Clinical trials: Serious Illness
Chronic Disease, Mental Disorder
Reducing Cardiovascular Risk in Adults With Serious Mental Illness
This purpose of this study is to adapt, implement and test the ability of a sophisticated point-of-care electronic health record-based clinical decision support that identifies and prioritizes all available evidence-based…
- Conditions
- Chronic Disease, Mental Disorder, Health Behavior, Bipolar Disorder
- Trial name
- SMIWizard (NCT02451670)
- Testing
- Prioritized Clinical Decision Support
- Where
- 3 sites in United States
- Volunteers
- 10,347 people
- Sponsor
- HealthPartners Institute
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
Schizophrenia, Bipolar Disorder
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
The goal of this project, which has not changed, is to evaluate the statewide implementation of a two-component intervention (health promotion plus academic detailing) with respect to consumer outcomes and changes in provider…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT02334280
- Testing
- In SHAPE
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Gastrointestinal Cancer
Pathways to Advance Targeted and Helpful Serious Illness Conversations (PATH-SIC)
The purpose of this study is to increase serious illness conversations (SICs) about patients goals and preferences regarding their healthcare between patients with cancer and their oncology clinicians and improved care provided…
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Gynecologic Cancer, Thoracic Cancer
- Trial name
- (PATH-SIC) (NCT05629065)
- Testing
- Clinician Nudge Email, Patient Nudge Letter and Share questionaire
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Family Members of: Newborns Extremely Premature, Family Members of: New Pediatric Oncology Patients
Impact of Serious Pediatric Illness on Parent and Sibling Health
To estimate the impact of having a child with serious illness (SI) on the health and healthcare of other members of the child's family.
- Conditions
- Family Members of: Newborns Extremely Premature, Family Members of: New Pediatric Oncology Patients, Family Members of: Critical Congenital Heart Defect Patients, Family Members of: Children Severe Neurological Impairment
- Trial name
- NCT03971344
- Where
- United States
- Volunteers
- 161,000 people
- Sponsor
- Children's Hospital of Philadelphia
Schizophrenia, Bipolar Disorder
Skills Training to Enhance Vocational Outcomes in Veterans With Serious Mental Illness
Maintenance of employment is dependent upon being able to successfully integrate into one's work setting. This can present a significant challenge to individuals with serious mental illness, as they typically exhibit impairment…
- Conditions
- Schizophrenia, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT02663349
- Testing
- Social Cognition and Intervention Training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Chemotherapy
Effects of Frequent Decision Making Among Patients With Serious Illnesses
Decision making capacity fatigues after repeated decisions similar to skeletal muscle. The result is decision fatigue, in which subsequent decisions are altered toward the status quo.
- Trial name
- NCT01722123
- Testing
- Hypothetical scenarios and related decisions
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Pennsylvania
Advance Care Planning
Culturally Tailoring an Advance Care Planning Intervention for American Indians
This project has three specific aims: (1) culturally tailor the content of the Make Your Wishes about You (MY WAY) ACP curriculum and guide for one American Indian tribe; (2) assess the feasibility of the culturally-tailored MY…
- Trial name
- NCT05304117
- Testing
- Advance Care Planning
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Western Carolina University
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Alcoholism, Diagnosis, Dual (Psychiatry)
12-step Facilitation for the Dually Diagnosed
This is a randomized trial testing the efficacy of a modified 12-step facilitation therapy for individuals with serious mental illness and alcohol use disorders, compared to usual treatment.
- Trial name
- TSFDD (NCT00583440)
- Testing
- 12-step facilitation, Treatment as usual
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of New Mexico
Serious Mental Illness
Effectiveness and Cost Effectiveness of Peer Mentors in Reducing Hospital Use
The current study, through a randomized controlled design, will evaluate the effectiveness of peer support, as compared to usual care and to an equivalent amount of support offered by peer case managers and non-peer recovery…
- Trial name
- Project PEP (NCT01566513)
- Testing
- Community Connector, Peer Recovery Mentor, Peer Case Manager
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Yale University
Cigarette Smoking, Schizophrenia
Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness
The overall aim of this study is to test the effect of academic detailing (i.e. provider-level educational intervention focused on evidence-based smoking cessation treatment for those with psychiatric illness) and community…
- Conditions
- Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major
- Trial name
- NCT02845440
- Testing
- Academic Detailing, Community Health Worker, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 1,165 people
- Sponsor
- Massachusetts General Hospital
Mental Disorders, Severe
Physical Activity to Reduce Diabetes Risk in Serious Mental Illness
The aim of this project is to trial the protocol of a park-based physical activity (PA) intervention in adults with severe mental illness (SMI) in a community mental health center's peer support program.
- Trial name
- PARCS Pilot (NCT05293587)
- Testing
- Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Augusta University
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Schizophrenia, Depression
Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses
This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses.
- Conditions
- Schizophrenia, Depression, Bipolar Disorder, Anxiety Disorders
- Trial name
- NCT00458094
- Testing
- Physical activity intervention with peer support (PA+PS), Physical activity intervention without peer support (PA)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neoplasms, Pulmonary Disease, Chronic Obstructive
Outlook: An Intervention to Improve Quality of Life in Serious Illness
This study will demonstrate whether an end-of-life preparation and completion intervention reduces anxiety, depression, pain and other symptoms and improves functional status, spiritual well-being, and quality of life.
- Conditions
- Neoplasms, Pulmonary Disease, Chronic Obstructive, Heart Failure, Renal Disease
- Trial name
- NCT00939146
- Testing
- Outlook Attention Control, Outlook Intervention
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Duke University
HIV, Mental Illness
Nursing Intervention for HIV Regime Adherence Among People With Serious Mental Illness (SMI)
The purpose of this research study is to investigate how nurses can best help people with serious mental illnesses (SMI) follow their HIV treatment plans.
- Trial name
- NCT00264823
- Testing
- Use of Memory Aids to take medications
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- National Institute of Nursing Research (NINR)
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Depression, Bipolar Disorder
Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias Modification
Approximately 4.1% of the adult US population meets the criteria for SMI, a mental disorder associated with significant functional impairment.
- Conditions
- Depression, Bipolar Disorder, Anxiety Disorders, Psychiatric Disorder
- Trial name
- NCT03509181
- Testing
- I-Change, Symptom Tracking
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mclean Hospital
Mental Illness, Chronic Disease
Brief COVID-19 Intervention for People With Serious Mental Illness and Co-Morbid Medical Conditions
The study will enroll 600 people with serious mental illness who receive services at Centerstone in KY or TN and will compare two different evidence-based self-management interventions: Integrated Illness Management and Recovery…
- Trial name
- NCT05467982
- Testing
- Integrated Illness Management and Recovery, Chronic Disease Self-Management Program
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- Dartmouth-Hitchcock Medical Center