Clinical trials: Serious Illness
Schizophrenia, Schizoaffective Disorder
Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)
The overall goal of this project is to improve the treatment of alcohol dependence in patients with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Alcohol Dependence
- Trial name
- vivitrol (NCT00453609)
- Testing
- long-lasting injectable naltrexone
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Malignant Neoplasm, Carcinoma
Short-term Psychodynamic Psychotherapy in Serious Physical Illness
Life-threatening physical illness may powerfully re-activate existential conflict. There is little evidence to date on the effectiveness of relationship-focused therapies in this patient group.The aim of this study is to pilot a…
- Conditions
- Malignant Neoplasm, Carcinoma, Palliative Care
- Trial name
- ORPHYS (NCT05520281)
- Testing
- Short-term psychodynamic psychotherapy for patients with serious physical illness (ORPHYS)
- Where
- 4 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Serious Mental Illness
Coach to Fit Weight Loss Intervention for Individuals With Serious Mental Illness
This project addresses obesity in the population with SMI by evaluating a weight management program that is not only evidence-based, it is sustainable, transportable, appealing to patients, easy to use, and minimally burdensome…
- Trial name
- C2F (NCT04560335)
- Testing
- Coach to FIt, Treatment as Usual
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- VA Office of Research and Development
Serious Mental Illness
Peer Facilitated Waitlist Controlled Transportation Study
The goal of this clinical trial is to test the effectiveness of a peer-facilitated travel intervention in adults with serious mental illnesses. This project aims to address the following hypotheses: 1.
- Trial name
- NCT06370767
- Testing
- Bike-Share Travel Training, Public Transportation Travel Training
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Temple University
Care Transitions
Improving Care Transitions for Medicaid Insured Individuals With Co-occurring Serious Mental Illness
This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization.
- Trial name
- THRIVE-SMI (NCT06203509)
- Testing
- Thrive Intervention
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Schizoaffective Disorder, Schizophrenia
Smoking Cessation for Veterans With Severe and Persistent Mental Illness
The investigators have developed an intervention called Behavioral Treatment of Smoking Cessation in SPMI (BTSCS), an innovative intervention that supplements pharmacotherapy and education with contingency management and a…
- Conditions
- Schizoaffective Disorder, Schizophrenia, Affective Psychosis, Bipolar, Affective Disorders, Psychotic
- Trial name
- NCT00960375
- Testing
- BTSCS, StSST
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- US Department of Veterans Affairs
Schizoaffective Disorder, Schizophrenia
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
Testing an mHealth mobile interventionist texting program on illness management.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT03062267
- Testing
- Mobile Interventionist
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Washington
Mental Disorders
Enhanced Medication Reconciliation For Serious Mental Illness
The purpose of this study is to evaluate the clinical utility of a decision support tool, the Patient Medication Profile(TM), developed by Sano Informed Prescribing on medication reconciliation and identification of drug-related…
- Trial name
- NCT03169868
- Testing
- Sano Patient Medication Profile
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Precera Bioscience, Inc.
ESRD, Peritoneal Dialysis
Evaluate Serious Illness Treatment Preferences and Outcomes in the Patients Receiving Peritoneal Dialysis
The goal of this clinical research study is to study the cardiopulmonary resuscitation (CPR) preferences of patients receiving peritoneal dialysis and how these preferences are associated with their responses to questions about…
- Trial name
- NCT05193474
- Testing
- integrated palliative care
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Obesity
Peer-Led Healthy Lifestyle Program in Supportive Housing
This goal of this randomized controlled effectiveness trial is to compare the effectiveness of a peer-led health lifestyle intervention (Peer GLB) versus usual care services in supportive housing agencies in New York City and…
- Trial name
- NCT02175641
- Testing
- Peer-Led Group Lifestyle Balance, Usual Care Services
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Washington University School of Medicine
Obesity, Mental Disorder
Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness
People with serious mental illness such as schizophrenia and bipolar disorder experience high rates of physical illness and die earlier than people without serious mental illness (WHO, 2005).
- Trial name
- NCT03382782
- Testing
- BWLI, BWLI & Peer Navigator, Integrated Care
- Where
- 3 sites in United States
- Volunteers
- 234 people
- Sponsor
- Illinois Institute of Technology
Schizophenia Disorder, Schizoaffective Disorder
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
The goal of this study is to reduce Anticholinergic Medication (ACM) in persons with psychoses or serious mental illness, when these medications are no longer needed.
- Conditions
- Schizophenia Disorder, Schizoaffective Disorder, Bipolar Disorder, Psychiatric Disorders
- Trial name
- RAMP (NCT07043803)
- Testing
- Reduction of anticholinergic medication
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh
Palliative Care
Study to Improve Care for Veterans During Serious Illness
Improving end-of-life care is of critical importance to the VA as it faces an increasingly aging and dying veteran population. Previous work within and outside of the VA has demonstrated serious deficiencies in the quality of…
- Trial name
- NCT00106041
- Testing
- Veterans Integrated Palliative Care Nurse Case Manager
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- US Department of Veterans Affairs
Epilepsy, Schizophrenia
Targeted Self-Management for Epilepsy and Serious Mental Illness (TIME)
For this project we propose to refine the psychosocial intervention developed in phase one, based on input from key stakeholders, and to test the feasibility, acceptability and preliminary efficacy of the intervention.
- Conditions
- Epilepsy, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT01992393
- Testing
- TIME
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Case Western Reserve University
Serious Mental Illness, Tobacco Use Disorder
Facilitation to Increase Tobacco Treatment
Smoking disproportionally impacts Veterans, and VA spends $2.7 billion annually on smoking-related health conditions. Veterans with serious mental illness (SMI) smoke tobacco products at triple the rate of Veterans without any…
- Trial name
- FITT (NCT07455526)
- Testing
- Multi-component facilitation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Food Cravings, rTMS
The Effectiveness of rTMS on Improving Food Craving and Weight Control in Adults Without Serious Mental Illness
Department of Psychiatry | Li Ka Shing Faculty of Medicine The University of Hong Kong The Effectiveness of rTMS on Improving Food Cravings and Weight Control in Adults without Serious Mental Illness Introduction The…
- Trial name
- NCT07106398
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Mental Disorders
Integrated Care & Patient Navigators for Latinos With Serious Mental Illness
The health care needs of people with serious mental illness are exacerbated by ethnic health disparities. Latinos with serious mental illness show significant health problems compared to other ethnic groups.
- Trial name
- NCT02469714
- Testing
- Peer Navigator Intervention
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Illinois Institute of Technology
Oncology
Remote Education Strategies Training Oncology Residents for End-of-Life Discussions
Difficult conversations are common in oncology practice and patient-centered communication is essential to care for individuals with cancer.
- Trial name
- RESTORED (NCT05810987)
- Testing
- RESTORE, Medical Interaction and Coaching
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University
End-Stage Liver Disease
Surprise Question in End of Life (SeQuEL) Care and the Effect of Prompting Palliative Care Consultation: End-Stage Liver Disease
This is a single center randomized platform trial determining whether prompting consideration of palliative care consultation through the electronic health record impacts the number of palliative consultations placed and…
- Trial name
- SeQuEL (NCT06400498)
- Testing
- Prompted Palliative Care Consult
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Overweight
Interactive Obesity Treatment Approach for Obesity Prevention in Adults With Early Serious Mental Illness: iOTA-SMI
Using a design-for-dissemination approach, this application proposes to use combined methods to adapt and pilot test an interactive obesity treatment approach (iOTA) for obesity prevention in early serious mental illness (eSMI)…
- Conditions
- Obesity, Overweight, Severe Mental Disorder
- Trial name
- iOTA-eSMI (NCT03980743)
- Testing
- iOTA text messaging intervention, Health Education text messaging intervention
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine