Clinical trials: Severe Brain Injury
Cerebral Palsy, Arthrogryposis
Effects of Power Mobility on Young Children With Severe Motor Impairments
The purpose this study is to determine the effects of power mobility on the development and function of young children of young children whose severe physical disabilities limit their exploratory behaviors and may unnecessarily…
- Conditions
- Cerebral Palsy, Arthrogryposis, Spinal Muscular Atrophy, Other Central Nervous System or Musculoskeletal Disorders
- Trial name
- NCT01028833
- Testing
- Power mobility
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma
Brain Injury Traumatic Diffuse With Loss of Consciousness
Clinical Analysis of Early Hormones Between Patients With Traumatic Brain Injury and Cerebral Hemorrhage
Our understanding of neurosecretory dysfunction after TBI is still insufficient, and the number of patients with neuroendocrine dysfunction caused by craniocerebral trauma may be underestimated, especially the neuroendocrine…
- Trial name
- NCT06221215
- Testing
- trauma
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
OCTA, Severe Brain Injury
Effect of the Stellate Ganglion Block on the Retinal Microcirculation
Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke.
- Conditions
- OCTA, Severe Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT06797752
- Testing
- OCTA Scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury
Traumatic Neuroprotection and Epilepsy Prevention of Valproate Acid
1. Background: Preliminary studies have suggested that valproate acid (VPA) may promote neuron survival, inhibit apoptosis, decrease the neuron function deficit in cerebral ischemia, and promote the brain functional recovery…
- Trial name
- VPA (NCT02027987)
- Testing
- valproate acid
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xijing Hospital
Depression
Antidepressant Maintenance in Traumatic Brain Injury
The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with…
- Trial name
- NCT00162916
- Testing
- citalopram
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ontario Neurotrauma Foundation
Disorders of Consciousness Due to Severe Brain Injury
the Prediction Value of Combined Electroencephalographic and Electromyographic Response in Disorders of Consciousness
The goal of this observation study is to learn about the prediction value of combined electroencephalographic and electromyographic response in disorders of consciousness. The main ways of stimulation is thermal and itch.
- Trial name
- NCT06922864
- Testing
- thermal stimulation, itch
- Volunteers
- 36 people
- Sponsor
- KY20242235jiangwen
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Traumatic Brain Injury
Beyond One Option for the Treatment of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a public health issue with great disparity among low- and middle-income countries where the implementation of evidence-based guidelines is challenging because resources are often…
- Trial name
- BOOTStraP (NCT06787040)
- Testing
- Resource-Stratified Protocol
- Where
- 3 sites in Colombia
- Volunteers
- 96 people
- Sponsor
- Meditech Foundation
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Disorders of Consciousness Due to Severe Brain Injury
Peripheral Nerve Stimulation for Prognostic and Diagnostic Biomarker Identification in Disorders of Consciousness
This observational study aims to integrate anamnestic, clinical, and innovative neurophysiological data to assess their impact on the diagnosis and prognosis of patients with Disorders of Consciousness.
- Trial name
- MICRO-DOC (NCT06845800)
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Exercise, Cerebral Palsy
RaceRunning for Young People With Moderate-to-severe Cerebral Palsy
Physical inactivity in people with cerebral palsy (CP) has been linked with increased risk of cardiometabolic disease. Exercise studies rarely include people with CP with severe walking impairments and assess the sustainability…
- Trial name
- NCT04034342
- Testing
- RaceRunning
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Queen Margaret University
Depression, Closed Head Injury
TMS in the Treatment of the Sequelae of Closed Brain Injury
Depression is very common in people who have experienced a traumatic brain injury. Few treatments have been found to be effective in treating depression in this situation.
- Trial name
- NCT00531258
- Testing
- rTMS
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- Bayside Health
Trauma, Brain
PRECISION-TBI - An Observational Study of Patients With Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a devastating condition and a leading cause of long-term disability. Every patient with TBI has a different type of injury and is treated differently from hospital to hospital making it very…
- Trial name
- NCT05855252
- Testing
- No intervention
- Where
- 9 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Autism Spectrum Disorder, Traumatic Brain Injury
Using Virtual Reality and Robotics Technologies for Vocational Evaluation, Training and Placement
Using Virtual Reality and Robotics Technologies for Vocational Evaluation, Training and Placement (VR4VR) is a project that incorporates Virtual Reality into job training to increase job opportunities for people who have physical…
- Trial name
- VR4VR (NCT02498262)
- Testing
- Virtual Reality System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Disorders of Consciousness
Intensive Neurowave Emotional Stimulation (INES)
This is a randomized and controlled pilot study investigating the effects of intensive emotional stimulation with neurological waves (INES) on cognitive-motor functions in patients diagnosed with Vegetative State (VS) and…
- Trial name
- INES_ABI (NCT06204172)
- Testing
- Intensive Neurowave Emotional Stimulation (INES), Intensive Sensorial Emotional Stimulation (ISES)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Major Depression, Anxiety Disorder
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression
A pilot study to evaluate the ability of photobiomodulation to alter cerebral blood flow in the frontal poles and to affect the emotional status of patients with major depression.
- Conditions
- Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
- Trial name
- NCT00961454
- Testing
- Photobiomodulation with a super-luminous light emitting diode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Consciousness Disorders, Brain Injuries
Thalamic Low Intensity Focused Ultrasound in Brain Injury
Few neurological conditions are as scientifically mysterious and clinically, legally, and ethically challenging as disorders of consciousness.
- Trial name
- LIFUP (NCT02522429)
- Testing
- Low Intensity Focused Ultrasound Device
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Los Angeles
Diffuse Brain Injury
Trial Estimating the Efficiency of the Light Therapy in Brain Trauma Sequel Fatigue
After a brain injury (BI) , patients complain in particular about sequel fatigue. This symptom affects about 50 % of the patients; it is severe, with a repercussion on quality of life, reeducation and occupational reintegration…
- Trial name
- phototrauma (NCT02420275)
- Testing
- "Luminette",Lucimed Belgium
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Traumatic Brain Injury, Multiple Trauma
Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases.
- Trial name
- BBAX (NCT03965611)
- Testing
- Oropharyngeal swab, Rectal swab, Disability rating scale (DRS-F)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Posttraumatic Stress Disorder
Brain Function in Mentally Ill Adolescents
The purpose of this study is to use brain imaging technology to examine the brain activity of adolescents with post-traumatic stress disorder (PTSD) and/or major depressive disorder (MDD) before and after treatment.
- Conditions
- Healthy, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025857
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- National Institute of Mental Health (NIMH)