Clinical trials: Serum Biomarkers
COPD Exacerbation
Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB)
40 outpatients with exacerbations of Chronic Obstructive Pulmonary Diseases (COPD) will be enrolled in a multi-centre, open-label, randomised, pilot study.
- Trial name
- NCT01467297
- Testing
- ceftidoren, levofloxacin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Crohn's Disease
Efficacy and Safety Trial of RPC1063 for Moderate to Severe Crohn's Disease
The purpose is to determine whether RPC1063 is effective in the treatment of Crohn's disease.
- Trial name
- NCT02531113
- Testing
- RPC1063
- Where
- 28 sites in United States, Canada and 3 more
- Volunteers
- 69 people
- Sponsor
- Celgene
S100A8, Serum
S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis
This study aims to evaluate both serum and urine S100A8 as potential biomarkers for Lupus nephritis (LN)
- Conditions
- S100A8, Serum, Urine, Biomarker
- Trial name
- NCT06872138
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Major Depression
Serum Markers as a Bioassay for Unipolar Depression
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response.
- Trial name
- NCT00825799
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Lung Cancer, Non-small Cell Lung Cancer Stage I
Volatolomic and Proteomic Profile for Early Diagnosis of Lung Cancer
The goal of this prospective, case-control study is to discover the specific "omics" biomarkers of early stage of lung cancer using the non-invasive samples (breath, urine and serum) in a total of 200 subjects (100 healthy…
- Conditions
- Lung Cancer, Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II, Lung Cancer Diagnosis
- Trial name
- NCT06341387
- Testing
- Breath, urine and blood analysis
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Ailesel Akdeniz Ateşi
"Galectin-3 as a Marker of Subclinical Inflammation in FMF"
The goal of this observational study is to learn about the relationship between serum Galectin-3 levels and subclinical inflammation in patients with Familial Mediterranean Fever (FMF).
- Trial name
- NCT06451471
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Turkish League Against Rheumatism
Cardiac Arrest
Prognostication Biomarkers in Pediatric Cardiac Arrest
This multicenter study will validate a panel of serum, imaging, and clinical biomarkers to classify patient outcome early after out-of-hospital pediatric cardiac arrest.
- Trial name
- NCT02769026
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pittsburgh
Leukemia, Lymphoma
Serum Histone Succinylation as a Novel Prognostic Biomarker in Hematological Malignancies
4. Study Population 4.1 Inclusion Criteria Case group 1)≥ 18 years old , regardless of gender; 2)Hematological malignancies confirmed by cytology, histology , or molecular biology , who require subsequent anti-tumor treatment …
- Trial name
- succinylation (NCT07131449)
- Testing
- This is observational studies, participants are not assigned an intervention as part of the study.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Interstitial Lung Disease, Desquamative
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Interstitial lung disease is a chronic progressive fibrosis lung disease that with a highly variable clinical process.thence it is significant for the patient to search a convenient and accurate prediction method.
- Trial name
- NCT02960672
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Effects of Immunotherapy
Serum MicroRNAs 223 and 146a in Allergic Rhinitis Patients as Biomarkers for Efficacy of Sublingual Immunotherapy
The aim of the study is: to evaluate the serum levels of miR-223 and miRNA146a and to assess their correlation with disease severity in allergic rhinitis patients and their role as biomarkers for efficacy of sublingual…
- Trial name
- NCT04813380
- Testing
- Sublingual immunotherapy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Zagazig University
Preterm Delivery
Preterm Delivery Risk Prediction by Measurement of Prenatal Serum Screening Markers
This protocol seeks to longitudinally collect blood samples from a cohort of pregnant women. The biological specimens will be used to determine the predictive power of biochemical markers routinely used in Down syndrome screening…
- Trial name
- NCT01009723
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Esoterix Genetic Laboratories, LLC
Breast Cancer Survivors
Impact of COX2 on Sera Biomarkers From Obese Subjects
Obesity promotes worse outcome for post-menopausal breast cancer patients.
- Trial name
- NCT02062255
- Testing
- Aspirin, Omega 3 FFA
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Allergic Rhinitis (AR)
EFFECT OF AYURVEDA TREATMENT IN ALLERGIC RHINITIS
Background Allergic Rhinitis is a chronic Th2-mediated inflammatory disorder associated with significant disease burden and impaired quality of life.
- Trial name
- ARAM (NCT07626099)
- Testing
- AYURVEDA treatment protocol, Control(Citrizine 10mg)
- Volunteers
- 104 people
- Sponsor
- Amrita Vishwa Vidyapeetham
Delirium
Predicting the Risk of Post-operative Delirium: Use of Neuropsychology, Serum and CSF Biomarkers and Genetics to Predict Risk of Post-operative Delirium
The purpose of the study is to determine if pre-operative neuropsychological characteristics, apolipoprotein E4 status and/or cerebrospinal fluid (CSF) and serum biomarkers can predict those most at risk of post-operative…
- Trial name
- NCT02299037
- Where
- United Kingdom
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Pregnancy, Ectopic
Serum VEGF as a Tubal Pregnancy Marker
The aim of the present study was (i) to evaluate whether a single measurement of VEGF would allow us to distinguish between intrauterine pregnancy (normal and abnormal) and EP and (ii) to correlate the levels of VEGF with serum…
- Trial name
- NCT02973230
- Testing
- Dosage of VEGF serum concentration
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Vitamin D Deficiency, Vitamin D Insufficiency
ALPCO 25(OH) Vitamin D CLIA Kit - Fresh Versus Frozen Serum and Plasma Stability Study
This study evaluates the stability of 25-hydroxyvitamin D [25(OH)D] measurements in human serum and plasma using the ALPCO 25(OH) Vitamin D CLIA Kit.
- Conditions
- Vitamin D Deficiency, Vitamin D Insufficiency, Healthy Volunteers
- Trial name
- NCT07565064
- Testing
- ALPCO 25(OH) Vitamin D CLIA Kit
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Muscular Dystrophies, Becker Muscular Dystrophy
Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies
Duchenne muscular dystrophy (DMD) , caused by mutations in the DMD gene, is the most common and most severe progressive dystrophy of the child.
- Conditions
- Muscular Dystrophies, Becker Muscular Dystrophy, Duchenne Muscular Dystrophy
- Trial name
- biodystromirs (NCT02109692)
- Testing
- blood sample
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related
Melatonin Levels on COVID-19 Positive Pregnant Women
This study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe COVID-19 infection in pregnant women.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
- Trial name
- NCT05318144
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Nazan Yurtcu MD
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Biomarkers
Metabolomics Profiling of Coronary Heart Disease
This study sought to assess the diagnostic and prognostic values of metabolomics in coronary artery disease(CAD).
- Trial name
- NCT05138731
- Testing
- treatments according guidelines
- Where
- 5 sites in China
- Volunteers
- 821 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University