Clinical trials: Sequence Analysis
Chronic Postsurgical Pain
CSF Single-cell Sequencing and Proteomics of Chronic Postsurgical Pain in Patients With Lower Limb Fractures
The purpose of this study is to assess the proteomics and transcriptomic differences between pain-free control subjects and patients with chronic postoperative pain through single-cell sequencing technology.
- Trial name
- NCT06126289
- Volunteers
- 20 people
- Sponsor
- Xuzhou Central Hospital
Myeloma
Assessing the Relationship Between Hypoxia and the Immune Environment in Myeloma Patients (CHIME)
The study is looking at how myeloma is related to low oxygen levels (hypoxia) in the bone marrow. This is to understand the disease better. It might also guide treatment in the future.
- Trial name
- CHIME (NCT06007989)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- The Christie NHS Foundation Trust
Genetic Disease, Neurologic Disorder
Use of Long Read Genome Sequencing in Patients Suffering From Neurodevelopmental Troubles
Patients with neurodevelopmental diseases and their families need to identify the genetic cause of the disease to allow for recognition of the disability, genetic counseling, and possible hope for participation in therapeutic…
- Conditions
- Genetic Disease, Neurologic Disorder, Developmental Delay Disorder, Growth Disorders
- Trial name
- HiFi-NDD (NCT05643274)
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- Nantes University Hospital
Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC)
Liquid BiOpsy, Lung and Colon Cancer in AndaluciA
The objective of the LOLA Project is to analyse the impact of adopting xF liquid biopsy panel, in the real world of the Andalusian Health Public System in terms of impact on clinical practice and cost through the assessment of…
- Trial name
- LOLA-PROJECT (NCT06997458)
- Testing
- xF Tempus assay
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Unilateral Lower Limb Suspension
Single Nuclei Sequencing in Human Skeletal Muscle After Unloading
Injuries often require people to undergo some degree of limb immobilization. This comes at a high cost in terms of muscle mass and function losses.
- Trial name
- ULLS23 (NCT05801185)
- Testing
- Unilateral lower limb suspension
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Intellectual Disabilities, Congenital Anomaly
Genome Medical Sequencing for Gene Discovery
Background: A number of rare inherited diseases affect only a few patients, and the genetic causes of these conditions remain unknown.
- Conditions
- Intellectual Disabilities, Congenital Anomaly, Rare Disorders
- Trial name
- NCT01087320
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Varicose Veins
Clinical Investigation and Molecular Forms of Family Disease of Varicose
The existence of a family factor in the genesis of varicose veins is certain, but few studies have addressed reliably instead of the genetic factor in clinical and molecular level.
- Trial name
- NCT02870127
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 430 people
- Sponsor
- Nantes University Hospital
Hematologic Neoplasms
Feasibility Study of Genomic Sequencing to Find Potential Targets for Personalized Therapy
This study is aimed to determine the feasibility of obtaining and molecularly characterizing pre-treatment tumor biopsies, to determine the feasibility of obtaining and molecularly characterizing archival and post-treatment tumor…
- Trial name
- NCT01869218
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Lung Infection
Next-generation Sequencing Technology in the Clinical Application of Respiratory Specimens
Obtain the performance parameters and clinical consistency of mNGS and tNGS technologies in the pathogen diagnosis of lower respiratory tract specimens from patients with severe pulmonary infections, to provide a reference basis…
- Trial name
- NCT07191080
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Bin Zhang
Immunodepressed Patients (Hemato-oncology)
Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
The development of targeted therapies and intensive protocols in oncohaematology has improved the survival of patients with haematological malignancies.
- Trial name
- ADNEMIA (NCT06075888)
- Testing
- Metagenomic diagnosis (mNGS, DISQVER)
- Where
- 5 sites in France
- Volunteers
- 184 people
- Sponsor
- Poitiers University Hospital
Non-Small Cell Lung Cancer, Squamous Non-small-cell Lung Cancer
A Study of Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer
This is a multicenter, randomized, open-label Phase 2 study of sapanisertib in biomarker-defined populations of sqNSCLC. Patients with NFE2L2 (the name for gene encoding the protein called NRF2)-mutated or wild-type sqNSCLC…
- Conditions
- Non-Small Cell Lung Cancer, Squamous Non-small-cell Lung Cancer, Squamous Non-Small Cell Neoplasm of Lung, NFE2L2 Gene Mutation
- Trial name
- NCT05275673
- Testing
- sapanisertib
- Where
- 14 sites in United States
- Volunteers
- 7 people
- Sponsor
- Faeth Therapeutics
Dystonia, Movement Disorders
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia
Dystonia is a motor disorder caused by involuntary, intermittent, or sustained muscle contractions, leading to abnormal movements or postures.
- Conditions
- Dystonia, Movement Disorders, Combined Dystonia, Complex Dystonia
- Trial name
- GenoDYT (NCT06999096)
- Testing
- Long-read whole genome sequencing
- Where
- 4 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Genetic Disease, Genetic Syndrome
Diagnostic Odyssey: Whole Genome Sequencing (WGS)
The goal of this collaborative research is to study human genomes in children with suspected congenital disease, multiple-congenital anomalies and/or multi-organ disease of unknown etiology by understanding the potential value of…
- Trial name
- NCT03458962
- Testing
- Genetic Enrollees
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Upper Urinary Tract Urothelial Carcinoma
Neoadjuvant Nivolumab for Upper Tract Urothelial Carcinoma
The aim of this study is to explore efficacy and safety of neoadjuvant nivolumab for non-metastatic upper tract urothelial carcinoma (UTUC), and explore the potential predictive biomarkers of immunotherapy.
- Trial name
- NCT05160285
- Testing
- Nivolumab 100 MG in 10 ML Injection
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- YULISU
MRSA
Tracing MRSA in Households With Patients Infected With CA-MRSA by WGS
From the 1980s to the late 1990s, highly toxic methicillin-resistant Staphylococcus aureus (MRSA) strains (called community-associated [CA] MRSA) appeared in the community.
- Trial name
- NCT04312776
- Testing
- none intervention
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Non Small Cell Lung Cancer Patients
Analysis of Plasma Tumor DNA in Lung Cancer Patients
The presence of genetic alterations in the tyrosine kinase domain of the oncogene (eg. EGFR and ALK) is associated with the clinical response to tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancers.
- Trial name
- NCT01930474
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
HIV
Genotypic Tropism Testing In Proviral Dna To Guide CCR5 Antagonist Treatment In Subjects With Undetectable HIV-1 Viremia
CCR5 antagonists might be an adequate alternative for HIV-1-infected individuals with suppressed viremia who experience antiretroviral-related toxicity.
- Trial name
- NCT01378910
- Testing
- Unique
- Where
- 24 sites in Spain
- Volunteers
- 74 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Congenital Heart Disease
Genetics of Congenital Heart Disease
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown.
- Trial name
- NCT01192048
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital