Clinical trials: Severe Brain Injury
Traumatic Brain Injury
Antisecretory Factor In Severe Traumatic Brain Injury
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury.
- Trial name
- AFISTBI (NCT04117672)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Traumatic Brain Injury
Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Each year in the United States alone, a third of a million persons are hospitalized for traumatic brain injury (TBI), of whom approximately 1/4 die. Most are less than 30 years of age.
- Trial name
- RESCUE-TBI (NCT00973674)
- Testing
- Premarin IV
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Brain Injury Traumatic Severe
Severe Head Injury Brain Analysis
Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken.
- Trial name
- SHIBA (NCT05206760)
- Testing
- Brain biopsy
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Queen Mary University of London
Traumatic Brain Injury
Study of Reserves After Traumatic Brain Injury
It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves.
- Trial name
- NCT01628003
- Testing
- Brain MRI, MRI
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Traumatic Brain INjury
Prognostic Potential of Prehospital Biomarkers in TBI Patients
The PreTBI III study aims to investigate the prognostic potential of prehospital and repeated in-hospital S100B, NSE and GFAP measurements as predictors of neurological outcome in patients suffering severe TBI.
- Trial name
- PreTBI III (NCT03062566)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Aarhus
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury
Dexanabinol in Severe Traumatic Brain Injury
Each year a large number of patients are hospitalized at Shock Trauma Centers with severe head injuries. Bleeding into and swelling of these patients' brains may cause compression of vital structures, disability and death.
- Trial name
- NCT00129857
- Testing
- Dexanabinol
- Volunteers
- 860 people
- Sponsor
- Pharmos
Traumatic Brain Injury
Cerebral Oxygenation and Metabolism and Severe Head Injury in Paediatrics (COMetSHIP)
Children suffer proportionally more head injuries than any other age group and children with head injuries have the highest mortality of all children admitted with traumatic injuries.
- Trial name
- COMetSHIP (NCT05717647)
- Testing
- Observational study: neuromonitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Posttraumatic Stress Disorder (PTSD), Depression - Major Depressive Disorder
To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Magnetic Stimulation Therapy for Patients With Post-traumatic Stress Disorder Comorbid Major Depressive Disorder
This study aims to investigate the immediate neurophysiological and autonomic effects of two noninvasive brain stimulation protocols-prolonged intermittent theta-burst stimulation (prolonged iTBS) and high-frequency repetitive…
- Trial name
- NCT07327385
- Testing
- Prolonged Intermittent Theta-Burst Stimulation (prolonged iTBS), High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Major Depressive Disorder, Traumatic Brain Injury
fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI
This pilot study aims to investigate the efficacy of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in treatment of major depression associated with traumatic brain injury (TBI).
- Trial name
- NCT02980484
- Testing
- Active
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Brain Injuries, Traumatic
Brain Oxygen Optimization in Severe TBI, Phase 3
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU).
- Trial name
- BOOST3 (NCT03754114)
- Testing
- ICP + PbtO2 guided management strategy, ICP guided management strategy
- Where
- 51 sites in United States, Canada
- Volunteers
- 1,094 people
- Sponsor
- University of Michigan
Quality of Life, Brain Injuries
Withholding of Life-sustaining Treatment and Quality of Life After Severe Acute Brain Injury: Qualitative Analysis and Ethical Issues
Withdrawal of life-sustaining treatment affects 10-15% of ICU patients, including those with severe acute brain injury, whose care appears futile in terms of prognosis based on clinical and paraclinical data, expected quality of…
- Conditions
- Quality of Life, Brain Injuries, Post ICU
- Trial name
- NCT06523127
- Testing
- Recording data from the ICU stay and the post-ICU follow-up.
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Severe Traumatic Brain Injury With High Cerebral Pressure
Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury
Severe traumatic brain injury with increased intracranial pressure can lead to decreased cerebral blood flow. Low cerebral blood flow is responsible for secondary lesions, leading to bad prognosis.
- Trial name
- DEBITC (NCT02019810)
- Testing
- Norepinephrine, Dobutamine and norepinephrine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury, Neurodegenerative Diseases
Long-term Follow-up in Severe Traumatic Brain Injury
The underlying pathophysiology following traumatic brain injury (TBI) in how different neurodegenerative conditions are developed are still unknown. Different neuroinflammatory and neurodegenerative pathways have been suggested.
- Conditions
- Traumatic Brain Injury, Neurodegenerative Diseases, Chronic Traumatic Encephalopathy
- Trial name
- LONG-TBI (NCT05235802)
- Testing
- Magnetic Resonance Imaging (MRI) (including functional MRI), Blood sampling (serum/plasma preparation), Cerebrospinal fluid (CSF)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Efficacy of Pharmacological Treatment of Working Memory Impairment After Traumatic Brain Injury: Evaluation With fMRI
This study is designed to examine the effects of a wake-promoting agent (Modafinil) on working memory (WM) in persons with moderate to severe TBI utilizing a double blinded placebo controlled methodology.
- Trial name
- NCT00489892
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Brain Injuries
Efficiency of Coupling Targeted Temperature Management to Brain Temperature in Severe Brain Injury
In severe brain-injured patients, it is recommended to strictly control the fever in order to limit brain damage (objective of neuroprotection) via the targeted temperature management (TTM).
- Trial name
- BRAINTTM (NCT03967626)
- Testing
- external cooling with the xxxxx device
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Pituitary Disorders, Traumatic Brain Injury
The PIT-TBI Pilot Study
Damage to the pituitary gland is a frequently overlooked but potentially important complication of traumatic brain injury (TBI). Disorders of the pituitary gland can cause dysfunction of the thyroid, adrenals, ovaries and testes.
- Trial name
- NCT02480985
- Testing
- Pituitary function evaluation
- Where
- 5 sites in Canada
- Volunteers
- 70 people
- Sponsor
- CHU de Quebec-Universite Laval
Trauma, Brain
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive…
- Trial name
- CG-Well (NCT05307640)
- Testing
- CG-Well, Information Support & Referral (ISR)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Natalie Kreitzer
Healthy, Posttraumatic Stress Disorder
Brain Function in Mentally Ill Adolescents
The purpose of this study is to use brain imaging technology to examine the brain activity of adolescents with post-traumatic stress disorder (PTSD) and/or major depressive disorder (MDD) before and after treatment.
- Conditions
- Healthy, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025857
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- National Institute of Mental Health (NIMH)