Clinical trials: Severe Brain Trauma
Acquired Brain Injury
Exploring the Use of the Cognitive Orientation to Daily Occupational Performance Approach (CO-OP) With Children, Teenagers and Young Adults With Executive Functions Deficits Following Severe Acquired Brain Injury
Acquired brain injury (ABI) in childhood are the cause of disabling motor, cognitive and behavioural disorders, with severe consequences on the later development of autonomy and learning, with long-term repercussions on…
- Trial name
- REFECO-OP (NCT04560777)
- Testing
- CO-OP intervention
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Brain Injuries, Traumatic, Concussion, Mild
Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes
This study is Part 1 of data collection from 18-25 years old subject population for validation of previously derived algorithms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Severe
- Trial name
- CASVAL (NCT02957461)
- Testing
- BrainScope Ahead 200iD
- Where
- 8 sites in United States
- Volunteers
- 420 people
- Sponsor
- BrainScope Company, Inc.
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Brain Injuries, Traumatic
The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and long term disability, particularly in young adults. Studies from Australia have shown that approximately half of those with severe traumatic brain injury will be…
- Trial name
- POLAR-RCT (NCT00987688)
- Testing
- Hypothermia
- Where
- 15 sites in Australia, France and 4 more
- Volunteers
- 511 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Traumatic Brain Injury
Antisecretory Factor In Severe Traumatic Brain Injury
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury.
- Trial name
- AFISTBI (NCT04117672)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Spinal Cord Injuries, Multiple System Atrophy, Parkinson Variant
Transcutaneous Spinal Cord Stimulation Home Study
The goal of this pilot clinical trial is to examine the safety and feasibility of SCONE as home based therapy for orthostatic hypotension and bowel dysfunction in individuals with spinal cord injury or multiple system atrophy.
- Trial name
- NCT06838637
- Testing
- Spinal COrd NEuromodulation ("SCONE") Device
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Michael Berger
Concussion, Mild, Concussion, Brain
Building Emotional Self-Awareness Teletherapy (BEST)
To examine the feasibility, acceptability, and preliminary efficacy of a remotely delivered intervention for civilians and service members with mild traumatic brain injury (mTBI) who have difficulty recognizing and regulating…
- Conditions
- Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate
- Trial name
- BEST (NCT05623046)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Traumatic Brain Injury, Disorders of Consciousness
Alterations in the Brain's Connectome After Severe Traumatic Brain Injury
This study explores the changes in whole-brain connectivity that occur during recovery from severe Traumatic Brain Injury and how these changes are related to the recovery of consciousness.
- Trial name
- ABCinTBI (NCT02424656)
- Testing
- MRI, TMS-EEG, FDG-PET
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Traumatic Brain Injury, Acute Respiratory Failure
Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury
Despite almost universal usage of supplemental oxygen therapy in patients presenting in the emergency department with traumatic brain injury (TBI), optimal oxygen levels are unclear.
- Conditions
- Traumatic Brain Injury, Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Acute Brain Injury
- Trial name
- INACHOS (NCT05464277)
- Testing
- Oxygen
- Where
- 2 sites in Greece
- Volunteers
- 1 people
- Sponsor
- Evangelismos Hospital
Tracheostomy Decannulation, Acquired Brain Injury
Comparison of the Decannulation Protocol With Suctioning and Capping in Severe Acquired Brain Injury Patients
Single-center randomized trail focused on tracheostomized patients with severe acquired brain injury , comparing two different decannulation protocols: 1.
- Trial name
- NCT04835272
- Testing
- the Decannulation Protocol With Suctioning
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Major Depressive Disorder
Characterizing Psychological Consequences of Childhood Trauma
This study will characterize the mental health consequences of early-life trauma.
- Trial name
- NCT00209105
- Testing
- DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Emory University
Brain Injuries
Efficiency of Coupling Targeted Temperature Management to Brain Temperature in Severe Brain Injury
In severe brain-injured patients, it is recommended to strictly control the fever in order to limit brain damage (objective of neuroprotection) via the targeted temperature management (TTM).
- Trial name
- BRAINTTM (NCT03967626)
- Testing
- external cooling with the xxxxx device
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Nervous System Diseases
Cost/Utility Ratio in the Management of Patients With Acquired Severe Brain Injury
The aim of this study was to compare the cost/utility ratio of a management model of integrated, graded, intensive rehabilitation (GIR) versus usual care (UC) for patients with acquired Severe Brain Injury (SBI).
- Trial name
- NCT01743261
- Testing
- multidisciplinary intervention, usual care
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury
Effect of Early Memantine Administration on Outcome of Participents with Moderate to Severe Traumatic Brain Injury
- Trial name
- NCT05531383
- Testing
- Memantine Hydrochloride
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Traumatic Brain Injury
Pupillometry for the Prediction of Neurologic Outcomes in Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is a major cause of morbidity and mortality in the US. The CDC states that 1.7 million people sustain a traumatic brain injury each year, with death occurring in 52,000 of these injured patients.
- Trial name
- NCT02465242
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Our Lady of the Lake Hospital
Traumatic Brain Injury
TBI-Prognosis Multicenter Prospective Study
Severe traumatic brain injury (TBI) is the leading cause of death and disability among people under 45 years of age and a major public health problem.
- Trial name
- NCT02452541
- Testing
- Prognostic tests
- Where
- 17 sites in Canada
- Volunteers
- 315 people
- Sponsor
- CHU de Quebec-Universite Laval
Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke
Evaluation of Consciousness by Brain-computer Interface in Severely Brain Damaged Patients
The objective of this study is to show that the measurement of auditory and vibro-tactile evoked potentials, or the recording of the EEG signal during a motor imaging task, can be used in routine clinical situations to explore…
- Conditions
- Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke, Brain Hypoxia
- Trial name
- AWAKE (NCT03998930)
- Testing
- Clinical evaluation of consciousness by the Coma Recovery Scale Revised (CRS-R)
- Where
- 4 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Brain Injuries
Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Severe Traumatic Brain Injury
"Severe traumatic brain injury (TBI) is a serious condition, common in young adults. It leads to sensorimotor and cognitive sequelae that hinder social reintegration.
- Trial name
- TC-Mouv (NCT05094999)
- Testing
- Proprioceptive stimulations
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury (TBI)
Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury
Due to ethical and logistical challenges related to paediatric research, there is limited age-appropriate evidence for managing paediatric traumatic brain injury (pTBI).
- Trial name
- PROMPT (NCT07538440)
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust