Clinical trials: Severe ARDS
Respiratory Distress Syndrome, Adult
A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS
A Phase 1 study of agenT-797 to treat moderate to severe acute respiratory syndrome in Coronavirus disease 2019 (COVID-19) participants.
- Trial name
- NCT04582201
- Testing
- agenT-797
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- MiNK Therapeutics
COVID-19
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients.
- Trial name
- I-SPY_COVID (NCT04488081)
- Testing
- Remdesivir, Imatinib Mesylate, Dexamethasone
- Where
- 36 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- QuantumLeap Healthcare Collaborative
Severe Acute Respiratory Syndrome (SARS) Pneumonia, Coronavirus Infections
Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome
COVID-19 infection is overwhelming Italian healthcare. There is an urgent need for a solution to the lack of ICU beds and increasing deaths day after day.
- Conditions
- Severe Acute Respiratory Syndrome (SARS) Pneumonia, Coronavirus Infections, ARDS, Human
- Trial name
- MP-C19 (NCT04323592)
- Testing
- Methylprednisolone, standard care
- Where
- Italy
- Volunteers
- 173 people
- Sponsor
- University of Trieste
COVID-19 Infection
Neurological and Neuropsychological Sequelae of COVID-19 Infection
COVID-19 is known to affect the respiratory system but may also have an impact on other organ systems, including the brain. A number of severely ill patients also presents neurological symptoms that may be the result of COVID-19…
- Trial name
- NeNeSCo (NCT04745611)
- Testing
- MRI, Neuropsychological assessment, Questionnaires Patient
- Where
- 3 sites in Netherlands
- Volunteers
- 329 people
- Sponsor
- Maastricht University
COVID-19 Pneumonia, ARDS Due to Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Plasma SARS-CoV-2 RNA Levels in Critically Ill COVID-19 Patients
Retrospective, observationnal study. Evaluation of the association between plasmatic SARS-CoV-2 RNA and day 60 mortality in ICU adult COVID-19 patients.
- Trial name
- pRNA-COVID-ICU (NCT05115045)
- Testing
- plasmatic SARS-CoV-2 RNA quantification
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Hopital of Melun
Acute Respiratory Distress Syndrome (ARDS)
Early EIT-Guided PEEP Titration on Pulmonary Physiology in Patients With Moderate-to-Severe ARDS Undergoing Prone Positioning (EIT-PEEP-PRONE)
Background: Electrical impedance tomography (EIT)-guided PEEP titration has been shown to improve regional ventilation distribution, increase respiratory system compliance, and reduce mechanical power in patients with acute…
- Trial name
- EIT-PEEP-PRONE (NCT07793565)
- Testing
- EIT-Guided PEEP Titration Group, ARDSNet/PEEP-FiO₂ Table
- Where
- China
- Volunteers
- 40 people
- Sponsor
- XIE MIN
Acute Respiratory Distress Syndrome
Effectiveness of Convalescent Immune Plasma Therapy
The aim of the study is to evaluate the safety, improvement of clinical symptoms and laboratory parameters of convalescent immune plasma treatment in severe Covid-19 patients with ARDS.
- Trial name
- NCT04442958
- Testing
- Convalescent Immune Plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bagcilar Training and Research Hospital
Covid19
A Phase II Study in Patients With Moderate to Severe ARDS Due to COVID-19
This is a Phase II multi-center, double-blind, placebo-controlled, randomized study in Patients with moderate to severe lung injury due to COVID-19 or other potential viral and bacterial pathogens.
- Trial name
- NCT04780685
- Testing
- hMSC
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Stemedica Cell Technologies, Inc.
Covid19, SARS-CoV Infection
Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?
SARS-CoV-2 is a member of a class of viruses: angiotensin converting enzyme 2 (ACE2)-binding viruses that study calls "ABVs". The World Health Organization (WHO) and others are performing randomized controlled trials (RCTs) of…
- Trial name
- ARBs CORONA II (NCT04606563)
- Testing
- Losartan, Valsartan, Azilsartan
- Where
- 13 sites in Canada, France
- Volunteers
- 341 people
- Sponsor
- University of British Columbia
Acue Respiratory Distress Syndrome
Use of Extracorporeal CO2 Removal in Case of Moderate to Severe ARDS to Apply an Ultraprotective Mechanical Ventilation Strategy
The extracorporeal CO2 removal (ECCO2R) has been recently proposed in case of Acute Respiratory Distress Syndrome (ARDS) in order to reduce pulmonary injuries induced by the mechanical ventilation.
- Trial name
- ECCO2R (NCT04556578)
- Testing
- High-flow extracorporeal CO2 removal
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Montpellier
ARDS (Moderate or Severe)
Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics
- Trial name
- PRONEBRAINAR (NCT06967285)
- Testing
- Prone ventilation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sichuan Provincial People's Hospital
Multiple Trauma, Respiratory Distress Syndrome, Adult
Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma
Severe hypoxemia following trauma may happen in many circumstances (aspiration, ventilation-associated pneumonia, lung contusion...), most of which are not exclusively associated with a direct injury to the lungs.
- Trial name
- TRAUMADORNASE (NCT03368092)
- Testing
- Dornase Alfa Inhalant Solution [Pulmozyme]
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related
Melatonin Levels on COVID-19 Positive Pregnant Women
This study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe COVID-19 infection in pregnant women.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
- Trial name
- NCT05318144
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Nazan Yurtcu MD
COVID19 ARDS
Efficacy of Infusions of MSC From Wharton Jelly in the SARS-Cov-2 (COVID-19) Related Acute Respiratory Distress Syndrome
Mesenchymal stem cells (MSCs) are of potential help in acute respiratory distress syndrome (ARDS), due to their anti-inflammatory properties.
- Trial name
- MSC-COVID19 (NCT04625738)
- Testing
- Ex vivo expanded Wharton's Jelly Mesenchymal Stem Cells
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
ARDS (Acute Respiratory Distress Syndrome), VV ECMO
Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS
The purpose of this study is to find a better way to protect the lungs of patients with Acute Respiratory Distress Syndrome (ARDS) who are being treated with a mechanical ventilator in addition to an extracorporeal membrane…
- Trial name
- PROTECT-ARDS (NCT07790133)
- Testing
- Mechanical Power Targeted Ventilation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Acute Respiratory Distress Syndrome, Infections
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS…
- Trial name
- NCT05947955
- Testing
- Rhu-pGSN, normal saline
- Where
- 65 sites in United States, Belgium and 11 more
- Volunteers
- 600 people
- Sponsor
- BioAegis Therapeutics Inc.
Critically Ill Patients Admitted in ICU
Severe Hypoxemia : Prevalence, Treatment and Outcome
Hypoxemia is usually observed during ICU stay. Nevertheless, the prevalence of hypoxemia among patients admitted in ICU is not well known, in partly due to a lack of a consensual definition.
- Trial name
- NCT02722031
- Where
- France
- Volunteers
- 1,694 people
- Sponsor
- French Society for Intensive Care
ARDS, Mechanical Power
Ventilatory Parameters in Predicting Outcomes in ARDS Patients
This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes…
- Trial name
- OCTANE (NCT06400095)
- Testing
- Poccl, Time constant, driving pressure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- CentraCare
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Respiratory Distress Syndrome
Place of ECMO in the Management of Severe Refractory ARDS Associated With Covid-19
Describe COVID-19 patients who are receiving ECMO-VV respiratory replacement and what happens to them.
- Trial name
- ECMO-COVID-19 (NCT04343404)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France