSR device, Hi-Ox device
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
B-ALL, Hematologic Malignancy
Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy
This study is being done to learn more about the short-term and long-term side effects of CAR-T cell therapy. Specifically, researchers want to know how often patients get infections, have delays in recovering blood cell counts…
- Conditions
- B-ALL, Hematologic Malignancy, Solid Tumor
- Trial name
- NCT06579469
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- St. Jude Children's Research Hospital
Post-acute Sequelae SARS-CoV-2 Infection (PASC)
TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms
The overarching goals of this study are to employ cognitive testing to understand how transcranial direct current stimulation (tDCS), when used concurrently with cognitive training tasks, can affect cognitive impairment symptoms…
- Trial name
- NCT05589272
- Testing
- Active tDCS
- Where
- United States
- Sponsor
- University of Minnesota
Ebola Virus Disease
Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease (EVD) Survivors in PREVAIL III
Background: Ebola virus disease (EVD) is a viral fever that can cause internal bleeding. The death rate from EVD is very high. In a 2014 outbreak in West Africa, 28,000 were affected and 11,000 died.
- Trial name
- NCT05494801
- Where
- Liberia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Follow-up of Covid-19 Long Term Sequelae
The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05097677
- Testing
- Not applicable (observational study)
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 7,599 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pediatric Cancer
LIFE Cancer Survivorship Database for Pediatric Cancer
The purpose of this study is to develop a mechanism for utilizing the comprehensive clinical database of childhood cancer survivors at Childrens Hospital Los Angeles (CHLA) for research purposes.
- Trial name
- NCT01518400
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital Los Angeles