Clinical trials: Severe Acute Respiratory Syndrome
COVID-19
A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients
The primary purpose of Stage-I of this study is to evaluate the safety and tolerability of OP-101 in patients with severe COVID-19 and of Stage 2 of this study is to evaluate the efficacy of OP-101 in patients with severe…
- Trial name
- PRANA (NCT04458298)
- Testing
- OP-101
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Ashvattha Therapeutics, Inc.
SARS-CoV2 Infection
The Efficacy of Vitamin D Supplementation in Patients With Severe and Extremely Severe COVID-19
Despite the successful treatment of patients with moderate coronavirus disease 2019 (COVID-19), outcomes for patients with severe disease remain unsatisfactory.
- Trial name
- COVID-VIT (NCT05092698)
- Testing
- Vitamin D (cholecalciferol), Herbal oil
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Covid19, Infertility, Male
Impact of the Coronavirus Disease 2019 (COVID-19) on Sperm Parameters
This study aims to better understand the effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virus that causes the coronavirus disease 2019 (COVID-19), on male fertility.
- Trial name
- NCT04937608
- Testing
- Sperm analysis
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Fertilys
Covid19, SARS-CoV Infection
Prognostic Value of Flow-mediated Dilation in Hospitalized COVID-19 Patients
This study will evaluate the associations between vascular parameters and clinical outcomes in patients hospitalized with COVID-19.
- Trial name
- NCT04714125
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Distress Syndrome, Adult
ARDSnet Protocol vs. Open Lung Approach in ARDS
Many patients with Acute Respiratory Distress Syndrome or ARDS need breathing support that is provided by a machine called a ventilator or respirator.
- Trial name
- NCT00431158
- Testing
- Different Mechanical Ventilation Protocols
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Massachusetts General Hospital
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center
Covid19, SARS (Severe Acute Respiratory Syndrome)
Prophylaxis Covid-19 in Healthcare Agents by Intensive Treatment With Ivermectin and Iota-carrageenan
IMPORTANCE: The emergency of COVID-19 requires the implementation of urgent strategies to prevent the spread of the disease, mainly in health personnel, who are the most exposed and has the highest risk of becoming infected with…
- Trial name
- Ivercar-Tuc (NCT04701710)
- Testing
- Ivermectin / Iota-Carrageenan
- Where
- Argentina
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maria de los Angeles Peral de Bruno
Covid-19
Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm
This is a Phase II pilot exploratory study designed to investigate if prophylactic treatment with short term steroids administered to high risk Covid-19 patient might prevent cytokine storm and progression to respiratory failure.
- Trial name
- NCT04355247
- Testing
- MethylPREDNISolone 80 Mg/mL Injectable Suspension
- Where
- 2 sites in Puerto Rico
- Volunteers
- 20 people
- Sponsor
- Auxilio Mutuo Cancer Center
ARDS, Human, COVID
Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency
SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease that has now been named COVID-19.
- Trial name
- COVIPOC (NCT04594668)
- Testing
- Senicapoc
- Where
- 4 sites in Denmark
- Volunteers
- 46 people
- Sponsor
- University of Aarhus
SARS-CoV Infection
Nitric Oxide Releasing Solution to Treat and Prevent Exacerbation of Mild COVID-19 Infection
This is a double-blinded, placebo-controlled parallel, phase II clinical efficacy study evaluating Nitric Oxide Nasal Irrigation (NONI) for the treatment of COVID-19 in individuals with mild COVID-19 Infection.
- Trial name
- NCT04443868
- Testing
- Nitric Oxide-Releasing Drug
- Sponsor
- Sanotize Research and Development corp.
Healthy Volunteers
A Trial to Learn if Different Doses of REGN17092 Are Safe in Healthy Adults
The purpose of this study is to learn about the safety and tolerability of different doses of REGN17092 administered with a needle either under the skin (called "subcutaneous") or into a vein (called an "infusion") in healthy…
- Trial name
- NCT05923424
- Testing
- REGN17092
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Coronavirus, Coronavirus Infection
Observational Study of COVID-19 Treatment Efficacy
To compare various treatments provided to positive COVID-19 patients at locations across the OSF Ministry. Provide the opportunity to compare the effectiveness of various treatments and treatment timelines provided to specific…
- Conditions
- Coronavirus, Coronavirus Infection, Corona Virus Infection, COVID
- Trial name
- NCT04369989
- Testing
- No intervention
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- OSF Healthcare System
Covid19, Coronavirus Infection
Randomized Phase IIA Clinical Trial to Evaluate the Efficacy of Ivermectin to Obtain Negative PCR Results in Patients With Early Phase COVID-19
SAINT-PERU is a triple-blinded, randomized placebo-controlled trial with two parallel arms to evaluate the efficacy of ivermectin in negativizing nasopharyngeal PCR in patients with SARS-CoV-2 infection.
- Conditions
- Covid19, Coronavirus Infection, SARS-CoV Infection
- Trial name
- SAINT-PERU (NCT04635943)
- Testing
- Ivermectin
- Where
- Peru
- Volunteers
- 186 people
- Sponsor
- Universidad Peruana Cayetano Heredia