Clinical trials: Serious Illness, active
Depression, Cancer
Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)
The purpose of this study is to develop and test a new intervention to reduce depressive symptoms in post-treatment cancer participants.
- Conditions
- Depression, Cancer, Stage III Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT06811454
- Testing
- MINDSET, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Case Comprehensive Cancer Center
Serious Mental Illness, Schizophrenia
Mindfulness-Based Therapy for Serious Mental Illness
Serious mental illness (SMI), encompassing schizophrenia-spectrum and major mood disorders, has been estimated to affect approximately 5.4% of the U.S. adult population each year.
- Conditions
- Serious Mental Illness, Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- MBT (NCT06880796)
- Testing
- Mindfulness-based therapy, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Butler Hospital
Repetitive Negative Thinking, Neurofeedback
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents…
- Trial name
- CHARMS (NCT07055217)
- Testing
- Mindfulness Training, Mindfulness-based Neurofeedback (Real mbNF)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Serious Mental Illness, Type 2 Diabetes
MetSense Pilot and Feasibility
People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions.
- Trial name
- MetSenseP&F (NCT07264062)
- Testing
- MetSense Risk Flag, Usual Care
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Kaiser Permanente
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Schizophenia Disorder, Schizoaffective Disorder
Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness (R33)
This randomized clinical trial will test a new technology-supported blended intervention, mobile Social Interaction Therapy by Exposure (mSITE), that targets social engagement in consumers with serious mental illness.
- Trial name
- NCT06865937
- Testing
- Mobile Intervention for Social Recovery in Serious Mental Illness (mSITE), Supportive Contact (SC)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Diego
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Malnutrition, Infant, Breastfeeding, Exclusive
Providing Breastfeeding Support After Discharge From Hospital to Improve Growth and Development of Malnourished Infants
The current guidelines used to manage malnutrition among infants aged below 6 months (u6m) recommend that infants admitted to hospital with malnutrition be supported to reestablish exclusive breastfeeding before discharge.
- Trial name
- IBAMI-2 (NCT06372418)
- Testing
- Breastfeeding peer support intervention, Standard Care
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Diabetic Foot Ulcer (DFU), Palliative Care
The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care
The ProActive study aims to investigate the feasibility of integrating a proactive palliative care approach into routine care for people with diabetic foot ulcers (DFU).
- Conditions
- Diabetic Foot Ulcer (DFU), Palliative Care, Advance Care Planning
- Trial name
- NCT07781111
- Volunteers
- 484 people
- Sponsor
- Ulla Riis Madsen
Documentation of Serious Illness Communication for Critically Ill Patients
Pilot Trial of Ambient Listening for Intensive Care Unit Family Meeting Summaries
The goal of this clinical trial is to learn whether ambient listening can help healthcare providers create written summaries of conversations with the families of patients in the medical intensive care unit (ICU).
- Trial name
- PALMS (NCT07915908)
- Testing
- Receipt of ambient listening-generated draft clinical note
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Breast Cancer, Gastrointestinal Cancer
Pathways to Advance Targeted and Helpful Serious Illness Conversations (PATH-SIC)
The purpose of this study is to increase serious illness conversations (SICs) about patients goals and preferences regarding their healthcare between patients with cancer and their oncology clinicians and improved care provided…
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Gynecologic Cancer, Thoracic Cancer
- Trial name
- (PATH-SIC) (NCT05629065)
- Testing
- Clinician Nudge Email, Patient Nudge Letter and Share questionaire
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Serious Mental Illness, Tobacco Use Disorder
Facilitation to Increase Tobacco Treatment
Smoking disproportionally impacts Veterans, and VA spends $2.7 billion annually on smoking-related health conditions. Veterans with serious mental illness (SMI) smoke tobacco products at triple the rate of Veterans without any…
- Trial name
- FITT (NCT07455526)
- Testing
- Multi-component facilitation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Palliative Care, Advanced Cancer
Coaching in Palliative Surgical Oncology
This study aims to evaluate the effectiveness of a serious illness coaching intervention (CONCORD) in improving quality of serious illness conversation (SIC), treatment decision-making, goal-concordant care delivery and quality…
- Trial name
- NCT07789093
- Testing
- CONCORD coaching intervention
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- Singapore General Hospital
Cigarette Smoking
E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
In this open-label, randomized controlled trial study, participants who smoke combustible cigarettes (CC) and are diagnosed with Serious Mental Illness (SMI) will be randomized in two arms to receive harm-reduction counseling and…
- Trial name
- NCT05815199
- Testing
- E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Schizophrenia Spectrum Disorders, Psychotic Affective Disorders
MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI
This study aims to test the feasibility and acceptability of a brief behavioral intervention that combines two treatments, Motivational Interviewing (MI) and Cognitive Behavioral Therapy (CBT), that have been shown to work in…
- Conditions
- Schizophrenia Spectrum Disorders, Psychotic Affective Disorders, Psychotic Mood Disorders, Homelessness
- Trial name
- NCT06138054
- Testing
- MI-CBTech, Mindfulness control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Demoralization
Pragmatic Trial of Psilocybin Therapy in Palliative Care
This multicenter, triple-blind, phase 2, randomized controlled trial will evaluate the efficacy and safety of psilocybin therapy compared to an active control in treating demoralization in adults near the end of life (≤2 years…
- Trial name
- PT2PC (NCT05403086)
- Testing
- Psilocybin, Ketamine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Charles S. Grob, M.D.
Schizophrenia, Bipolar Disorder
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Many individuals with serious mental illness have difficulty accurately interpreting interpersonal cues and effectively engaging in social exchanges.
- Conditions
- Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Stress Disorder, Post-Traumatic
- Trial name
- NCT05491538
- Testing
- Social Cognition and Interaction Training-Work Edition (SCIT-WE)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Type 1 Diabetes, Asthma
EmoTIChealth: Promoting Adolescent Health Through a Serious Game.
The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong…
- Conditions
- Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy
- Trial name
- NCT07212530
- Testing
- EmoTIChealth
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Care Transitions
Improving Care Transitions for Medicaid Insured Individuals With Co-occurring Serious Mental Illness
This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization.
- Trial name
- THRIVE-SMI (NCT06203509)
- Testing
- Thrive Intervention
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania