Clinical trials: Severe Brain Injury
Severe Traumatic Brain Injury
Study of the Safety and Efficacy of Conivaptan (Vaprisol®) to Raise Serum Sodium Levels in Patients With Severe Traumatic Brain Injury
The investigators plan to utilize conivaptan (Vaprisol) to promote isolated water loss, in combination with normal (physiologic) fluid replacement to maintain a normal blood volume status, in patients with severe TBI.
- Trial name
- NCT00930202
- Testing
- Conivaptan (Vaprisol)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Traumatic Brain Injury
Effects of Huperzine A in Treatment of Moderate to Severe TBI
We will explore the use of Huperzine A in patients who have sustained a moderate to severe Traumatic Brain Injury. We aim to determine whether Huperzine A, as compared with placebo, would have an effect on memory function after…
- Trial name
- NCT01676311
- Testing
- Huperzine A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Spaulding Rehabilitation Hospital
Children, Adult, Spastic Cerebral Palsy
Full-spectrum Medical Cannabis for Treatment of Spasticity in Patients With Severe Forms of Cerebral Palsy
The proposed study is a double-blind, placebo-controlled, cross over study on 60 children aged 5 to 25 years with severe spasticity related to cerebral palsy (CP), level IV and V with full-spectrum medical cannabis product of…
- Conditions
- Children, Adult, Spastic Cerebral Palsy, Quality of Life, Cannabis
- Trial name
- HemPhar (NCT04634136)
- Testing
- Lab tests, ECG, Cannabinoid Levels
- Where
- 2 sites in Slovenia
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Atelectasis, Acquired Brain Injury
Variation of Atelectasis Score After High-frequency Percussions in Severe Acquired Brain Injury
Investigators conduced in the Neurological Rehabilitation Unit of the IRCCS "S.Maria Nascente - Fondazione Don Gnocchi", (Milan) a retrospective study on 19 patients hospitalized between September 2018 and February 2021, with the…
- Conditions
- Atelectasis, Acquired Brain Injury, Respiratory Rehabilitation
- Trial name
- NCT05630079
- Testing
- Treatment with Metaneb®, Treatment with IPV®
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Brain Trauma
Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury
The present trial intends to assess whether Salovum®, an egg powder enriched for antisecretory factor given to patients with severe traumatic brain injury will improve outcome compared to a control group given placebo egg powder.
- Trial name
- SASAT (NCT03339505)
- Testing
- Salovum
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Peter Siesjö
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury, Disorders of Consciousness
Alterations in the Brain's Connectome After Severe Traumatic Brain Injury
This study explores the changes in whole-brain connectivity that occur during recovery from severe Traumatic Brain Injury and how these changes are related to the recovery of consciousness.
- Trial name
- ABCinTBI (NCT02424656)
- Testing
- MRI, TMS-EEG, FDG-PET
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Hypertension
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients
Patients with acute brain injury are at risk for complications such as increased pressure in the brain (intracranial pressure (ICP)), decreased blood flow, bleeding, and brain swelling (cerebral edema).
- Trial name
- NCT01526876
- Testing
- clevidipine butyrate
- Sponsor
- Columbia University
Brain Injuries, Traumatic
The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and long term disability, particularly in young adults. Studies from Australia have shown that approximately half of those with severe traumatic brain injury will be…
- Trial name
- POLAR-RCT (NCT00987688)
- Testing
- Hypothermia
- Where
- 15 sites in Australia, France and 4 more
- Volunteers
- 511 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Exocrine Pancreatic Insufficiency, Pancreatitis, Chronic
A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)
The purpose of the study is to evaluate the enzyme activity and safety of pancrelipase in patients with severe Exocrine Pancreatic Insufficiency (EPI)
- Conditions
- Exocrine Pancreatic Insufficiency, Pancreatitis, Chronic, Steatorrhea, Pancreatitis
- Trial name
- NCT00676702
- Testing
- Ensure Plus, Pancrelipase in combination with Ensure Plus
- Volunteers
- 13 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dyskinetic Cerebral Palsy, Dystonic Cerebral Palsy
Cerebellar Deep Brain Stimulation for Movement Disorders in Cerebral Palsy in Children and Young Adults
The purpose of this study is to test the safety of placing Deep Brain Stimulators (DBS) in a part of the brain called the cerebellum and using electrical stimulation of that part of the brain to treat movement symptoms related to…
- Trial name
- NCT06122675
- Testing
- DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Swallowing Disorder, Traumatic Brain Injury
Swallowing Disorders in Minimally Consciousness Patients (MCS)
This study aimed to characterize swallowing disorders in minimally consciousness patients after brain traumatic injury.
- Trial name
- TC-DEG (NCT03562104)
- Testing
- videofluoroscopy, Wessex Head Injury Matrix scale
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Disorders of Consciousness Due to Severe Brain Injury
Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness
Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy.
- Trial name
- Wells-DoC II (NCT07535593)
- Testing
- Transcutaneous electrical stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xijing Hospital
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Brain Injury
Multimodal Neuromonitoring in Acute Brain Injury
Acute brain injury due to aneurysmal subarachnoid haemorrhage (SAH) or traumatic brain injury (TBI) is a condition with a high mortality, and surviving patients often have permanent disabilities.
- Trial name
- NCT06302244
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Palsy
Em-power: Maximizing Functional Independence for Children With Severe Cerebral Palsy
For children with severe cerebral palsy, a powered wheelchair (PWC) may provide their only option for functional mobility and independence.
- Trial name
- NCT06347432
- Testing
- Power wheelchair skills training using the IndieTrainer system
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Grand Valley State University
Aquired Brain Injury
Retrospective Evaluation of Autonomic Activity Through Electrodermal Activity Measurement During Rehabilitation
Severe acquired brain injury (sABI) is a clinical condition characterised by brain damage severe enough to result in coma, with a worst Glasgow Coma Scale (GCS) score of ≤ 8 during the acute phase and a duration of more than 24…
- Trial name
- EDA-sABI (NCT07835659)
- Testing
- EmbracePlus EDA device
- Volunteers
- 72 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Disorders of Consciousness
Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury
Patients with severe brain injuries often have slow accumulating recoveries of function. In ongoing studies, we have discovered that elements of electrical activity during sleep may correlate with the level of behavioral recovery…
- Trial name
- NCT02732288
- Testing
- melatonin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Acquired Brain Injury
Action Observation Theraphy in Severe Acquired Brain Injury.
Action Observation Therapy (AOT) is a rehabilitation technique, used for several years, aimed at the recovery of motor function in patients with neurological and orthopedic conditions.
- Trial name
- NCT05747222
- Testing
- Action Observation Tharapy, Conventional Therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS